Invitrogen

AGTR1 Polyclonal Antibody

6 Published Figures

10 References

View all (23) AGTR1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (4)
Published Figures (6)

AGTR1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

AGTR1 Antibody (PA5-20812) in ICC/IF

Immunofluorescence of AGTR1 in Mouse Kidney cells with AGTR1 Polyclonal Antibody (Product # PA5-20812) at 20 µg/mL.

AGTR1 Antibody in Immunohistochemistry (IHC)

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Product Details

PA5-20812

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

View 3 publications 3 publications

Immunohistochemistry (IHC)

2.5 µg/mL

View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

5 µg/mL

View 1 publication 1 publication

Flow Cytometry (Flow)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Chicken, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A 16 amino acid peptide from near the center of human AGTR1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11157209

Product Specific Information

A suggested positive control is mouse kidney tissue lysate.

PA5-20812 can be used with blocking peptide PEP-0926.

Target Information

AGTR1 is known as Angiotensin II Type 1 Receptor. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. And it acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. Moreover, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Differential expression of the angiotensin receptors (AT1, AT2, and AT4) in the placental bed of HIV-infected preeclamptic women of African ancestry.

Hypertension research : official journal of the Japanese Society of Hypertension

Singh S,Moodley J,Naicker T

PA5-20812 was used in Immunohistochemistry to demonstrate a significant downregulation of AT2R and AT4R with a concomitant elevated AT1R immunoexpression within PB of HIV-infected PE women.

Tue Aug 01 00:00:00 EDT 2023

Angiotensin II enhances group 2 innate lymphoid cell responses via AT1a during airway inflammation.

The Journal of experimental medicine

Liu G,Chen Y,Wang Y,Deng X,Xiao Q,Zhang L,Xu H,Han X,Lei A,He J,Li X,Cao Y,Zhou P,He C,Wu P,Jiang W,Tan M,Chen C,Yang Q,Lu L,Deng K,Yao Z,Zhou J

PA5-20812 was used in Immunohistochemistry-immunofluorescence to identify angiotensin (Ang) II as a positive regulator of ILC2s and its levels being associated with disease severity in asthmatic patients.

Mon Mar 07 00:00:00 EST 2022

In Vitro Characterization of a Tissue Renin-Angiotensin System in Human Nucleus Pulposus Cells.

Cells

Saravi B,Li Z,Basoli V,Grad S,Häckel S,Albers CE,Alini M,Schmal H,Obid P,Lang G

PA5-20812 was used in Immunohistochemistry-immunofluorescence to indicate that tRAS modulation might be a novel therapeutic approach to intervertebral disc disease.

Fri Oct 28 00:00:00 EDT 2022

Myogenic Vasoconstriction Requires Canonical G_q/11 Signaling of the Angiotensin II Type 1 Receptor.

Journal of the American Heart Association

Cui Y,Kassmann M,Nickel S,Zhang C,Alenina N,Anistan YM,Schleifenbaum J,Bader M,Welsh DG,Huang Y,Gollasch M

PA5-20812 was used in Flow cytometry/Cell sorting to demonstrate that myogenic arterial constriction requires Gq/11-dependent signaling pathways of mechanoactivated AT1R but not G protein-independent, noncanonical pathways in smooth muscle cells.

Tue Feb 15 00:00:00 EST 2022

Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells.

Frontiers in pharmacology

Okoloko O,Vanderwall ER,Rich LM,White MP,Reeves SR,Harrington WE,Barrow KA,Debley JS

Published figure using AGTR1 polyclonal antibody (Product # PA5-20812) in Immunocytochemistry

Thu Nov 23 00:00:00 EST 2023

Spent Hen Muscle Protein-Derived RAS Regulating Peptides Show Antioxidant Activity in Vascular Cells.

Antioxidants (Basel, Switzerland)

Fan H,Bhullar KS,Wu J

PA5-20812 was used in Western Blotting to reveal that all four peptides attenuated oxidative stress in both cells.

Mon Feb 15 00:00:00 EST 2021

Spent Hen Muscle Protein-Derived RAS Regulating Peptides Show Antioxidant Activity in Vascular Cells.

Antioxidants (Basel, Switzerland)

Fan H,Bhullar KS,Wu J

PA5-20812 was used in Western Blotting to reveal that all four peptides attenuated oxidative stress in both cells.

Mon Feb 15 00:00:00 EST 2021

Effect of (-)-epicatechin on the modulation of progression markers of chronic renal damage in a 5/6 nephrectomy experimental model.

Heliyon

Montes-Rivera J,Arellano-Mendoza M,Nájera N,Del Valle-Mondragón L,Villarreal F,Rubio-Gayosso I,Perez-Duran J,Meaney E,Ceballos G

PA5-20812 was used in Western Blotting to indicate that (-)-epicatechin is able to decrease the progression of chronic kidney disease.

Mon Apr 01 00:00:00 EDT 2019

Data supporting that adipose-derived mesenchymal stem/stromal cells express angiotensin II receptors in situ and in vitro.

Data in brief

Ageeva LV,Sysoeva VY,Tyurin-Kuzmin PA,Sharonov GV,Dyikanov DT,Stambolsky DV,Kalinina NI

Published figure using AGTR1 polyclonal antibody (Product # PA5-20812) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Data supporting that adipose-derived mesenchymal stem/stromal cells express angiotensin II receptors in situ and in vitro.

Data in brief

Ageeva LV,Sysoeva VY,Tyurin-Kuzmin PA,Sharonov GV,Dyikanov DT,Stambolsky DV,Kalinina NI

Published figure using AGTR1 polyclonal antibody (Product # PA5-20812) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Differential expression and DNA methylation of angiotensin type 1A receptors in vascular tissues during genetic hypertension development.

Molecular and cellular biochemistry

Pei F,Wang X,Yue R,Chen C,Huang J,Huang J,Li X,Zeng C

PA5-20812 was used in western blot to study AT1aR expression and methylation during the development of hypertension

Wed Apr 01 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: angiotensin II receptor, type 1; Angiotensin II type-1 receptor; Angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1; angiotensin receptor 1a; AT1 receptor; AT1 receptor A; AT1AR; AT1BR; Type-1 angiotensin II receptor; Type-1 angiotensin II receptor A; type-1A angiotensin II receptor; type-1B angiotensin II receptor; vascular type-1 angiotensin II receptor

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Gene Aliases: 1810074K20Rik; AG2S; Agtr-1a; AGTR1; AGTR1A; AGTR1B; AI551199; Angtr-1a; AT1; AT1A; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R

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UniProt ID: (Human) P30556, (Rat) P25095, (Mouse) P29754

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Entrez Gene ID: (Human) 185, (Rat) 24180, (Mouse) 11607

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Function(s)

angiotensin type I receptor activity angiotensin type II receptor activity protein binding bradykinin receptor binding protein heterodimerization activity G-protein alpha-subunit binding peptide hormone binding protein kinase binding D1 dopamine receptor binding protein self-association signal transducer activity G-protein coupled receptor activity G-protein coupled receptor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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AGTR1 Polyclonal Antibody

AGTR1 Antibody (PA5-20812) in ICC/IF

Product Details

PA5-20812

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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