Invitrogen

AGTR1 Monoclonal Antibody (11B3)

View all (23) AGTR1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-42535

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:50-1:100
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

11B3

Immunogen

Synthetic peptide within human Angiotensin II Type 1 Receptor aa 300-350
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Purification

Protein G

Storage buffer

TBS, pH 7.4, with 50% glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2911676

Product Specific Information

Positive Control: PC-12 cell lysate, A549 cell lysate, HepG2 cell lysate, Hela cell lysate, PC-12, 293T, A549.

Subcellular Location: Cell membrane, Membrane.

Target Information

AGTR1 is known as Angiotensin II Type 1 Receptor. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. And it acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. Moreover, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: angiotensin II receptor, type 1; Angiotensin II type-1 receptor; Angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1; angiotensin receptor 1a; AT1 receptor; AT1 receptor A; AT1AR; AT1BR; Type-1 angiotensin II receptor; Type-1 angiotensin II receptor A; type-1A angiotensin II receptor; type-1B angiotensin II receptor; vascular type-1 angiotensin II receptor

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Gene Aliases: 1810074K20Rik; AG2S; Agtr-1a; AGTR1; AGTR1A; AGTR1B; AI551199; Angtr-1a; AT1; AT1A; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R

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UniProt ID: (Human) P30556, (Rat) P25095, (Mouse) P29754

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Entrez Gene ID: (Human) 185, (Rat) 24180, (Mouse) 11607

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Function(s)
angiotensin type I receptor activity angiotensin type II receptor activity protein binding bradykinin receptor binding protein heterodimerization activity G-protein alpha-subunit binding peptide hormone binding protein kinase binding D1 dopamine receptor binding protein self-association signal transducer activity G-protein coupled receptor activity G-protein coupled receptor
Process(es)
regulation of cell growth kidney development renin-angiotensin regulation of aldosterone production regulation of blood vessel size by renin-angiotensin regulation of systemic arterial blood pressure by renin-angiotensin G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration Rho protein signal transduction positive regulation of macrophage derived foam cell differentiation positive regulation of cholesterol esterification regulation of vasoconstriction calcium-mediated signaling positive regulation of cellular protein metabolic process positive regulation of phospholipase A2 activity positive regulation of NAD(P)H oxidase activity low-density lipoprotein particle remodeling regulation of renal sodium excretion angiotensin-activated signaling pathway regulation of cell proliferation regulation of vasodilation regulation of inflammatory response positive regulation of inflammatory response positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway cell chemotaxis phospholipase C-activating angiotensin-activated signaling pathway positive regulation of reactive oxygen species metabolic process blood vessel development positive regulation of receptor recycling regulation of systemic arterial blood pressure by circulatory renin-angiotensin renin secretion into blood stream regulation of renal output by angiotensin brain renin-angiotensin system regulation of pH inflammatory response heart development aging regulation of blood pressure positive regulation of cell proliferation positive regulation of superoxide anion generation regulation of smooth muscle cell apoptotic process negative regulation of smooth muscle cell apoptotic process vasoconstriction dopamine biosynthetic process drinking behavior activation of Janus kinase activity negative regulation of neuron apoptotic process response to estrogen positive regulation of blood pressure positive regulation of cytokine secretion cellular response to dexamethasone stimulus positive regulation of branching involved in ureteric bud morphogenesis signal transduction
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