Proteintech

AIF Polyclonal Antibody

AIF Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 15

AIF Antibody (17984-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using AIF antibody (Product # 17984-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-phalloidin (red).

AIF Antibody in Immunohistochemistry (Paraffin) (IHC (P))

AIF Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17984-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:8,000

View 55 publications 55 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

1:10-1:100

View 9 publications 9 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat, Sheep

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

AIF Fusion Protein Ag12400 (259-609 aa encoded by BC111065)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TPRSLSAID RAGAEVKSRT TLFRKIGDFR SLEKISREVK SITIIGGGFL GSELACALGR KARALGTEVI QLFPEKGNMG KILPEYLSNW TMEKVRREGV KVMPNAIVQS VGVSSGKLLI KLKDGRKVET DHIVAAVGLE PNVELAKTGG LEIDSDFGGF RVNAELQARS NIWVAGDAAC FYDIKLGRRR VEHHDHAVVS GRLAGENMTG AAKPYWHQSM FWSDLGPDVG YEAIGLVDSS LPTVGVFAKA TAQDNPKSAT EQSGTGIRSE SETESEASEI TIPPSTPAVP QAPVQGEDYG KGVIFYLRDK VVVGIVLWNI FNRMPIARKI IKDGEQHEDL NEVAKLFNIH ED (259-609 aa encoded by BC111065)

Target Information

Apoptosis Inducing Factor (AIF) causes chromatin condensation and DNA fragmentation. AIF was recently identified, and cloned. Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection and apoptosis stimuli. AIF is highly conserved between human and mouse and widely expressed. Mutations in the AIF gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants of AIF and a related pseudogene has been identified on chromosome 10.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Experimental and therapeutic medicine

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Experimental and therapeutic medicine

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Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549.

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Fri Jul 25 00:00:00 EDT 2014

Proteomic analysis of mitochondria from infantile hemangioma endothelial cells treated with sodium morrhuate and its liposomal formulation.

Journal of biochemical and molecular toxicology

Tu JB,Dong Q,Hu XY,Jiang F,Ma RZ,He LY,Yang ZQ

Sat Sep 01 00:00:00 EDT 2012

Proteomic analysis of mitochondria from infantile hemangioma endothelial cells treated with sodium morrhuate and its liposomal formulation.

Journal of biochemical and molecular toxicology

Tu JB,Dong Q,Hu XY,Jiang F,Ma RZ,He LY,Yang ZQ

Sat Sep 01 00:00:00 EDT 2012

Characterization of 9-nitrocamptothecin liposomes: anticancer properties and mechanisms on hepatocellular carcinoma in vitro and in vivo.

PloS one

Zheng S,Chang S,Lu J,Chen Z,Xie L,Nie Y,He B,Zou S,Gu Z

Fri Oct 21 00:00:00 EDT 2011

Characterization of 9-nitrocamptothecin liposomes: anticancer properties and mechanisms on hepatocellular carcinoma in vitro and in vivo.

PloS one

Zheng S,Chang S,Lu J,Chen Z,Xie L,Nie Y,He B,Zou S,Gu Z

Fri Oct 21 00:00:00 EDT 2011

Bioinformatics

Protein Aliases: AGR1; Apoptosis-inducing factor 1, mitochondrial; apoptosis-inducing factor, mitochondrion-associated, 1; ERP18; ERP19; hAG-1; harlequin; MGC111425; pcd8; PDIA16; programmed cell death 8 (apoptosis-inducing factor); Programmed cell death protein 8; RP3-438D16.2; striatal apoptosis-inducing factor; testicular secretory protein Li 4; TLP19; UNQ713/PRO1376

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Gene Aliases: AIF; AIFM1; AIFsh2; CMT2D; CMTX4; COWCK; COXPD6; DFNX5; Hq; NADMR; NAMSD; PDCD8

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UniProt ID: (Human) O95831, (Mouse) Q9Z0X1, (Rat) Q9JM53

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Entrez Gene ID: (Human) 9131, (Mouse) 26926, (Rat) 83533

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Function(s)

Process(es)

response to ischemia DNA catabolic process apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process response to toxic substance chromosome condensation positive regulation of apoptotic process positive regulation of neuron apoptotic process cell redox homeostasis neuron apoptotic process oxidation-reduction process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to hydrogen peroxide cellular response to estradiol stimulus cellular response to nitric oxide cellular response to oxygen-glucose deprivation response to L-glutamate regulation of apoptotic DNA fragmentation cellular response to aldosterone response to oxidative stress apoptotic mitochondrial changes positive regulation of cell death neuron differentiation mitochondrial respiratory chain complex I assembly

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AIF Polyclonal Antibody

AIF Antibody (17984-1-AP) in ICC/IF

Product Details

17984-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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