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FIGURE: 1 / 3
AIM2 Antibody (HA500270) in ICC/IF
ICC staining of AIM2 in A431 cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 10% negative goat serum for 15 minutes at room temperature. Cells were probed with the primary antibody (HA500270, 1:50) for 1 hour at room temperature, washed with PBS. Alexa Fluor®488 conjugate-Goat anti-Rabbit IgG was used as the secondary antibody at 1:1,000 dilution. The nuclear counter stain is DAPI (blue).
Product Details
HA500270
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within human AIM2 aa 50-150/343.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Target Information
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Absent in melanoma 2; Interferon-inducible protein AIM2; RP11-520H16.3
Gene Aliases: AIM2; PYHIN4
UniProt ID: (Human) O14862
Entrez Gene ID: (Human) 9447
activation of innate immune response
positive regulation of defense response to virus by host
apoptotic process
inflammatory response
immune response
negative regulation of NF-kappaB transcription factor activity
positive regulation of protein oligomerization
positive regulation of interleukin-1 beta production
tumor necrosis factor-mediated signaling pathway
cellular response to interferon-beta
cellular response to drug
innate immune response
interleukin-1 beta secretion
positive regulation of interleukin-1 beta secretion
positive regulation of NF-kappaB transcription factor activity
pyroptosis
positive regulation of cysteine-type endopeptidase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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