Product References
Muscle fibre transition and transcriptional changes of horse skeletal muscles during traditional Mongolian endurance training.
Equine veterinary journal
Bou T,Ding W,Ren X,Liu H,Gong W,Jia Z,Zhang X,Dugarjaviin M,Bai D
Mon Jan 01 00:00:00 EST 2024
WITHDRAWN: Expression of Tmem41b and MMP13 associated with poor outcome in osteosarcomas.
Neoplasma
Li GH,Liu X,Feng LJ,Zhang L
Sun Aug 20 00:00:00 EDT 2023
Promotion of the genipin crosslinked chitosan-fiber hydrogel loaded with sustained release of clemastine fumarate in diabetic wound repair.
International journal of biological macromolecules
Zuo R,Shi J,Jiang S,Chu M,Wang Q,Kong L,Kang Q,Guo Y,Guan J
Tue Jan 31 00:00:00 EST 2023
Visceral adipose tissue-directed human kallistatin gene therapy improves adipose tissue remodeling and metabolic health in obese mice.
Cellular signalling
Wu Y,Jiang Y,Guo JQ,Yang ZW,Carvalho A,Qian LL,Ji JJ,Ji ZJ,Ma GS,Yao YY
Thu Jun 01 00:00:00 EDT 2023
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function.
Acta pharmacologica Sinica
Zhou XH,Cheng ZP,Lu M,Lin WY,Luo LL,Ming ZY,Hu Y
Wed Feb 01 00:00:00 EST 2023
Identification of a novel small-molecule inhibitor of miR-29b attenuates muscle atrophy.
Molecular therapy. Nucleic acids
Liu Q,Yuan W,Yan Y,Jin B,You M,Liu T,Gao M,Li J,Gokulnath P,Vulugundam G,Li G,Xu B,Xiao J
Tue Mar 14 00:00:00 EDT 2023
Silk Fibroin and Sericin Differentially Potentiate the Paracrine and Regenerative Functions of Stem Cells Through Multiomics Analysis.
Advanced materials (Deerfield Beach, Fla.)
Zhang Y,Sheng R,Chen J,Wang H,Zhu Y,Cao Z,Zhao X,Wang Z,Liu C,Chen Z,Zhang P,Kuang B,Zheng H,Shen C,Yao Q,Zhang W
Mon May 01 00:00:00 EDT 2023
Biochemical and clinical effects of RPS20 expression in renal clear cell carcinoma.
Oncology reports
Shen C,Chen Z,Zhang Y,Xu W,Peng R,Jiang J,Zuo W,Fan Y,Zheng B
Sun Jan 01 00:00:00 EST 2023
ARID1B blocks methionine-stimulated mTOR activation to inhibit milk fat and protein synthesis in and proliferation of mouse mammary epithelial cells.
The Journal of nutritional biochemistry
Lin G,Qi H,Guo X,Wang W,Zhang M,Gao X
Sat Apr 01 00:00:00 EDT 2023
Glioblastoma upregulates SUMOylation of hnRNP A2/B1 to eliminate the tumor suppressor miR-204-3p, accelerating angiogenesis under hypoxia.
Cell death & disease
Guo Q,Fan Y,Wang Q,Li B,Qiu W,Qi Y,Pan Z,Zhang S,Zhao S,Yang K,Xu H,Li M,Gao Z,Xu J,Wang H,Wang S,Tang Q,Qiu J,Guo X,Deng L,Zhang P,Zhao R,Xue H,Wang C,Li G
Tue Feb 21 00:00:00 EST 2023
ARID3A plays a key regulatory role in palmitic acid-stimulated milk fat synthesis in mouse mammary epithelial cells.
Cell biology international
Guo X,Qi H,Lin G,Yu J,Zhang M,Gao X
Thu Jun 01 00:00:00 EDT 2023
ATAXIA TELANGIECTASIA MUTATED PROTECTS AGAINST LIPOPOLYSACCARIDE-INDUCED BLOOD-BRAIN BARRIER DISRUPTION BY REGULATING ATK/DRP1-MEDIATED MITOCHONDRIAL HOMEOSTASIS.
Shock (Augusta, Ga.)
Luo S,Lyu Z,Ge L,Li Y,Liu Y,Yuan Y,Zhao R,Huang L,Zhao J,Huang H,Luo Y
Sat Jul 01 00:00:00 EDT 2023
Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.
Physiological research
Ma Y,Du Y,Yang J,He Q,Wang H,Lin X
Sun Apr 30 00:00:00 EDT 2023
Heterodimerization of cholecystokinin 1 and cholecystokinin 2 receptors in gallbladder cancer: a new mechanism for carcinogenesis.
Journal of cancer research and clinical oncology
Nigam J,Kazmi HR,Khare L,Srivastava M,Chandra A
Tue Aug 01 00:00:00 EDT 2023
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
Translational oncology
Deng Y,Ma J,Zhao S,Yang M,Sun Y,Zhang Q
Wed Feb 01 00:00:00 EST 2023
Targeting complement C5a to improve radiotherapy sensitivity in non-small cell lung cancer.
Translational lung cancer research
Yuan M,Wang C,Wu Y,Qiao L,Deng G,Liang N,Chen F,Liu L,Chen Y,Yang Y,Wang H,Liu T,Yang X,Zhang Y,Lv Y,Suwinski R,Hu P,Zhang Y,Zhang J
Wed May 31 00:00:00 EDT 2023
Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of Schisandra Chinensis Mixture on diabetic nephropathy.
Journal of ethnopharmacology
Ma Y,Deng Y,Li N,Dong A,Li H,Chen S,Zhang S,Zhang M
Fri Feb 10 00:00:00 EST 2023
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Journal of orthopaedic translation
Lu R,Xu H,Deng X,Wang Y,He Z,Xu S,Liang S,Huang X,You H,Guo F,Cheng P,Chen AM
Wed Mar 01 00:00:00 EST 2023
GIPC2 is a tumor suppressor gene for acute myeloid leukemia and induces apoptosis of leukemia cells by regulating the PI3K/AKT pathway.
Epigenomics
Zhao J,Liu J,Liu S,Tian S,Yuan H,Li S
Wed Mar 01 00:00:00 EST 2023
Upregulation of LRRC8A by m5C modification-mediated mRNA stability suppresses apoptosis and facilitates tumorigenesis in cervical cancer.
International journal of biological sciences
Chen Y,Zuo X,Wei Q,Xu J,Liu X,Liu S,Wang H,Luo Q,Wang Y,Yang Y,Zhao H,Xu J,Liu T,Yi P
Thu Feb 09 00:00:00 EST 2023
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Transplantation and cellular therapy
Wang X,Zhou Y,Sun Q,Zhang Q,Zhou H,Zhang J,Du Y,Wang Y,Yuan K,Xu L,Zhang M,Yan D,Zeng L,Xu K,Sang W
Tue Aug 01 00:00:00 EDT 2023
Targeting L-Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhao Y,Zhang J,Cheng X,Huang W,Shen S,Wu S,Huang Y,Nie G,Wang H,Qiu W
Sat Jul 01 00:00:00 EDT 2023
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Experimental biology and medicine (Maywood, N.J.)
Wang W,Gu Y,Ni H,Quan Q,Guo L
Thu Jun 01 00:00:00 EDT 2023
Differences in p38-STAT3-S100A11 signaling after the administration of aristolochic acid I and IVa may account for the disparity in their nephrotoxicity.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Xian Z,Tian J,Zhao Y,Yi Y,Li C,Han J,Zhang Y,Wang Y,Wang L,Liu S,Pan C,Liu C,Wang D,Meng J,Tang X,Wang F,Liang A
Thu Jun 01 00:00:00 EDT 2023
The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy.
Acta biochimica et biophysica Sinica
Wu J,Xiao D,Yu K,Shalamu K,He B,Zhang M
Sat Feb 25 00:00:00 EST 2023
HDAC inhibitor chidamide overcomes drug resistance in chronic myeloid leukemia with the T315i mutation through the Akt-autophagy pathway.
Human cell
Yin L,Zhang Q,Xie S,Cheng Z,Li R,Zhu H,Yu Q,Yuan H,Wang C,Peng H,Zhang G
Sat Jul 01 00:00:00 EDT 2023
Xiaoyaosan ameliorates depressive-like behavior and susceptibility to glucose intolerance in rat: involvement of LepR-STAT3/PI3K pathway in hypothalamic arcuate nucleus.
BMC complementary medicine and therapies
Qiu W,Wu Q,Zhang K,Da X,Tang K,Yuan N,Deng L,Wu M,Zhang Y,Quan J,Ma Q,Li X,Chen J
Wed Apr 12 00:00:00 EDT 2023
CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway.
Leukemia research
Deng X,Zeng Y,Qiu X,Zhong M,Xiong X,Luo M,Zhang J,Chen X
Sat Jul 01 00:00:00 EDT 2023
Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis.
Cell death discovery
Li D,Xia L,Huang P,Wang Z,Guo Q,Huang C,Leng W,Qin S
Sat Jan 21 00:00:00 EST 2023
A peptide encoded by lncRNA MIR7-3 host gene (MIR7-3HG) alleviates dexamethasone-induced dysfunction in pancreatic β-cells through the PI3K/AKT signaling pathway.
Biochemical and biophysical research communications
Mao X,Zhou J,Kong L,Zhu L,Yang D,Zhang Z
Sun Mar 05 00:00:00 EST 2023
Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation.
iScience
Zhang C,Liu Z,Wang X,Zhang B,Cui L,Hu Q,Hu B,Cao K,Shan W,Shi H,Wang R
Fri Jun 16 00:00:00 EDT 2023
Bone marrow mesenchymal stem cells repair hexavalent chromium-induced testicular injury by regulating autophagy and ferroptosis mediated by the AKT/mTOR pathway in rats.
Environmental toxicology
Zhuge R,Li Z,He C,Ma W,Yan J,Xue Q,Wang R,Liu Y,Lu R,Du H,Yin F,Guo L
Wed Feb 01 00:00:00 EST 2023
Bone marrow mesenchymal stem cells repair hexavalent chromium-induced testicular injury by regulating autophagy and ferroptosis mediated by the AKT/mTOR pathway in rats.
Environmental toxicology
Zhuge R,Li Z,He C,Ma W,Yan J,Xue Q,Wang R,Liu Y,Lu R,Du H,Yin F,Guo L
Wed Feb 01 00:00:00 EST 2023
Integrated network pharmacology and experimental verification to explore the molecular mechanism of Jingxin Zhidong formula for treating Tic disorder.
Journal of ethnopharmacology
Tian X,Ou G,Hu S,Wang C,Han F,Gao L
Thu Apr 06 00:00:00 EDT 2023
LMNB1 deletion in ovarian cancer inhibits the proliferation and metastasis of tumor cells through PI3K/Akt pathway.
Experimental cell research
Dong J,Ru Y,Zhai L,Gao Y,Guo X,Chen B,Lv X
Mon May 15 00:00:00 EDT 2023
Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Ai S,Li D,Gu X,Xu Y,Wang Y,Wang HL,Chen XT
Tue Aug 01 00:00:00 EDT 2023
Effect of transmembrane protein 100 on prostate cancer progression by regulating SCNN1D through the FAK/PI3K/AKT pathway.
Translational oncology
Ye Z,Xia Y,Li L,Li B,Chen W,Han S,Zhou X,Chen L,Yu W,Ruan Y,Cheng F
Sun Jan 01 00:00:00 EST 2023
Saxagliptin alleviates erectile dysfunction through increasing stromal cell-derived factor-1 in diabetes mellitus.
Andrology
Sun T,Xu W,Wang J,Wang T,Wang S,Liu K,Liu J
Wed Feb 01 00:00:00 EST 2023
Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis.
Cell & bioscience
Li D,Xia L,Huang P,Wang Z,Guo Q,Huang C,Leng W,Qin S
Mon Jul 03 00:00:00 EDT 2023
Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.
Journal of neuroinflammation
He D,Fu S,Ye B,Wang H,He Y,Li Z,Li J,Gao X,Liu D
Wed Mar 29 00:00:00 EDT 2023
The total alkaloids of Sophora alopecuroides L. improve depression-like behavior in mice via BDNF-mediated AKT/mTOR signaling pathway.
Journal of ethnopharmacology
Li J,Zhang M,Pei Y,Yang Q,Zheng L,Wang G,Sun Y,Yang W,Liu L
Wed Nov 15 00:00:00 EST 2023
Study on the mechanism of aging-related erectile dysfunction based on bioinformatics and experimental verification.
Translational andrology and urology
Sun T,Liu Y,Chen Y,Xu W,Wang T,Liu K,Liu J
Tue Feb 28 00:00:00 EST 2023
Kaempferol promotes melanogenesis and reduces oxidative stress in PIG1 normal human skin melanocytes.
Journal of cellular and molecular medicine
Xie Y,Mei X,Shi W
Sat Apr 01 00:00:00 EDT 2023
Polystyrene microplastics mediate inflammatory responses in the chicken thymus by Nrf2/NF-κB pathway and trigger autophagy and apoptosis.
Environmental toxicology and pharmacology
Li J,Yin K,Hou L,Zhang Y,Lu H,Ma C,Xing M
Thu Jun 01 00:00:00 EDT 2023
Enterococcus faecalis promotes the progression of colorectal cancer via its metabolite: biliverdin.
Journal of translational medicine
Zhang L,Liu J,Deng M,Chen X,Jiang L,Zhang J,Tao L,Yu W,Qiu Y
Thu Feb 02 00:00:00 EST 2023
Berbamine dihydrochloride suppresses the progression of colorectal cancer via RTKs/Akt axis.
Journal of ethnopharmacology
Liu L,Liang D,Zheng Q,Zhao M,Lv R,Tang J,Chen N
Wed Mar 01 00:00:00 EST 2023
Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway.
Journal of ethnopharmacology
Shi Y,Zhang ZW,Du MM,Wu J,Li JX
Thu Aug 10 00:00:00 EDT 2023
Sevoflurane Preconditioning Alleviates Posttraumatic Stress Disorder-Induced Apoptosis in the Hippocampus via the EZH2-Regulated Akt/mTOR Axis and Improves Synaptic Plasticity.
Journal of molecular neuroscience : MN
Gu T,Xu C,Meng X,Gao D,Jiang G,Yin A,Liu Q,Zhang L
Mon May 01 00:00:00 EDT 2023
miR-181b promotes angiogenesis and neurological function recovery after ischemic stroke.
Neural regeneration research
Xue LX,Shu LY,Wang HM,Lu KL,Huang LG,Xiang JY,Geng Z,Zhao YW,Chen H
Fri Sep 01 00:00:00 EDT 2023
Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma.
Cell death & disease
Cai J,Ye Z,Hu Y,Ye L,Gao L,Wang Y,Sun Q,Tong S,Zhang S,Wu L,Yang J,Chen Q
Sat Mar 25 00:00:00 EDT 2023
Pi-Pa-Run-Fei-Tang alleviates lung injury by modulating IL-6/JAK2/STAT3/IL-17 and PI3K/AKT/NF-κB signaling pathway and balancing Th17 and Treg in murine model of OVA-induced asthma.
Journal of ethnopharmacology
Jie XL,Luo ZR,Yu J,Tong ZR,Li QQ,Wu JH,Tao Y,Feng PS,Lan JP,Wang P
Tue Dec 05 00:00:00 EST 2023
Annexin A2 promotes angiogenesis after ischemic stroke via annexin A2 receptor - AKT/ERK pathways.
Neuroscience letters
Lin H,Li W,Shen Z,Bei Y,Wei T,Yu Z,Dai Y,Dai H
Sun Jan 01 00:00:00 EST 2023
PLCB1 Enhances Cell Migration and Invasion in Gastric Cancer Via Regulating Actin Cytoskeletal Remodeling and Epithelial-Mesenchymal Transition.
Biochemical genetics
Wang Y,Tu Z,Zhao W,Wang L,Jiang J,Gu L,Li M,Jiang L,Wang Y,Bi Y
Fri Dec 01 00:00:00 EST 2023
Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression.
Acta pharmacologica Sinica
He XY,Zhu MM,Zheng J,Wang CY,Zhao XK,Zhang BT,Zhou DC,Zhang S,Yang XX,Duan YJ,Han JH,Chen YL
Wed Mar 01 00:00:00 EST 2023
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
Journal of ethnopharmacology
Zhang PP,Zhuo BY,Duan ZW,Li X,Huang SL,Cao Q,Zhao T,Wei SL,Hu XH,Zhang Y
Thu Aug 10 00:00:00 EDT 2023
BI-D1870 Induces Mitotic Dysfunction and Apoptosis in Neuroblastoma by Regulating the PI3K-Akt-mTORC1 Signal Axis.
Cancers
Jin L,Mi T,Wu X,Wang Z,Zhang Z,Liu J,Wang Z,Wang J,Li M,Ren C,Guo P,He D
Tue Mar 28 00:00:00 EDT 2023
A systematic pharmacology-based in vivo study to reveal the effective mechanism of Yupingfeng in asthma treatment.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Liu X,Yu Y,Wu Y,Luo A,Yang M,Li T,Li T,Mao B,Chen X,Fu J,Jiang H,Liu W
Thu Jun 01 00:00:00 EDT 2023
AFP deletion leads to anti-tumorigenic but pro-metastatic roles in liver cancers with concomitant CTNNB1 mutations.
Cancer letters
Xu Y,Zhang X,Zhang R,Sun Y,Liu J,Luo C,Yang J,Fang W,Guo Q,Wei L
Mon Jul 10 00:00:00 EDT 2023
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
Journal of medicinal chemistry
Wang Z,Tan M,Su W,Huang W,Zhang J,Jia F,Cao G,Liu X,Song H,Ran H,Nie G,Wang H
Thu May 11 00:00:00 EDT 2023
Exploration the role of INHBA in Hu sheep granulosa cells using RNA-Seq.
Theriogenology
Bao Y,Li X,El-Samahy MA,Yang H,Wang Z,Yang F,Yao X,Wang F
Wed Feb 01 00:00:00 EST 2023
Aspirin increases the efficacy of gemcitabine in pancreatic cancer by modulating the PI3K/AKT/mTOR signaling pathway and reversing epithelial‑mesenchymal transition.
Oncology letters
Zhou H,Yun X,Shu Y,Xu K
Wed Mar 01 00:00:00 EST 2023
microRNA-17 is a tumor suppressor in oral squamous cell carcinoma and is repressed by LSD1.
Oral diseases
Wangzhou K,Fu W,Li M,Lu Z,Lai Z,Liu C,Tan Y,Hao C
Wed Mar 01 00:00:00 EST 2023
Protective role of cezanne in doxorubicin-induced cardiotoxicity by inhibiting autophagy, apoptosis and oxidative stress.
Toxicology
Zhang J,Zha Y,Jiao Y,Li Y,Zhang S
Wed Feb 01 00:00:00 EST 2023
ANRIL promotes the regulation of colorectal cancer on lymphatic endothelial cells via VEGF-C and is the key target for Pien Tze Huang to inhibit cancer metastasis.
Cancer gene therapy
Huang B,Lu Y,Ni Z,Liu J,He Y,An H,Ye F,Shen J,Lin M,Chen Y,Lin J
Fri Sep 01 00:00:00 EDT 2023
Mechanism of Xiezhuo Huayu Yiqi Tongluo Formula in the Treatment of Uric Acid Nephropathy Based on Network Pharmacology, Molecular Docking, and In Vivo Experiments.
Evidence-based complementary and alternative medicine : eCAM
Fan L,Guo Y,Wu Q,Hu T,Chen X,Guo J,Liu Y,Lu Y,Lin M
Sat Mar 04 00:00:00 EST 2023
Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.
Chinese journal of integrative medicine
Ge XF,Li SS,Liu YH,Lu MQ,Su HN,Yang X,Sun XW
Thu Jun 01 00:00:00 EDT 2023
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
iScience
Lu R,Wei Z,Wang Z,Xu S,Sun K,Cheng P,Huang X,You H,Guo F,Liang S,Chen AM
Fri Feb 17 00:00:00 EST 2023
The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region.
Cell reports
Fan G,Wang F,Chen Y,Zheng Q,Xiong J,Lv Q,Wu K,Xiong J,Wei L,Li D,Zhang J,Zhang W,Li F
Tue Jan 31 00:00:00 EST 2023
The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region.
Cell reports
Fan G,Wang F,Chen Y,Zheng Q,Xiong J,Lv Q,Wu K,Xiong J,Wei L,Li D,Zhang J,Zhang W,Li F
Tue Jan 31 00:00:00 EST 2023
The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region.
Cell reports
Fan G,Wang F,Chen Y,Zheng Q,Xiong J,Lv Q,Wu K,Xiong J,Wei L,Li D,Zhang J,Zhang W,Li F
Tue Jan 31 00:00:00 EST 2023
Aerobic exercise ameliorates insulin resistance in C57BL/6 J mice via activating Sestrin3.
Biochimica et biophysica acta. Molecular basis of disease
Han X,Yang Y,Liu S,Niu Y,Shao H,Fu L
Sun Jan 01 00:00:00 EST 2023
Deciphering the underlying wound healing mechanisms of Streptocaulon juventas (Lour.) Merr. by integrating network pharmacology, transcriptomics, and experimental validation.
Journal of ethnopharmacology
Li Y,Zang J,Wang X,Feng X,Qiu F
Fri Feb 10 00:00:00 EST 2023
Deletion of the tyrosine phosphatase Shp2 in cervical cancer cells promotes reprogramming of glutamine metabolism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Gao X,Kang J,Li X,Chen C,Luo D
Sat Apr 01 00:00:00 EDT 2023
Brevilin A Inhibits VEGF-Induced Angiogenesis through ROS-Dependent Mitochondrial Dysfunction.
Oxidative medicine and cellular longevity
Wei B,Hao Z,Zheng H,Qin Y,Zhao F,Shi L
Tue Jan 10 00:00:00 EST 2023
Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H2O2-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway.
Antioxidants (Basel, Switzerland)
Xiong L,Wu H,Zhong T,Luo F,Li Q,Li M,Fan Y
Wed Oct 12 00:00:00 EDT 2022
Chronic vitamin D3 supplementation alleviates cognition impairment via inhibition of oxidative stress regulated by PI3K/AKT/Nrf2 in APP/PS1 transgenic mice.
Neuroscience letters
Lin J,Niu Z,Xue Y,Gao J,Zhang M,Li M,Peng Y,Zhang S,Li W,Zhang Q,Li X
Wed Jul 13 00:00:00 EDT 2022
Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Hao M,Ding C,Peng X,Chen H,Dong L,Zhang Y,Chen X,Liu W,Luo Y
Sat Oct 01 00:00:00 EDT 2022
N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.
Cell death & disease
Wang R,Wen P,Yang G,Feng Y,Mi Y,Wang X,Zhu S,Chen YQ
Tue Jul 19 00:00:00 EDT 2022
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
Phytotherapy research : PTR
Cheng L,Shi L,He C,Wang C,Lv Y,Li H,An Y,Dai H,Duan Y,Zhang H,Huang Y,Fu W,Meng Y,Zhao B
Wed Jun 01 00:00:00 EDT 2022
PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40.
Cell death & disease
Zhang T,Wang Y,Yu H,Zhang T,Guo L,Xu J,Wei X,Wang N,Wu Y,Wang X,Huang L
Thu Jan 20 00:00:00 EST 2022
Legumain affects the PI3K/AKT tumor progression pathway in retinoblastoma.
Experimental eye research
Tang Q,Xu F,Lin J,Zhang C,Liu X,Dong L,Zhao J,Zhu L,Lin T
Tue Nov 01 00:00:00 EDT 2022
Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K/AKT/mTOR signaling pathway.
Phytotherapy research : PTR
Zhai Y,Sun J,Sun C,Zhao H,Li X,Yao J,Su J,Xu X,Xu X,Hu J,Daglia M,Han B,Kai G
Tue Nov 01 00:00:00 EDT 2022
MED16 Promotes Tumour Progression and Tamoxifen Sensitivity by Modulating Autophagy through the mTOR Signalling Pathway in ER-Positive Breast Cancer.
Life (Basel, Switzerland)
Li H,Li K,Shu D,Shen M,Tan Z,Zhang W,Pu D,Tan W,Tang Z,Jin A,Liu S
Tue Sep 20 00:00:00 EDT 2022
Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model.
Frontiers in aging neuroscience
Sun W,Wen M,Liu M,Wang Q,Liu Q,Li L,Siebert HC,Loers G,Zhang R,Zhang N
Thu Dec 22 00:00:00 EST 2022
KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells.
BMC medical genomics
Li B,Ge N,Pan Z,Hou C,Xie K,Wang D,Liu J,Wan J,Deng F,Li M,Luo S
Tue Sep 13 00:00:00 EDT 2022
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
Frontiers in oncology
Liu H,Zhao L,Wang M,Yang K,Jin Z,Zhao C,Shi G
Sat Apr 09 00:00:00 EDT 2022
Shexiang Tongxin Dropping Pills Promote Macrophage Polarization-Induced Angiogenesis Against Coronary Microvascular Dysfunction via PI3K/Akt/mTORC1 Pathway.
Frontiers in pharmacology
Lu X,Yao J,Li C,Cui L,Liu Y,Liu X,Wang G,Dong J,Deng Q,Hu Y,Guo D,Wang W,Li C
Wed Apr 13 00:00:00 EDT 2022
Effects of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione on autophagy and the PI3K/AKT/mTOR signaling pathway in human cholangiocarcinoma QBC939 cells.
Journal of gastrointestinal oncology
He Y,Li Y,Liang T,Mo S,Liao Y,Chen Z,Zhao S,Ran Q,Han C,Hoa PTT
Wed Jun 01 00:00:00 EDT 2022
Transformer 2 alpha homolog is a downstream gene of hypoxia-inducible factor 1 subunit alpha and is involved in the progression of pancreatic cancer.
Bioengineered
Cao W,Lei S,Zeng Z,Xiao C,Sun B,Xie P,Li Y,Luo D,Yu W
Sun May 01 00:00:00 EDT 2022
Siah1 promotes the proliferation of NSCLC cells through ubiquitinating and stabilizing Notch1.
Experimental cell research
Liu Y,Li Q,Geng L,Zhou X,Zhou X,Dong Y,Zhang Y
Sat Oct 01 00:00:00 EDT 2022
Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity.
Cell death & disease
Wang R,Shang Y,Chen B,Xu F,Zhang J,Zhang Z,Zhao X,Wan X,Xu A,Wu L,Zhao G
Thu Oct 06 00:00:00 EDT 2022
Dapagliflozin Improves Cardiac Function, Remodeling, Myocardial Apoptosis, and Inflammatory Cytokines in Mice with Myocardial Infarction.
Journal of cardiovascular translational research
Wang K,Li Z,Sun Y,Liu X,Ma W,Ding Y,Hong J,Qian L,Xu D
Mon Aug 01 00:00:00 EDT 2022
HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway.
Frontiers in oncology
Wang H,Chen Y,Yuan Q,Chen L,Dai P,Li X
Tue Jan 03 00:00:00 EST 2023
CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas.
Molecular carcinogenesis
Fang J,Ma Y,Li Y,Li J,Zhang X,Han X,Ma S,Guan F
Tue Nov 01 00:00:00 EDT 2022
Hua-Tan-Sheng-Jing Decoction Treats Obesity With Oligoasthenozoospermia by Up-Regulating the PI3K-AKT and Down-Regulating the JNK MAPK Signaling Pathways: At the Crossroad of Obesity and Oligoasthenozoospermia.
Frontiers in pharmacology
Dong Y,Zheng Y,Zhu L,Li T,Guan Y,Zhao S,Wang Q,Wang J,Li L
Sat Jul 16 00:00:00 EDT 2022
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
International journal of environmental research and public health
Niu Z,Lin J,Hao C,Xu X,Wang C,Dai K,Deng X,Deng M,Guo Y,Yao W
Mon Jul 18 00:00:00 EDT 2022
CENPO regulated proliferation and apoptosis of colorectal cancer in a p53-dependent manner.
Discover. Oncology
Liu Z,Chen C,Yan M,Zeng X,Zhang Y,Lai D
Thu Feb 03 00:00:00 EST 2022
Synergistic effects of nab-PTX and anti-PD-1 antibody combination against lung cancer by regulating the Pi3K/AKT pathway through the Serpinc1 gene.
Frontiers in oncology
Zhang J,Tang Z,Guo X,Wang Y,Zhou Y,Cai W
Wed Nov 29 00:00:00 EST 2023
Hexokinase 2-mediated glycolysis promotes receptor activator of NF-κB ligand expression in Porphyromonas gingivalis lipopolysaccharide-treated osteoblasts.
Journal of periodontology
Yu Y,Jiang L,Li J,Lei L,Li H
Fri Jul 01 00:00:00 EDT 2022
TNFSF9 promotes metastasis of pancreatic cancer by regulating M2 polarization of macrophages through Src/FAK/p-Akt/IL-1β signaling.
International immunopharmacology
Wu J,Wang Y,Yang Y,Liu F,Jiang Z,Jiang Z
Sat Jan 01 00:00:00 EST 2022
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
Pharmaceuticals (Basel, Switzerland)
Sun Y,Li H,Liu L,Bai X,Wu L,Shan J,Sun X,Wang Q,Guo Y
Thu Dec 29 00:00:00 EST 2022
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
Cell biology and toxicology
Wang H,Ai J,Shopit A,Niu M,Ahmed N,Tesfaldet T,Tang Z,Li X,Jamalat Y,Chu P,Peng J,Ma X,Qaed E,Han G,Zhang W,Wang J,Tang Z
Wed Jun 01 00:00:00 EDT 2022
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification.
Drug design, development and therapy
Shu W,Wang Z,Zhao R,Shi R,Zhang J,Zhang W,Wang H
Fri Jun 24 00:00:00 EDT 2022
KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation.
The Journal of investigative dermatology
Zhou Q,Gong J,Bi J,Yang X,Zhang L,Lu C,Li L,Chen M,Cai J,Yang R,Li X,Li Z,Wang X
Fri Jul 01 00:00:00 EDT 2022
The inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters.
Chinese medicine
Huang W,Wen F,Gu P,Liu J,Xia Y,Li Y,Zhou J,Song S,Ruan S,Gu S,Chen X,Shu P
Tue Aug 09 00:00:00 EDT 2022
CLDN4 promotes growth of acute myeloid leukemia cells via regulating AKT and ERK1/2 signaling.
Biochemical and biophysical research communications
Hao S,Yang C,Song P,Shi H,Zou Y,Chen M,Wu X,Yin Y,Yu Z,Zhu W,Li M
Sat Sep 03 00:00:00 EDT 2022
Long noncoding RNA BMPR1B-AS1 facilitates endometrial cancer cell proliferation and metastasis by sponging miR-7-2-3p to modulate the DCLK1/Akt/NF-κB pathway.
Cell cycle (Georgetown, Tex.)
Lai T,Qiu H,Si L,Zhen Y,Chu D,Guo R
Mon Aug 01 00:00:00 EDT 2022
The GBM Tumor Microenvironment as a Modulator of Therapy Response: ADAM8 Causes Tumor Infiltration of Tams through HB-EGF/EGFR-Mediated CCL2 Expression and Overcomes TMZ Chemosensitization in Glioblastoma.
Cancers
Liu X,Huang Y,Qi Y,Wu S,Hu F,Wang J,Shu K,Zhang H,Bartsch JW,Nimsky C,Dong F,Lei T
Fri Oct 07 00:00:00 EDT 2022
Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1α Inhibition.
Frontiers in cardiovascular medicine
Osuru HP,Lavallee M,Thiele RH
Sat Aug 06 00:00:00 EDT 2022
TRAF4 Promotes the Proliferation of Glioblastoma by Stabilizing SETDB1 to Activate the AKT Pathway.
International journal of molecular sciences
Gu H,Zhu S,Peng C,Wei Z,Shen Y,Yuan C,Yang H,Cui H,Yang L
Mon Sep 05 00:00:00 EDT 2022
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Fitoterapia
Fan Y,Wu H,Xiong L,Luo F,Li Q,Wang D,Zhong T
Tue Nov 01 00:00:00 EDT 2022
Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway.
Experimental cell research
Wang J,Luo X,Lu J,Wang X,Miao Y,Li Q,Wang L
Fri Jul 15 00:00:00 EDT 2022
Therapeutic Potential of Astragaloside IV Against Adriamycin-Induced Renal Damage in Rats via Ferroptosis.
Frontiers in pharmacology
Qin LY,Guan P,Wang JX,Chen Y,Zhao YS,Yang SC,Guo YJ,Wang N,Ji ES
Tue Apr 05 00:00:00 EDT 2022
ANGPTL8 is a negative regulator in pathological cardiac hypertrophy.
Cell death & disease
Hu L,Wei J,Zhang Y,Wang Z,Tang J,Tang J,Gao Y,Zhang X,Li Y,Liu Y,Ma S,Guo X,Zhang Q
Mon Jul 18 00:00:00 EDT 2022
Inhibition of SRPK1, a key splicing regulator, exhibits antitumor and chemotherapeutic-sensitizing effects on extranodal NK/T-cell lymphoma cells.
BMC cancer
He C,Liu B,Wang HY,Wu L,Zhao G,Huang C,Liu Y,Shan B,Liu L
Thu Oct 27 00:00:00 EDT 2022
Circadian Period 2 (Per2) downregulate inhibitor of differentiation 3 (Id3) expression via PTEN/AKT/Smad5 axis to inhibits glioma cell proliferation.
Bioengineered
Zhang Y,Hu X,Li H,Yao J,Yang P,Lan Y,Xia H
Sun May 01 00:00:00 EDT 2022
Jiedu Tongluo Baoshen formula enhances podocyte autophagy and reduces proteinuria in diabetic kidney disease by inhibiting PI3K/Akt/mTOR signaling pathway.
Journal of ethnopharmacology
Jin D,Liu F,Yu M,Zhao Y,Yan G,Xue J,Sun Y,Zhao D,Li X,Qi W,Wang X
Fri Jul 15 00:00:00 EDT 2022
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Frontiers in endocrinology
Lu R,He Z,Zhang W,Wang Y,Cheng P,Lv Z,Yuan X,Guo F,You H,Chen AM,Hu W
Tue Dec 20 00:00:00 EST 2022
Inhibition of FAM83D displays antitumor effects in glioblastoma via down-regulation of the AKT/Wnt/β-catenin pathway.
Environmental toxicology
Wang J,Quan Y,Lv J,Gong S,Ren P
Wed Jun 01 00:00:00 EDT 2022
Kaempferol prevents angiogenesis of rat intestinal microvascular endothelial cells induced by LPS and TNF-α via inhibiting VEGF/Akt/p38 signaling pathways and maintaining gut-vascular barrier integrity.
Chemico-biological interactions
Yu R,Zhong J,Zhou Q,Ren W,Liu Z,Bian Y
Sat Oct 01 00:00:00 EDT 2022
The anti-fatigue activity of corn peptides and their effect on gut bacteria.
Journal of the science of food and agriculture
Feng Z,Wei Y,Xu Y,Zhang R,Li M,Qin H,Gu R,Cai M
Wed Jun 01 00:00:00 EDT 2022
Vitamin D3 promotes autophagy in THP-1 cells infected with Mycobacterium tuberculosis.
Experimental and therapeutic medicine
Wu Y,Lin X,Song F,Xue D,Wang Y
Tue Mar 01 00:00:00 EST 2022
Mechanism of Tripterygium wilfordii Hook.F.- Trichosanthes kirilowii Maxim decoction in treatment of diabetic kidney disease based on network pharmacology and molecular docking.
Frontiers in pharmacology
Lu L,Peng J,Wan P,Peng H,Lu J,Xiong G
Fri Nov 18 00:00:00 EST 2022
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
Journal of gastrointestinal oncology
Yin L,Feng S,Sun Y,Jiang Y,Tang C,Sun D
Sat Oct 01 00:00:00 EDT 2022
Network pharmacology and experimental analysis to reveal the mechanism of Dan-Shen-Yin against endothelial to mesenchymal transition in atherosclerosis.
Frontiers in pharmacology
Hong M,Wu Y,Zhang H,Gu J,Chen J,Guan Y,Qin X,Li Y,Cao J
Tue Sep 13 00:00:00 EDT 2022
Impact of Resolvin D1 on the inflammatory phenotype of periodontal ligament cell response to hypoxia.
Journal of periodontal research
Cai J,Liu J,Yan J,Lu X,Wang X,Li S,Mustafa K,Wang H,Xue Y,Mustafa M,Kantarci A,Xing Z
Sat Oct 01 00:00:00 EDT 2022
Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.
Proceedings of the National Academy of Sciences of the United States of America
An W,Lin H,Ma L,Zhang C,Zheng Y,Cheng Q,Ma C,Wu X,Zhang Z,Zhong Y,Wang M,He D,Yang Z,Du L,Feng S,Wang C,Yang F,Xiao P,Zhang P,Yu X,Sun JP
Tue Apr 12 00:00:00 EDT 2022
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Stem cell research & therapy
Yin BF,Li ZL,Yan ZQ,Guo Z,Liang JW,Wang Q,Zhao ZD,Li PL,Hao RC,Han MY,Li XT,Mao N,Ding L,Chen DF,Gao Y,Zhu H
Tue Jun 07 00:00:00 EDT 2022
A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction.
Advanced healthcare materials
Zheng Z,Lei C,Liu H,Jiang M,Zhou Z,Zhao Y,Yu CY,Wei H
Sat Oct 01 00:00:00 EDT 2022
Puffball spores improve wound healing in a diabetic rat model.
Frontiers in endocrinology
He T,Sun P,Liu B,Wan S,Fang P,Chen J,Huang G,Min W
Tue Sep 20 00:00:00 EDT 2022
Prediction of the Mechanism of Shaoyao Gancao Decoction in the Treatment of Alopecia Areata by Network Pharmacology and Its Preliminary Verification Study.
Evidence-based complementary and alternative medicine : eCAM
Lv S,Wang L,Duan Y,Huang D,Yang D
Sat Jul 16 00:00:00 EDT 2022
Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic/reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways.
Pharmacological research
Cai J,Liang J,Zhang Y,Shen L,Lin H,Hu T,Zhan S,Xie M,Liang S,Xian M,Wang S
Wed Jun 01 00:00:00 EDT 2022
Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway.
Cancer medicine
Ying J,Pan R,Tang Z,Zhu J,Ren P,Lou Y,Zhang E,Huang D,Hu P,Li D,Bao Q,Li P
Tue Mar 01 00:00:00 EST 2022
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR-144-3p/IGF2R axis.
Drug development research
Yuan D,Guo T,Qian H,Ge H,Zhao Y,Huang A,Wang X,Cao X,Zhu D,He C,Yu H
Thu Sep 01 00:00:00 EDT 2022
Mesenchyme homeobox 2 has a cancer-inhibiting function in breast carcinoma via affection of the PI3K/AKT/mTOR and ERK1/2 pathways.
Biochemical and biophysical research communications
Cai Y,Liu Y,Sun Y,Ren Y
Sat Feb 19 00:00:00 EST 2022
MiR-574-5p promotes cell proliferation by negatively regulating small C-terminal domain phosphatase 1 in esophageal squamous cell carcinoma.
Iranian journal of basic medical sciences
Zhao C,Liu J,Xu Y,Guo J,Wang L,Chen L,Xu L,Dong G,Zheng W,Li Z,Cai H,Li S
Sat Oct 01 00:00:00 EDT 2022
Depletion of PARP10 inhibits the growth and metastatic potential of oral squamous cell carcinoma.
Frontiers in genetics
Zhou Z,Wei B,Liu Y,Liu T,Zeng S,Gan J,Qi G
Wed Nov 02 00:00:00 EDT 2022
Taurine attenuates neuronal ferroptosis by regulating GABAB/AKT/GSK3β/β-catenin pathway after subarachnoid hemorrhage.
Free radical biology & medicine
Liu C,He P,Guo Y,Tian Q,Wang J,Wang G,Zhang Z,Li M
Sun Nov 20 00:00:00 EST 2022
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora.
Journal of inflammation research
Hao M,Ding C,Sun S,Peng X,Liu W
Wed Sep 07 00:00:00 EDT 2022
Exploring the Effective Components and Mechanism of Action of Japanese Ardisia in the Treatment of Autoimmune Hepatitis Based on Network Pharmacology and Experimental Verification.
Pharmaceuticals (Basel, Switzerland)
Fu T,Chen Y,Li J,Zhu P,He H,Zhang W,Yung KKL,Wu W
Thu Nov 24 00:00:00 EST 2022
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Shen Y,Fan X,Qu Y,Tang M,Huang Y,Peng Y,Fu Q
Thu Sep 01 00:00:00 EDT 2022
COL11A1-Driven Epithelial-Mesenchymal Transition and Stemness of Pancreatic Cancer Cells Induce Cell Migration and Invasion by Modulating the AKT/GSK-3β/Snail Pathway.
Biomolecules
Wang H,Zhou H,Ni H,Shen X
Wed Mar 02 00:00:00 EST 2022
YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts.
Biochimica et biophysica acta. Molecular basis of disease
Shen T,Li Y,Wang D,Su Y,Li G,Shang Z,Niu Y,Tan X
Thu Dec 01 00:00:00 EST 2022
Ascorbic acid 2-glucoside preconditioning enhances the ability of bone marrow mesenchymal stem cells in promoting wound healing.
Stem cell research & therapy
Yi Y,Wu M,Zhou X,Xiong M,Tan Y,Yu H,Liu Z,Wu Y,Zhang Q
Mon Mar 21 00:00:00 EDT 2022
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Frontiers in pharmacology
Fan XX,Sun WY,Li Y,Tang Q,Li LN,Yu X,Wang SY,Fan AR,Xu XQ,Chang HS
Tue Sep 13 00:00:00 EDT 2022
An oleanolic acid derivative, K73-03, inhibits pancreatic cancer cells proliferation in vitro and in vivo via blocking EGFR/Akt pathway.
Cell biology international
Zhou Z,Dong Y,Li N,Niu M,Wang S,Zhou Y,Sun Z,Chu P,Tang Z
Tue Nov 01 00:00:00 EDT 2022
AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer.
Molecular nutrition & food research
Huang L,He C,Zheng S,Wu C,Ren M,Shan Y
Tue Feb 01 00:00:00 EST 2022
Sodium butyrate attenuates bovine mammary epithelial cell injury by inhibiting the formation of neutrophil extracellular traps.
International immunopharmacology
Li Y,Liu J,Cui Y,Cao Y,Xu P,Kan X,Guo W,Fu S
Thu Sep 01 00:00:00 EDT 2022
Guanxinping Tablets Inhibit ET-1-Induced Proliferation and Migration of MOVAS by Suppressing Activated PI3K/Akt/NF-κB Signaling Cascade.
Evidence-based complementary and alternative medicine : eCAM
Wu YY,Huang YL,Dai B,Liu JW,Han X
Sat Jul 16 00:00:00 EDT 2022
Interleukin 33-mediated inhibition of A-type K+ channels induces sensory neuronal hyperexcitability and nociceptive behaviors in mice.
Theranostics
Wang Y,Wang X,Qi R,Lu Y,Tao Y,Jiang D,Sun Y,Jiang X,Liu C,Zhang Y,Tao J
Thu Apr 21 00:00:00 EDT 2022
Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke.
Cell reports
Luo F,Wang J,Zhang Z,You Z,Bedolla A,Okwubido-Williams F,Huang LF,Silver J,Luo Y
Tue Jul 26 00:00:00 EDT 2022
l-Arginine prevents 4-hydroxy-2-nonenal accumulation and depresses inflammation via inhibiting NF-κB activation.
Journal of biochemical and molecular toxicology
Liang M,Wang Z,Li H,Liu B,Yang L
Mon Aug 01 00:00:00 EDT 2022
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Experimental dermatology
Tao T,Chen Y,Chen J,Lian C,Xu S,Zhang M,Fang C
Mon Aug 01 00:00:00 EDT 2022
HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway.
Frontiers in cell and developmental biology
Shen G,Wang H,Zhu N,Lu Q,Liu J,Xu Q,Huang D
Sat Jul 16 00:00:00 EDT 2022
Taurine Ameliorates Apoptosis via AKT Pathway in the Kidney of Diabetic Rats.
Advances in experimental medicine and biology
Li S,Wang D,Zhang M,Zhang C,Piao F
Thu Jul 28 00:00:00 EDT 2022
Exploring the pharmacological mechanism of calculus bovis in cerebral ischaemic stroke using a network pharmacology approach.
Journal of ethnopharmacology
Du X,Li C,Zhang S,Sun C,Zhang X,Chen C,Wang X,Cheng F,Wang Q
Thu Feb 10 00:00:00 EST 2022
Exploring Active Ingredients, Beneficial Effects, and Potential Mechanism of Allium tenuissimum L. Flower for Treating T2DM Mice Based on Network Pharmacology and Gut Microbiota.
Nutrients
Zhang SS,Hou YF,Liu SJ,Guo S,Ho CT,Bai NS
Sun Sep 25 00:00:00 EDT 2022
METTL3-Mediated m6A Modification of lncRNA MALAT1 Facilitates Prostate Cancer Growth by Activation of PI3K/AKT Signaling.
Cell transplantation
Mao Y,Li W,Weng Y,Hua B,Gu X,Lu C,Xu B,Xu H,Wang Z
Fri Sep 09 00:00:00 EDT 2022
Protective Effect of Resveratrol on Immortalized Duck Intestinal Epithelial Cells Exposed to H2O2.
Molecules (Basel, Switzerland)
Zhou N,Tian Y,Wu H,Cao Y,Li R,Zou K,Xu W,Lu L
Tue May 31 00:00:00 EDT 2022
Xiao-Chai-Hu Decoction Ameliorates Poly (I:C)-Induced Viral Pneumonia through Inhibiting Inflammatory Response and Modulating Serum Metabolism.
Evidence-based complementary and alternative medicine : eCAM
Chen F,Qu F,Jia Y,Wang C,Yu Y,Liao J,Lin M,Chen F,Sun Z
Sat Jul 23 00:00:00 EDT 2022
Human CPTP promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells.
International journal of biological sciences
Zhang Y,Ji S,Zhang X,Lu M,Hu Y,Han Y,Shui G,Lam SM,Zou X
Mon Aug 22 00:00:00 EDT 2022
Neuregulin-1β increases glucose uptake and promotes GLUT4 translocation in palmitate-treated C2C12 myotubes by activating PI3K/AKT signaling pathway.
Frontiers in pharmacology
Yu M,Wu S,Gong C,Chen L
Thu Feb 02 00:00:00 EST 2023
Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer's Disease Mice.
Neural plasticity
Peng Y,Chi R,Liu G,Tian W,Zhang J,Zhang R
Thu Sep 22 00:00:00 EDT 2022
Network Pharmacology-Based Prediction and Verification of the Potential Targets of Pinoresinol Diglucoside for OA Treatment.
Evidence-based complementary and alternative medicine : eCAM
Lou H,Zhang Y,Fang J,Jin Y
Sat Jul 16 00:00:00 EDT 2022
The neuroprotective effects of phosphocreatine on amyloid beta 25-35-induced differentiated neuronal cell death through inhibition of AKT/GSK-3β /Tau/APP/CDK5 pathways in vivo and vitro.
Free radical biology & medicine
Ai J,Wang H,Chu P,Shopit A,Niu M,Ahmad N,Tesfaldet T,Wang FH,Fang JN,Li X,Tang SJ,Han QJ,Han G,Peng J,Tang Z
Tue Feb 01 00:00:00 EST 2022
Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Melanoma and Liver Tumors.
Journal of immunology research
Zhang M,Wang L,Liu W,Wang T,De Sanctis F,Zhu L,Zhang G,Cheng J,Cao Q,Zhou J,Tagliabue A,Bronte V,Yan D,Wan X,Yu G
Wed Jul 06 00:00:00 EDT 2022
The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblast.
Journal of reproductive immunology
Wu S,Liu H,Zhou M,Shang Y,Luo L,Chen J,Yang J
Mon Aug 01 00:00:00 EDT 2022
Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway.
Journal of ginseng research
Ni J,Liu Z,Jiang M,Li L,Deng J,Wang X,Su J,Zhu Y,He F,Mao J,Gao X,Fan G
Tue Mar 01 00:00:00 EST 2022
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
International journal of biological macromolecules
Liu Y,Xu Z,Huang H,Xue Y,Zhang D,Zhang Y,Li W,Li X
Tue Mar 15 00:00:00 EDT 2022
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Food & function
Liu Y,Huang H,Xu Z,Xue Y,Zhang D,Zhang Y,Li W,Li X
Mon Mar 07 00:00:00 EST 2022
Network Pharmacology-Based Strategy to Identify the Pharmacological Mechanisms of Pulsatilla Decoction against Crohn's Disease.
Frontiers in pharmacology
Liu J,Zhang L,Wang Z,Chen S,Feng S,He Y,Zhang S
Sat Jul 16 00:00:00 EDT 2022
Protective effects of Huang-Lian-Jie-Du Decoction on diabetic nephropathy through regulating AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling in db/db mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Tang D,He WJ,Zhang ZT,Shi JJ,Wang X,Gu WT,Chen ZQ,Xu YH,Chen YB,Wang SM
Sat Jan 01 00:00:00 EST 2022
LRPPRC inhibits autophagy and promotes foam cell formation in atherosclerosis.
The FEBS journal
Xu Z,Li X,Ding Z,Zhang Y,Peng Z,Yang X,Cao W,Du R
Thu Dec 01 00:00:00 EST 2022
Momordica. charantia-Derived Extracellular Vesicles-Like Nanovesicles Protect Cardiomyocytes Against Radiation Injury via Attenuating DNA Damage and Mitochondria Dysfunction.
Frontiers in cardiovascular medicine
Cui WW,Ye C,Wang KX,Yang X,Zhu PY,Hu K,Lan T,Huang LY,Wang W,Gu B,Yan C,Ma P,Qi SH,Luo L
Sat May 07 00:00:00 EDT 2022
Extracellular Vesicles from BMSCs Prevent Glucocorticoid-Induced BMECs Injury by Regulating Autophagy via the PI3K/Akt/mTOR Pathway.
Cells
Ma J,Shen M,Yue D,Wang W,Gao F,Wang B
Sun Jul 03 00:00:00 EDT 2022
Hypoxia Enhances Activity and Malignant Behaviors of Colorectal Cancer Cells through the STAT3/MicroRNA-19a/PTEN/PI3K/AKT Axis.
Analytical cellular pathology (Amsterdam)
Tang Y,Weng X,Liu C,Li X,Chen C
Mon Mar 07 00:00:00 EST 2022
Nr2e1 deficiency aggravates insulin resistance and chronic inflammation of visceral adipose tissues in a diet-induced obese mice model.
Life sciences
He G,Gu J,Wang H,Cheng S,Xiong Q,Ke M,Hu Y,Feng J,Song L,Liu Z,Xu Y
Sun Aug 01 00:00:00 EDT 2021
Protective effects of safranal on hypoxia/reoxygenation-induced injury in H9c2 cardiac myoblasts via the PI3K/AKT/GSK3β signaling pathway.
Experimental and therapeutic medicine
Wang H,Zheng B,Che K,Han X,Li L,Wang H,Liu Y,Shi J,Sun S
Wed Dec 01 00:00:00 EST 2021
The mechanism and candidate compounds of aged citrus peel (chenpi) preventing chronic obstructive pulmonary disease and its progression to lung cancer.
Food & nutrition research
Zhou L,Gu W,Kui F,Gao F,Niu Y,Li W,Zhang Y,Guo L,Wang J,Guo Z,Du G
Sun Apr 24 00:00:00 EDT 2022
The mechanism and candidate compounds of aged citrus peel (chenpi) preventing chronic obstructive pulmonary disease and its progression to lung cancer.
Food & nutrition research
Zhou L,Gu W,Kui F,Gao F,Niu Y,Li W,Zhang Y,Guo L,Wang J,Guo Z,Du G
Sun Apr 24 00:00:00 EDT 2022
Qingjie Fuzheng Granule suppresses lymphangiogenesis in colorectal cancer via the VEGF-C/VEGFR-3 dependent PI3K/AKT pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Huang B,Lu Y,Gui M,Guan J,Lin M,Zhao J,Mao Q,Lin J
Sat May 01 00:00:00 EDT 2021
Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.
Frontiers in pharmacology
Pei W,Huang X,Ni B,Zhang R,Niu G,You H
Sat Oct 16 00:00:00 EDT 2021
Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells.
Frontiers in pharmacology
Li G,Zhong Y,Wang W,Jia X,Zhu H,Jiang W,Song Y,Xu W,Wu S
Sat Dec 18 00:00:00 EST 2021
Cox-2 Antagonizes the Protective Effect of Sevoflurane on Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis through Inhibiting the Akt Pathway.
Disease markers
Guo C,Zhang L,Gao Y,Sun J,Fan L,Bai Y,Zhang J,Naren G,Yang J,Li L
Mon Mar 14 00:00:00 EDT 2022
The COL11A1/Akt/CREB signaling axis enables mitochondrial-mediated apoptotic evasion to promote chemoresistance in pancreatic cancer cells through modulating BAX/BCL-2 function.
Journal of Cancer
Wang H,Ren R,Yang Z,Cai J,Du S,Shen X
Sat Feb 06 00:00:00 EST 2021
Overexpression of PTPRN Promotes Metastasis of Lung Adenocarcinoma and Suppresses NK Cell Cytotoxicity.
Frontiers in cell and developmental biology
Song X,Jiao X,Yan H,Yu L,Jiang L,Zhang M,Chen L,Ju M,Wang L,Wei Q,Zhao L,Wei M
Sun Apr 24 00:00:00 EDT 2022
PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia.
Journal of cellular physiology
Ma D,Liu P,Wang P,Zhou Z,Fang Q,Wang J
Wed Sep 01 00:00:00 EDT 2021
Autophagic Inhibition of Caveolin-1 by Compound Phyllanthus urinaria L. Activates Ubiquitination and Proteasome Degradation of β-catenin to Suppress Metastasis of Hepatitis B-Associated Hepatocellular Carcinoma.
Frontiers in pharmacology
Huang D,Yang B,Yao Y,Liao M,Zhang Y,Zeng Y,Zhang F,Wang N,Tong G
Sat Jun 26 00:00:00 EDT 2021
Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro.
Journal of ethnopharmacology
Tang L,Wang F,Xiao L,Shen M,Xia S,Zhang Z,Zhang F,Zheng S,Tan S
Mon Nov 15 00:00:00 EST 2021
OM-MSCs Alleviate the Golgi Apparatus Stress Response following Cerebral Ischemia/Reperfusion Injury via the PEDF-PI3K/Akt/mTOR Signaling Pathway.
Oxidative medicine and cellular longevity
He J,Liu J,Huang Y,Tang X,Xiao H,Liu Z,Jiang Z,Zeng L,Hu Z,Lu M
Mon Feb 07 00:00:00 EST 2022
SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/β-catenin pathway.
Journal of cellular and molecular medicine
Chen W,Zhao S,Yu W,Rao T,Ruan Y,Zhu S,Xia Y,Song H,Cheng F
Mon Nov 01 00:00:00 EDT 2021
Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening.
Frontiers in pharmacology
Liao W,Yang W,Xu J,Yan Z,Pan M,Xu X,Zhou S,Zhu Y,Lan J,Zeng M,Han X,Li S,Li Y,Liang K,Gao Y,Peng Q
Wed Nov 17 00:00:00 EST 2021
Nrf2 Activation Is Involved in Cyclic Mechanical Stress-Stimulated Osteogenic Differentiation in Periodontal Ligament Stem Cells via PI3K/Akt Signaling and HO1-SOD2 Interaction.
Frontiers in cell and developmental biology
Xi X,Li Z,Liu H,Chen S,Liu D
Tue Jan 25 00:00:00 EST 2022
Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
IUBMB life
Wang L,Chen X,Wang L,Wang S,Li W,Liu Y,Zhang J
Mon Nov 01 00:00:00 EDT 2021
Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells.
Marine drugs
Hou JR,Wang YH,Zhong YN,Che TT,Hu Y,Bao J,Meng N
Sat Dec 18 00:00:00 EST 2021
Lipidomic Alterations and PPARα Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models.
Oxidative medicine and cellular longevity
Chen Z,Wang C,Lin C,Zhang L,Zheng H,Zhou Y,Li X,Li C,Zhang X,Yang X,Guan M,Xi Y
Tue Feb 15 00:00:00 EST 2022
NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer.
Biochemical and biophysical research communications
Lin F,Zhou J,Li X,Wang X
Fri Jun 25 00:00:00 EDT 2021
Autophagy Blockade by Ai Du Qing Formula Promotes Chemosensitivity of Breast Cancer Stem Cells Via GRP78/β-Catenin/ABCG2 Axis.
Frontiers in pharmacology
Liao M,Wang C,Yang B,Huang D,Zheng Y,Wang S,Wang X,Zhang J,Tang C,Xu Z,He Y,Huang R,Zhang F,Wang Z,Wang N
Wed Mar 09 00:00:00 EST 2022
Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus.
ACS chemical neuroscience
Sun Y,Zhang H,Wu Z,Yu X,Yin Y,Qian S,Wang Z,Huang J,Wang W,Liu T,Xue W,Chen G
Wed Sep 15 00:00:00 EDT 2021
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Journal of agricultural and food chemistry
Zhang Q,Su G,Yang Q,Wei Z,Wang J,Zheng L,Zhao M
Wed Sep 15 00:00:00 EDT 2021
Targeting cancer cell plasticity by HDAC inhibition to reverse EBV-induced dedifferentiation in nasopharyngeal carcinoma.
Signal transduction and targeted therapy
Xie J,Wang Z,Fan W,Liu Y,Liu F,Wan X,Liu M,Wang X,Zeng D,Wang Y,He B,Yan M,Zhang Z,Zhang M,Hou Z,Wang C,Kang Z,Fang W,Zhang L,Lam EW,Guo X,Yan J,Zeng Y,Chen M,Liu Q
Sat Sep 04 00:00:00 EDT 2021
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
Bioorganic chemistry
Ma Y,Yang X,Han H,Wen Z,Yang M,Zhang Y,Fu J,Wang X,Yin T,Lu G,Qi J,Lin H,Wang X,Yang Y
Tue Jun 01 00:00:00 EDT 2021
CYP2C8 Suppress Proliferation, Migration, Invasion and Sorafenib Resistance of Hepatocellular Carcinoma via PI3K/Akt/p27kip1 Axis.
Journal of hepatocellular carcinoma
Zhou X,Li TM,Luo JZ,Lan CL,Wei ZL,Fu TH,Liao XW,Zhu GZ,Ye XP,Peng T
Thu Apr 28 00:00:00 EDT 2022
Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.
Journal of immunology research
Song M,Li ZH,Gu HS,Tang RY,Zhang R,Zhu YL,Liu JL,Zhang JJ,Wang LY
Thu Nov 11 00:00:00 EST 2021
B7-H3 inhibits apoptosis of gastric cancer cell by interacting with Fibronectin.
Journal of Cancer
Sun M,Xie J,Zhang D,Chen C,Lin S,Chen Y,Zhang G
Sat Feb 19 00:00:00 EST 2022
Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway.
Science China. Life sciences
Feng Y,Cao X,Zhao B,Song C,Pang B,Hu L,Zhang C,Wang J,He J,Wang S
Mon Nov 01 00:00:00 EDT 2021
The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments.
European review for medical and pharmacological sciences
Hou Y,Li FZ
Wed Dec 01 00:00:00 EST 2021
Tuftelin 1 (TUFT1) Promotes the Proliferation and Migration of Renal Cell Carcinoma via PI3K/AKT Signaling Pathway.
Pathology oncology research : POR
Lin H,Zeng W,Lei Y,Chen D,Nie Z
Mon Jan 03 00:00:00 EST 2022
FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling.
Gene
Smith AL,Gjoka E,Izhar M,Novo KJ,Mason BC,De Las Casas A,Waddell DS
Wed Oct 20 00:00:00 EDT 2021
Functions of Forkhead Box O on Glucose Metabolism in Abalone Haliotis discus hannai and Its Responses to High Levels of Dietary Lipid.
Genes
Wang L,Guo Y,Pan M,Li X,Huang D,Liu Y,Wu C,Zhang W,Mai K
Sat Feb 20 00:00:00 EST 2021
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Alcohol (Fayetteville, N.Y.)
Chen M,Sun X,Wei W,Cucarella C,Martín-Sanz P,Casado M,Pi L,Ren B,Cao Q
Sat May 01 00:00:00 EDT 2021
Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage.
Translational oncology
Niu LT,Wang YQ,Wong CCL,Gao SX,Mo XD,Huang XJ
Wed Sep 01 00:00:00 EDT 2021
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
Journal of bone oncology
Guo H,Peng J,Hu J,Chang S,Liu H,Luo H,Chen X,Tang H,Chen Y
Wed Dec 01 00:00:00 EST 2021
Mice lacking the proton channel Hv1 exhibit sex-specific differences in glucose homeostasis.
The Journal of biological chemistry
Pang H,Li J,Wang Y,Su X,Gao Y,Li SJ
Fri Oct 01 00:00:00 EDT 2021
Lack of Mof reduces acute liver injury by enhancing transcriptional activation of Igf1.
Journal of cellular physiology
Wang M,Liu H,Zhang X,Zhao W,Li D,Xu C,Wu Z,Xie F,Li X
Wed Sep 01 00:00:00 EDT 2021
Erianin, the main active ingredient of Dendrobium chrysotoxum Lindl, inhibits precancerous lesions of gastric cancer (PLGC) through suppression of the HRAS-PI3K-AKT signaling pathway as revealed by network pharmacology and in vitro experimental verification.
Journal of ethnopharmacology
Wang Y,Chu F,Lin J,Li Y,Johnson N,Zhang J,Gai C,Su Z,Cheng H,Wang L,Ding X
Thu Oct 28 00:00:00 EDT 2021
Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway.
Aging
Cao W,Zeng Z,He Z,Lei S
Fri Feb 26 00:00:00 EST 2021
Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling.
Clinical science (London, England : 1979)
Feng L,Que D,Li Z,Zhong X,Yan J,Wei J,Zhang X,Yang P,Ou C,Chen M
Fri Nov 12 00:00:00 EST 2021
Sodium alginate/collagen/stromal cell-derived factor-1 neural scaffold loaded with BMSCs promotes neurological function recovery after traumatic brain injury.
Acta biomaterialia
Ma S,Zhou J,Huang T,Zhang Z,Xing Q,Zhou X,Zhang K,Yao M,Cheng T,Wang X,Wen X,Guan F
Wed Sep 01 00:00:00 EDT 2021
The Roles of Liver Inflammation and the Insulin Signaling Pathway in PM2.5 Instillation-Induced Insulin Resistance in Wistar Rats.
Disease markers
Zhang Z,Hu S,Fan P,Li L,Feng S,Xiao H,Zhu L
Wed Feb 23 00:00:00 EST 2022
A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation.
Chinese medicine
Wu C,Huang ZH,Meng ZQ,Fan XT,Lu S,Tan YY,You LM,Huang JQ,Stalin A,Ye PZ,Wu ZS,Zhang JY,Liu XK,Zhou W,Zhang XM,Wu JR
Mon Nov 22 00:00:00 EST 2021
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
Journal of cellular biochemistry
Zheng Y,Nie P,Xu S
Mon Jun 01 00:00:00 EDT 2020
AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer.
Cancer management and research
Xu F,Xu Y,Xiong JH,Zhang JH,Wu J,Luo J,Xiong JP
Wed Apr 13 00:00:00 EDT 2022
LMP1 promotes nasopharyngeal carcinoma metastasis through NTRK2-mediated anoikis resistance.
American journal of cancer research
Li Z,Zhou Z,Wu X,Zhou Q,Liao C,Liu Y,Li D,Shen L,Feng D,Yang L
Mon Sep 28 00:00:00 EDT 2020
PTPN3 Inhibits the Growth and Metastasis of Clear Cell Renal Cell Carcinoma via Inhibition of PI3K/AKT Signaling.
Molecular cancer research : MCR
Peng XS,Yang JP,Qiang YY,Sun R,Cao Y,Zheng LS,Peng LX,Lang YH,Mei Y,Li CZ,Meng DF,Liu ZJ,Wang MD,Zhou FJ,Huang BJ,Qian CN
Mon Jun 01 00:00:00 EDT 2020
Fam83d modulates MAP kinase and AKT signaling and is induced during neurogenic skeletal muscle atrophy.
Cellular signalling
Cooper LM,Hanson A,Kavanagh JA,Waddell DS
Mon Jun 01 00:00:00 EDT 2020
Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling.
Journal of ethnopharmacology
Li J,Ma J,Tian Y,Zhao P,Liu X,Dong H,Zheng W,Feng S,Zhang L,Wu M,Zhu L,Liu S,Zhao D
Wed Jul 15 00:00:00 EDT 2020
Ambient PM2.5 caused cardiac dysfunction through FoxO1-targeted cardiac hypertrophy and macrophage-activated fibrosis in mice.
Chemosphere
Su X,Tian J,Li B,Zhou L,Kang H,Pei Z,Zhang M,Li C,Wu M,Wang Q,Han B,Chu C,Pang Y,Ning J,Zhang B,Niu Y,Zhang R
Fri May 01 00:00:00 EDT 2020
BML-111 inhibits EMT, migration and metastasis of TAMs-stimulated triple-negative breast cancer cells via ILK pathway.
International immunopharmacology
Lin L,Luo X,Wang L,Xu F,He Y,Wang Q,Yuan C,Xu J,Yan L,Hao H
Sat Aug 01 00:00:00 EDT 2020
High PD‑L1 expression drives glycolysis via an Akt/mTOR/HIF‑1α axis in acute myeloid leukemia.
Oncology reports
Ma P,Xing M,Han L,Gan S,Ma J,Wu F,Huang Y,Chen Y,Tian W,An C,Sun H,Sun L
Sun Mar 01 00:00:00 EST 2020
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.
Human & experimental toxicology
Chen M,Zhu LL,Su JL,Li GL,Wang J,Zhang YN
Sat Feb 01 00:00:00 EST 2020
An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway.
Biology open
Yang ZY,Yang L,Xu CW,Wang XJ,Lei L
Fri Jan 24 00:00:00 EST 2020
Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma.
DNA and cell biology
Zhang J,Chen Y,Lin J,Jia R,An T,Dong T,Zhang Y,Yang X
Sun Mar 01 00:00:00 EST 2020
Susceptibility to Hyperglycemia in Rats With Stress-Induced Depressive-Like Behavior: Involvement of IL-6 Mediated Glucose Homeostasis Signaling.
Frontiers in psychiatry
Li X,Qiu W,Li N,Da X,Ma Q,Hou Y,Wang T,Song M,Chen J
Mon Sep 28 00:00:00 EDT 2020
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Clinical epigenetics
Liu Y,Zhang M,He T,Yang W,Wang L,Zhang L,Guo M
Mon Feb 10 00:00:00 EST 2020
Phenolic Glycosides from the Roots of Ficus hirta Vahl. and Their Antineuroinflammatory Activities.
Journal of agricultural and food chemistry
Ye X,Tian W,Wang G,Zhang X,Zhou M,Zeng D,Liu X,Yao X,Zhang Y,Chen H
Wed Apr 08 00:00:00 EDT 2020
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/β-catenin and AKT pathways.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Feng AL,Han X,Meng X,Chen Z,Li Q,Shu W,Dai H,Zhu J,Yang Z
Thu Oct 01 00:00:00 EDT 2020
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Oxidative medicine and cellular longevity
Meng X,Zhang C,Guo Y,Han Y,Wang C,Chu H,Kong L,Ma H
Thu Feb 04 00:00:00 EST 2021
Inhibition of protein phosphatase methylesterase 1 dysregulates MAP kinase signaling and attenuates muscle cell differentiation.
Gene
Labuzan SA,Lynch SA,Cooper LM,Waddell DS
Wed May 20 00:00:00 EDT 2020
Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling.
Aging
Dai H,Li M,Yang W,Sun X,Wang P,Wang X,Su J,Wang X,Hu X,Zhao M
Fri Jun 12 00:00:00 EDT 2020
Circadian Clock Protein PERIOD2 Suppresses the PI3K/Akt Pathway and Promotes Cisplatin Sensitivity in Ovarian Cancer.
Cancer management and research
Wang Z,Li F,Wei M,Zhang S,Wang T
Mon Apr 18 00:00:00 EDT 2022
Allogeneic adipose-derived stem cells suppress mTORC1 pathway in a murine model of systemic lupus erythematosus.
Lupus
Wei S,Xie S,Yang Z,Peng X,Gong L,Zhao K,Zeng K,Lai K
Fri Feb 01 00:00:00 EST 2019
Allogeneic adipose-derived stem cells suppress mTORC1 pathway in a murine model of systemic lupus erythematosus.
Lupus
Wei S,Xie S,Yang Z,Peng X,Gong L,Zhao K,Zeng K,Lai K
Fri Feb 01 00:00:00 EST 2019
Knockdown of METTL14 inhibits the growth and invasion of cervical cancer.
Translational cancer research
Geng F,Fan MJ,Li J,Liang SM,Li CY,Li N
Tue Oct 01 00:00:00 EDT 2019
Dual-specificity tyrosine phosphorylation-regulated kinase 1A ameliorates insulin resistance in neurons by up-regulating IRS-1 expression.
The Journal of biological chemistry
Tian S,Jia W,Lu M,Zhao J,Sun X
Fri Dec 27 00:00:00 EST 2019
ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways.
Experimental cell research
Wu Y,Tan X,Liu P,Yang Y,Huang Y,Liu X,Meng X,Yu B,Wu M,Jin H
Sat Jun 01 00:00:00 EDT 2019
Combined targeting of PI3K and MEK effector pathways via CED for DIPG therapy.
Neuro-oncology advances
Chang R,Tosi U,Voronina J,Adeuyan O,Wu LY,Schweitzer ME,Pisapia DJ,Becher OJ,Souweidane MM,Maachani UB
Fri Apr 15 00:00:00 EDT 2022
SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.
International journal of medical sciences
Wang Q,Jia S,Jiao Y,Xu L,Wang D,Chen X,Hu X,Liang H,Wen N,Zhang S,Guo B,Zhang L
Thu Apr 30 00:00:00 EDT 2020
Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling.
Evidence-based complementary and alternative medicine : eCAM
Guo Y,Pei X
Sun Apr 10 00:00:00 EDT 2022
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Free radical biology & medicine
Li H,Tang Z,Chu P,Song Y,Yang Y,Sun B,Niu M,Qaed E,Shopit A,Han G,Ma X,Peng J,Hu M,Tang Z
Sun May 20 00:00:00 EDT 2018
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Free radical biology & medicine
Li H,Tang Z,Chu P,Song Y,Yang Y,Sun B,Niu M,Qaed E,Shopit A,Han G,Ma X,Peng J,Hu M,Tang Z
Sun May 20 00:00:00 EDT 2018
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Free radical biology & medicine
Li H,Tang Z,Chu P,Song Y,Yang Y,Sun B,Niu M,Qaed E,Shopit A,Han G,Ma X,Peng J,Hu M,Tang Z
Sun May 20 00:00:00 EDT 2018
Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Gao W,Xiao C,Hu J,Chen B,Wang C,Cui B,Deng P,Yang J,Deng Z
Sun Jul 01 00:00:00 EDT 2018
Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Gao W,Xiao C,Hu J,Chen B,Wang C,Cui B,Deng P,Yang J,Deng Z
Sun Jul 01 00:00:00 EDT 2018
The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells.
Frontiers in endocrinology
Suo L,Chang X,Zhao Y
Wed Nov 20 00:00:00 EST 2019
The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells.
Frontiers in endocrinology
Suo L,Chang X,Zhao Y
Wed Nov 20 00:00:00 EST 2019
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Oncology letters
Zhang H,Cao Y,Chen Y,Li G,Yu H
Sun Apr 01 00:00:00 EDT 2018
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Oncology letters
Zhang H,Cao Y,Chen Y,Li G,Yu H
Sun Apr 01 00:00:00 EDT 2018
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Experimental and therapeutic medicine
Feng J,Niu P,Chen K,Wu L,Liu T,Xu S,Li J,Li S,Wang W,Lu X,Yu Q,Liu N,Xu L,Wang F,Dai W,Xia Y,Fan X,Guo C
Fri Jun 01 00:00:00 EDT 2018
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Experimental and therapeutic medicine
Feng J,Niu P,Chen K,Wu L,Liu T,Xu S,Li J,Li S,Wang W,Lu X,Yu Q,Liu N,Xu L,Wang F,Dai W,Xia Y,Fan X,Guo C
Fri Jun 01 00:00:00 EDT 2018
Apigenin ameliorates vascular injury in rats with high fructose-induced metabolic disturbance by inhibiting PI3K/AKT/GLUT1.
RSC advances
Chen X,Tan J,Zhang L,Liu Y,Cheng Y,Zhang Q,Ding H
Mon Jul 02 00:00:00 EDT 2018
Diosmetin Attenuates Akt Signaling Pathway by Modulating Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB)/Inducible Nitric Oxide Synthase (iNOS) in Streptozotocin (STZ)-Induced Diabetic Nephropathy Mice.
Medical science monitor : international medical journal of experimental and clinical research
Jiang Y,Liu J,Zhou Z,Liu K,Liu C
Tue Oct 02 00:00:00 EDT 2018
Diosmetin Attenuates Akt Signaling Pathway by Modulating Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB)/Inducible Nitric Oxide Synthase (iNOS) in Streptozotocin (STZ)-Induced Diabetic Nephropathy Mice.
Medical science monitor : international medical journal of experimental and clinical research
Jiang Y,Liu J,Zhou Z,Liu K,Liu C
Tue Oct 02 00:00:00 EDT 2018
miR-25 Promotes Melanoma Progression by regulating RNA binding motif protein 47.
Medecine sciences : M/S
Jiang QQ,Liu WB
Mon Oct 01 00:00:00 EDT 2018
Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Li X,Wang G,QiLi M,Liang H,Li T,E X,Feng Y,Zhang Y,Liu X,Qian M,Xu B,Shen Z,Gitau SC,Zhao D,Shan H
Mon May 14 00:00:00 EDT 2018
Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Li X,Wang G,QiLi M,Liang H,Li T,E X,Feng Y,Zhang Y,Liu X,Qian M,Xu B,Shen Z,Gitau SC,Zhao D,Shan H
Mon May 14 00:00:00 EDT 2018
Chiral ruthenium(ii) complex as potent radiosensitizer of 125I through DNA-damage-mediated apoptosis.
RSC advances
Bai M,Zeng Z,Li L,Wu Q,Zhang Y,Pan T,Mu L,Zhu D,Guan S,Xie Q,Mei W
Tue Jun 05 00:00:00 EDT 2018
UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway.
Molecular medicine reports
Shi X,Yang L,Xie J,Zhao Y,Cong J,Li Z,Li H,Cheng X,Fan J
Sat Sep 01 00:00:00 EDT 2018
Angiopoietin-like protein 2 facilitates non-small cell lung cancer progression by promoting the polarization of M2 tumor-associated macrophages.
American journal of cancer research
Wei X,Nie S,Liu H,Sun J,Liu J,Li J,Li S,Wang S,Han S,Wang J,Sun Y
Sat Apr 09 00:00:00 EDT 2022
Angiopoietin-like protein 2 facilitates non-small cell lung cancer progression by promoting the polarization of M2 tumor-associated macrophages.
American journal of cancer research
Wei X,Nie S,Liu H,Sun J,Liu J,Li J,Li S,Wang S,Han S,Wang J,Sun Y
Sat Apr 09 00:00:00 EDT 2022
DHPAC, a novel synthetic microtubule destabilizing agent, possess high anti-tumor activity in vincristine-resistant oral epidermoid carcinoma in vitro and in vivo.
The international journal of biochemistry & cell biology
Zhang Y,Gong FL,Lu ZN,Wang HY,Cheng YN,Liu ZP,Yu LG,Zhang HH,Guo XL
Fri Dec 01 00:00:00 EST 2017
DHPAC, a novel synthetic microtubule destabilizing agent, possess high anti-tumor activity in vincristine-resistant oral epidermoid carcinoma in vitro and in vivo.
The international journal of biochemistry & cell biology
Zhang Y,Gong FL,Lu ZN,Wang HY,Cheng YN,Liu ZP,Yu LG,Zhang HH,Guo XL
Fri Dec 01 00:00:00 EST 2017
Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo.
Journal of molecular endocrinology
Shen CT,Wei WJ,Qiu ZL,Song HJ,Zhang XY,Sun ZK,Luo QY
Sun Jan 01 00:00:00 EST 2017
Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo.
Journal of molecular endocrinology
Shen CT,Wei WJ,Qiu ZL,Song HJ,Zhang XY,Sun ZK,Luo QY
Sun Jan 01 00:00:00 EST 2017
Anti-tumor effect of evodiamine by inducing Akt-mediated apoptosis in hepatocellular carcinoma.
Biochemical and biophysical research communications
Yang F,Shi L,Liang T,Ji L,Zhang G,Shen Y,Zhu F,Xu L
Sat Mar 25 00:00:00 EDT 2017
CALCB splice region pathogenic variants leading to plasma cell neurotropic enrichment in type 1 autoimmune pancreatitis.
Cell death & disease
Liu QC,Chen F,Wu CY,Gao F,Zhuang ZH,Chen JT,Cai B,Zhang T,Guo L,Lin LQ,Zhao CF,Lin XH
Thu Feb 02 00:00:00 EST 2017
CALCB splice region pathogenic variants leading to plasma cell neurotropic enrichment in type 1 autoimmune pancreatitis.
Cell death & disease
Liu QC,Chen F,Wu CY,Gao F,Zhuang ZH,Chen JT,Cai B,Zhang T,Guo L,Lin LQ,Zhao CF,Lin XH
Thu Feb 02 00:00:00 EST 2017
SOCS1 regulates hepatic regenerative response and provides prognostic makers for acute obstructive cholangitis.
Scientific reports
Yu J,Zhang W,Qian H,Tang H,Lin W,Lu B
Fri Aug 25 00:00:00 EDT 2017
SOCS1 regulates hepatic regenerative response and provides prognostic makers for acute obstructive cholangitis.
Scientific reports
Yu J,Zhang W,Qian H,Tang H,Lin W,Lu B
Fri Aug 25 00:00:00 EDT 2017
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Scientific reports
Wu L,Zhang Q,Mo W,Feng J,Li S,Li J,Liu T,Xu S,Wang W,Lu X,Yu Q,Chen K,Xia Y,Lu J,Xu L,Zhou Y,Fan X,Guo C
Thu Aug 24 00:00:00 EDT 2017
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Scientific reports
Wu L,Zhang Q,Mo W,Feng J,Li S,Li J,Liu T,Xu S,Wang W,Lu X,Yu Q,Chen K,Xia Y,Lu J,Xu L,Zhou Y,Fan X,Guo C
Thu Aug 24 00:00:00 EDT 2017
Enho Mutations Causing Low Adropin: A Possible Pathomechanism of MPO-ANCA Associated Lung Injury.
EBioMedicine
Gao F,Fang J,Chen F,Wang C,Chen S,Zhang S,Lv X,Zhang J,He Q,Weng S,Liu Q,Lin XH
Fri Jul 01 00:00:00 EDT 2016
