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ALDH1L2 Polyclonal Antibody

ALDH1L2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 8

ALDH1L2 Antibody (21391-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas slide using 21391-1-AP ( ALDH1L2 Antibody) at dilution of 1:50.

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Product Details

21391-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ALDH1L2 Fusion Protein Ag16046 (1-103 aa encoded by BC103935)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.45 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MVTFYGSTL LNSSVPPGEP LEIKGAKKPG LVTKNGLVLF GNDGKALTVR NLQFEDGKMI PASQYFSTGE TSVVELTAEE VKVAETIKVI WAGILSNVPI IEDS (1-103 aa encoded by BC103935)

Target Information

This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hypermethylation suppresses microRNA-219a-2 to activate the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis.

Research square

Xiao X,Huo E,Guo C,Zhou X,Hu X,Dong C,Shi H,Dong Z,Wei Q

Mon Jun 05 00:00:00 EDT 2023

G6PD-mediated increase in de novo NADP⁺ biosynthesis promotes antioxidant defense and tumor metastasis.

Science advances

Zhang Y,Xu Y,Lu W,Li J,Yu S,Brown EJ,Stanger BZ,Rabinowitz JD,Yang X

Fri Jul 22 00:00:00 EDT 2022

Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.

Molecular cell

Fiore A,Zeitler L,Russier M,Groß A,Hiller MK,Parker JL,Stier L,Köcher T,Newstead S,Murray PJ

Thu Mar 03 00:00:00 EST 2022

Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2.

Free radical biology & medicine

Yang Y,Liu S,Gao H,Wang P,Zhang Y,Zhang A,Jia Z,Huang S

Wed May 20 00:00:00 EDT 2020

Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2.

Free radical biology & medicine

Yang Y,Liu S,Gao H,Wang P,Zhang Y,Zhang A,Jia Z,Huang S

Wed May 20 00:00:00 EDT 2020

Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2.

Free radical biology & medicine

Yang Y,Liu S,Gao H,Wang P,Zhang Y,Zhang A,Jia Z,Huang S

Wed May 20 00:00:00 EDT 2020

Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2.

Free radical biology & medicine

Yang Y,Liu S,Gao H,Wang P,Zhang Y,Zhang A,Jia Z,Huang S

Wed May 20 00:00:00 EDT 2020

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death.

Nature communications

Balsa E,Perry EA,Bennett CF,Jedrychowski M,Gygi SP,Doench JG,Puigserver P

Mon Jun 01 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: 10-formyltetrahydrofolate dehydrogenase ALDH1L2; aldehyde dehydrogenase 1 family, member L2; aldehyde dehydrogenase 1L2; Aldehyde dehydrogenase family 1 member L2; aldehyde dehydrogenase family 1 member L2, mitochondrial; Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Mitochondrial 10-FTHFDH; probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2

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Gene Aliases: ALDH1L2; D330038I09Rik; mtFDH; RGD1309458

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UniProt ID: (Human) Q3SY69, (Mouse) Q8K009

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Entrez Gene ID: (Human) 160428, (Rat) 299699, (Mouse) 216188

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Function(s)

aldehyde dehydrogenase (NAD) activity formyltetrahydrofolate dehydrogenase activity hydroxymethyl-, formyl- and related transferase activity aminobutyraldehyde dehydrogenase activity 4-trimethylammoniobutyraldehyde dehydrogenase activity methyltransferase activity catalytic activity oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor dehydrogenase RNA processing factor oxidoreductase metabolite interconversion enzyme

Process(es)

one-carbon metabolic process biosynthetic process 10-formyltetrahydrofolate catabolic process folic acid metabolic process oxidation-reduction process methylation metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ALDH1L2 Polyclonal Antibody

ALDH1L2 Antibody (21391-1-AP) in IHC (P)

Product Details

21391-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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