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Product Details
TA807013
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI3F1
Immunogen
Human recombinant protein fragment corresponding to amino acids 18-364 of human ALOX5 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a protein which, with Arachidonate 5-lipoxygenase-activating protein, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-LO; Arachidonate 5-lipoxygenase; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; LOX-5; lox5; Polyunsaturated fatty acid 5-lipoxygenase; RP11-67C2.3
Gene Aliases: 5-LO; 5-LOX; 5LPG; ALOX5; LOG5
UniProt ID: (Human) P09917
Entrez Gene ID: (Human) 240
acute inflammatory response
leukotriene production involved in inflammatory response
leukotriene metabolic process
response to nutrient
sensory perception of pain
arachidonic acid metabolic process
leukotriene biosynthetic process
lipoxygenase pathway
positive regulation of vasoconstriction
response to hyperoxia
oxidation-reduction process
lipoxin metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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