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Product Details
H00120425-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AMICA1 (AAI00798.1, 1 a.a. approximately 355 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGCVFQSTED KCIFKIDWTL SPGEHAKDEY VLYYYSNLSV PIGRFQNRVH LMGDILCNDG SLLLQDVQEA DQGTYICEIR LKGESQVFKK AVVLHVLPEE PKELMVHVGG LIQMGCVFQS TEVKHVTKVE WIFSGRRAKE EIVFRYYHKL RMSVEYSQSW GHFQNRVNLV GDIFRNDGSI MLQGVRESDG GNYTCSIHLG NLVFKKTIVL HVSPEEPRTL VTPAALRPLV LGGNQLVIIV GIVCATILLL PVLILIVKKT CGNKSSVNST VLVKNTKKTN PEIKEKPCHF ERCEGEKHIY SPIIVREVIE EEEPSEKSEA TYMTMHPVWP SLRSDRNNSL EKKSGGGMPK TQQAF
Target Information
AMICA transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adhesion molecule AMICA; Adhesion molecule interacting with CXADR antigen 1; adhesion molecule, interacts with CXADR antigen 1; Dendritic cell-specific protein CREA7-1; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; Junctional adhesion molecule-like
Gene Aliases: AMICA; AMICA1; CREA7-1; CREA7-4; Gm638; JAML; UNQ722/PRO1387
UniProt ID: (Human) Q86YT9
Entrez Gene ID: (Human) 120425
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
neutrophil chemotaxis
monocyte extravasation
gamma-delta T cell activation
regulation of immune response
leukocyte migration
positive regulation of epithelial cell proliferation involved in wound healing
neutrophil extravasation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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