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Alomone Labs, LTD
p75 NGF Receptor (extracellular) Monoclonal Antibody (192-IgG), FITC
Product Details
AN-170-F-50UG
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
192-IgG
Immunogen
Solubilized proteins from PC12 membranes., Solubilized proteins from PC12 membranes.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µg double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD271; CD271 antigen; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor, fast; NGF receptor; p-75; p75 ICD; p75 ntr; TNR16; Tumor necrosis factor receptor superfamily member 16
Gene Aliases: LNGFR; Ngfr; p75; p75NTR; RNNGFRR; Tnfrsf16
UniProt ID: (Rat) P07174
Entrez Gene ID: (Rat) 24596
intracellular protein transport
apoptotic process
signal transduction
axon guidance
central nervous system development
response to wounding
regulation of gene expression
positive regulation of cell death
negative regulation of neuron projection development
programmed cell death
detection of temperature stimulus
sensory perception of pain
nerve development
hair follicle morphogenesis
positive regulation of myelination
positive regulation of synaptic transmission, cholinergic
response to lipopolysaccharide
circadian regulation of gene expression
cellular response to oxidative stress
positive regulation of Rho protein signal transduction
skeletal muscle cell differentiation
negative regulation of fibroblast growth factor receptor signaling pathway
positive regulation of odontogenesis of dentin-containing tooth
glucose homeostasis
positive regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
skin development
positive regulation of fibroblast proliferation
negative regulation of hair follicle development
positive regulation of protein kinase B signaling
negative regulation of mitochondrial depolarization
positive regulation of synaptic transmission, glutamatergic
negative regulation of cell death
positive regulation of neuron death
regulation of reactive oxygen species metabolic process
positive regulation of apoptotic signaling pathway
regulation of glucose import in response to insulin stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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