Proteintech

ANGPTL4 Polyclonal Antibody

ANGPTL4 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 14

ANGPTL4 Antibody (18374-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed NIH/3T3 cells using 18374-1-AP (ANGPTL4 antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

ANGPTL4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ANGPTL4 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

18374-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ANGPTL4 Fusion Protein Ag13237 (1-374 aa encoded by BC023647)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSGAPTAGA ALMLCAATAV LLSAQGGPVQ SKSPRFASWD EMNVLAHGLL QLGQGLREHA ERTRSQLSAL ERRLSACGSA CQGTEGSTDL PLAPESRVDP EVLHSLQTQL KAQNSRIQQL FHKVAQQQRH LEKQHLRIQH LQSQFGLLDH KHLDHEVAKP ARRKRLPEMA QPVDPAHNVS RLHRLPRDCQ ELFQVGERQS GLFEIQPQGS PPFLVNCKMT SDGGWTVIQR RHDGSVDFNR PWEAYKAGFG DPHGEFWLGL EKVHSITGDR NSRLAVQLRD WDGNAELLQF SVHLGGEDTA YSLQLTAPVA GQLGATTVPP SGLSVPFSTW DQDHDLRRDK NCAKSLSGGW WFGTCSHSNL NGQYFRSIPQ QRQKL (1-374 aa encoded by BC023647)

Target Information

Angiopoietin-like protein 4 (ANGPTL4), is a secreted protein selectively expressed in adipose tissue, liver, and placenta1-3 that plays a variety of roles in vivo, ranging from adipogenesis to angiogenesis to carcinogenesis. The expression of ANGPTL4 is also under nutritional and hormonal control. ANGPTL4 has been observed to induce a strong pro-angiogenic response independent of vascular endothelial growth factor (VEGF), and its expression has been described in hypoxic human tissues as well as a variety of cancers, including liposarcoma, hepatocellular carcinoma, and conventional renal cell carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

High glucose-induced IL-7/IL-7R upregulation of dermal fibroblasts inhibits angiogenesis in a paracrine way in delayed diabetic wound healing.

Journal of cell communication and signaling

Gao R,Zhou P,Li Y,Li Q

Fri Sep 01 00:00:00 EDT 2023

N-acetylglucosamine-bearing polymers mimicking O-GlcNAc-modified proteins elicit anti-fibrotic activities in myofibroblasts and activated stellate cells.

Glycobiology

Ise H,Araki Y,Song I,Akatsuka G

Sun Jan 08 00:00:00 EST 2023

N-acetylglucosamine-bearing polymers mimicking O-GlcNAc-modified proteins elicit anti-fibrotic activities in myofibroblasts and activated stellate cells.

Glycobiology

Ise H,Araki Y,Song I,Akatsuka G

Sun Jan 08 00:00:00 EST 2023

N-acetylglucosamine-bearing polymers mimicking O-GlcNAc-modified proteins elicit anti-fibrotic activities in myofibroblasts and activated stellate cells.

Glycobiology

Ise H,Araki Y,Song I,Akatsuka G

Sun Jan 08 00:00:00 EST 2023

N-acetylglucosamine-bearing polymers mimicking O-GlcNAc-modified proteins elicit anti-fibrotic activities in myofibroblasts and activated stellate cells.

Glycobiology

Ise H,Araki Y,Song I,Akatsuka G

Sun Jan 08 00:00:00 EST 2023

Angiopoietin-like 4 induces head and neck squamous cell carcinoma cell migration through the NRP1/ABL1/PXN pathway.

Cellular signalling

Hefni E,Menon D,Ma T,Asiedu EB,Sultan A,Meiller T,Schneider A,Sodhi A,Montaner S

Tue Aug 01 00:00:00 EDT 2023

Angiopoietin-like 4 induces head and neck squamous cell carcinoma cell migration through the NRP1/ABL1/PXN pathway.

Cellular signalling

Hefni E,Menon D,Ma T,Asiedu EB,Sultan A,Meiller T,Schneider A,Sodhi A,Montaner S

Tue Aug 01 00:00:00 EDT 2023

Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.

Oncology reports

Cai Z,Li Y,Ma M,Wang L,Wang H,Liu M,Jiang C

Sat Jul 01 00:00:00 EDT 2023

Angiopoietin-like 4 Is a Critical Regulator of Fibroblasts during Pulmonary Fibrosis Development.

American journal of respiratory cell and molecular biology

Saito S,Kitabatake M,Ouji-Sageshima N,Ogawa T,Oda A,Nishimura T,Nishioka T,Fushimi S,Hara A,Shichino S,Kumamoto M,Hontsu S,Kawaguchi T,Ueha S,Sawabata N,Muro S,Matsushima K,Ito T

Fri Sep 01 00:00:00 EDT 2023

Integrative Proteomic and Phosphoproteomic Analyses of Hypoxia-Treated Pulmonary Artery Smooth Muscle Cells.

Proteomes

Luo A,Hao R,Zhou X,Jia Y,Tang H

Tue Jun 28 00:00:00 EDT 2022

Angiopoietin-like 4 promotes glucose metabolism by regulating glucose transporter expression in colorectal cancer.

Journal of cancer research and clinical oncology

Mizuno S,Seishima R,Yamasaki J,Hattori K,Ogiri M,Matsui S,Shigeta K,Okabayashi K,Nagano O,Li L,Kitagawa Y

Wed Jun 01 00:00:00 EDT 2022

Angiopoietin-like 4 promotes glucose metabolism by regulating glucose transporter expression in colorectal cancer.

Journal of cancer research and clinical oncology

Mizuno S,Seishima R,Yamasaki J,Hattori K,Ogiri M,Matsui S,Shigeta K,Okabayashi K,Nagano O,Li L,Kitagawa Y

Wed Jun 01 00:00:00 EDT 2022

Angiopoietin-like 4 promotes glucose metabolism by regulating glucose transporter expression in colorectal cancer.

Journal of cancer research and clinical oncology

Mizuno S,Seishima R,Yamasaki J,Hattori K,Ogiri M,Matsui S,Shigeta K,Okabayashi K,Nagano O,Li L,Kitagawa Y

Wed Jun 01 00:00:00 EDT 2022

Angiopoietin-like 4 promotes glucose metabolism by regulating glucose transporter expression in colorectal cancer.

Journal of cancer research and clinical oncology

Mizuno S,Seishima R,Yamasaki J,Hattori K,Ogiri M,Matsui S,Shigeta K,Okabayashi K,Nagano O,Li L,Kitagawa Y

Wed Jun 01 00:00:00 EDT 2022

ANGPTL4 regulates the osteogenic differentiation of periodontal ligament stem cells.

Functional & integrative genomics

Xu L,Wang C,Li Y,Wang Y,Fu B,Yang G

Sat Oct 01 00:00:00 EDT 2022

ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model.

International immunopharmacology

Gao Y,Ma Y,Xie D,Jiang H

Wed Jun 01 00:00:00 EDT 2022

ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model.

International immunopharmacology

Gao Y,Ma Y,Xie D,Jiang H

Wed Jun 01 00:00:00 EDT 2022

Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.

Journal of agricultural and food chemistry

Xing Y,Ren X,Li X,Sui L,Shi X,Sun Y,Quan C,Xiu Z,Dong Y

Wed Sep 01 00:00:00 EDT 2021

Banxia Baizhu Tianma decoction attenuates obesity-related hypertension.

Journal of ethnopharmacology

Jiang YH,Zhang P,Tao Y,Liu Y,Cao G,Zhou L,Yang CH

Wed Feb 10 00:00:00 EST 2021

Expression of ANGPTL4 in Nucleus Pulposus Tissues Is Associated with Intervertebral Disc Degeneration.

Disease markers

Liu FJ,Xie LY,Li HZ,Cao SN,Chen YZ,Wang DD

Thu Mar 17 00:00:00 EDT 2022

Allobaculum Involves in the Modulation of Intestinal ANGPTLT4 Expression in Mice Treated by High-Fat Diet.

Frontiers in nutrition

Zheng Z,Lyu W,Ren Y,Li X,Zhao S,Yang H,Xiao Y

Tue Jun 08 00:00:00 EDT 2021

Decreased ANGPTL4 impairs endometrial angiogenesis during peri-implantation period in patients with recurrent implantation failure.

Journal of cellular and molecular medicine

Li M,Hu J,Yao L,Gao M

Tue Sep 01 00:00:00 EDT 2020

Decreased ANGPTL4 impairs endometrial angiogenesis during peri-implantation period in patients with recurrent implantation failure.

Journal of cellular and molecular medicine

Li M,Hu J,Yao L,Gao M

Tue Sep 01 00:00:00 EDT 2020

LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling.

The EMBO journal

Wang Y,Zhu P,Luo J,Wang J,Liu Z,Wu W,Du Y,Ye B,Wang D,He L,Ren W,Wang J,Sun X,Chen R,Tian Y,Fan Z

Mon Sep 02 00:00:00 EDT 2019

Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edema.

The Journal of clinical investigation

Sodhi A,Ma T,Menon D,Deshpande M,Jee K,Dinabandhu A,Vancel J,Lu D,Montaner S

Fri Nov 01 00:00:00 EDT 2019

Angiopoietin-Like Protein 4 (ANGPTL4) Induces Retinal Pigment Epithelial Barrier Breakdown by Activating Signal Transducer and Activator of Transcription 3 (STAT3): Evidence from ARPE-19 Cells Under Hypoxic Condition and Diabetic Rats.

Medical science monitor : international medical journal of experimental and clinical research

Yang X,Cao J,Du Y,Gong Q,Cheng Y,Su G

Sun Sep 08 00:00:00 EDT 2019

The long non-coding RNA PVT1 represses ANGPTL4 transcription through binding with EZH2 in trophoblast cell.

Journal of cellular and molecular medicine

Xu Y,Lian Y,Zhang Y,Huang S,Zuo Q,Yang N,Chen Y,Wu D,Sun L

Thu Feb 01 00:00:00 EST 2018

The long non-coding RNA PVT1 represses ANGPTL4 transcription through binding with EZH2 in trophoblast cell.

Journal of cellular and molecular medicine

Xu Y,Lian Y,Zhang Y,Huang S,Zuo Q,Yang N,Chen Y,Wu D,Sun L

Thu Feb 01 00:00:00 EST 2018

The long non-coding RNA PVT1 represses ANGPTL4 transcription through binding with EZH2 in trophoblast cell.

Journal of cellular and molecular medicine

Xu Y,Lian Y,Zhang Y,Huang S,Zuo Q,Yang N,Chen Y,Wu D,Sun L

Thu Feb 01 00:00:00 EST 2018

The long non-coding RNA PVT1 represses ANGPTL4 transcription through binding with EZH2 in trophoblast cell.

Journal of cellular and molecular medicine

Xu Y,Lian Y,Zhang Y,Huang S,Zuo Q,Yang N,Chen Y,Wu D,Sun L

Thu Feb 01 00:00:00 EST 2018

Hypoxia-induced angiopoietin-like protein 4 as a clinical biomarker and treatment target for human prostate cancer.

Oncology reports

Hata S,Nomura T,Iwasaki K,Sato R,Yamasaki M,Sato F,Mimata H

Sat Jul 01 00:00:00 EDT 2017

Hypoxia-induced angiopoietin-like protein 4 as a clinical biomarker and treatment target for human prostate cancer.

Oncology reports

Hata S,Nomura T,Iwasaki K,Sato R,Yamasaki M,Sato F,Mimata H

Sat Jul 01 00:00:00 EDT 2017

ANGPTL4 promotes the progression of cutaneous melanoma to brain metastasis.

Oncotarget

Izraely S,Ben-Menachem S,Sagi-Assif O,Meshel T,Marzese DM,Ohe S,Zubrilov I,Pasmanik-Chor M,Hoon DSB,Witz IP

Fri Sep 29 00:00:00 EDT 2017

ANGPTL4-αvβ3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2.

The Journal of pathology

Gomez Perdiguero E,Liabotis-Fontugne A,Durand M,Faye C,Ricard-Blum S,Simonutti M,Augustin S,Robb BM,Paques M,Valenzuela DM,Murphy AJ,Yancopoulos GD,Thurston G,Galaup A,Monnot C,Germain S

Thu Dec 01 00:00:00 EST 2016

ANGPTL4-αvβ3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2.

The Journal of pathology

Gomez Perdiguero E,Liabotis-Fontugne A,Durand M,Faye C,Ricard-Blum S,Simonutti M,Augustin S,Robb BM,Paques M,Valenzuela DM,Murphy AJ,Yancopoulos GD,Thurston G,Galaup A,Monnot C,Germain S

Thu Dec 01 00:00:00 EST 2016

An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancer.

Breast cancer research : BCR

Sato M,Kadota M,Tang B,Yang HH,Yang YA,Shan M,Weng J,Welsh MA,Flanders KC,Nagano Y,Michalowski AM,Clifford RJ,Lee MP,Wakefield LM

Mon Jun 02 00:00:00 EDT 2014

An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancer.

Breast cancer research : BCR

Sato M,Kadota M,Tang B,Yang HH,Yang YA,Shan M,Weng J,Welsh MA,Flanders KC,Nagano Y,Michalowski AM,Clifford RJ,Lee MP,Wakefield LM

Mon Jun 02 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: 425O18-1; angiopoietin-like 4; Angiopoietin-like protein 4; Angiopoietin-related protein 4; ANGPTL2; Fasting-i; Fasting-induced adipose factor; fibrinogen/angiopoietin-related protein; hepatic angiopoietin-related protein; Hepatic fibrinogen/angiopoietin-related protein; HFARP; major histocompatibility complex region NG27; peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein; PPARG angiopoietin related protein; Secreted protein Bk89

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Gene Aliases: ANGPTL4; ARP4; Bk89; Farp; FIAF; HARP; HFARP; Ng27; NL2; PGAR; Pgarg; PP1158; PSEC0166; TGQTL; UNQ171; UNQ171/PRO197

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UniProt ID: (Human) Q9BY76, (Mouse) Q9Z1P8

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Entrez Gene ID: (Human) 51129, (Mouse) 57875

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Function(s)

enzyme inhibitor activity protein binding identical protein binding intercellular signal molecule

Process(es)

angiogenesis response to hypoxia cell differentiation negative regulation of apoptotic process positive regulation of angiogenesis negative regulation of lipoprotein lipase activity protein homooligomerization triglyceride homeostasis negative regulation of endothelial cell apoptotic process cellular response to starvation positive regulation of lipid metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ANGPTL4 Polyclonal Antibody

ANGPTL4 Antibody (18374-1-AP) in ICC/IF

Product Details

18374-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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