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Product Details
27766-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ANK3 Fusion Protein Ag26948 (3668-3870 aa encoded by NM_001149)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: METNLERNV ETPTVEPNPS IPTSGECQEG TSSSGSLEKS AAATNTSKVD PKLRTPIKMG ISASTMTMKK EGPGEITDKI EAVMTSCQGL ENETITMISN TANSQMGVRP HEKHDFQKDN FNNNNNLDSS TIQTDNIMSN IVLTEHSAPT CTTEKDNPVK VSSGKKTGVL QGHCVRDKQK VLGEQQKTKE LIGIRQKSKL PIKAT (3668-3870 aa encoded by NM_001149)
Target Information
Ankyrin-G is found in several tissues including brain where, due to tissue-specific RNA processing, it is expressed as two different isoforms, localized to axon initial segments and nodes of Ranvier. Ankyrin-G is also found at sites of epithelial cell-cell contact and in the intracellular membranes of some cells. Ankyrin-G isoforms contain a unique stretch of sequence highly enriched in serine and threonine residues immediately following a globular head domain. Ankyrin-G is thought to participate in the maintenance and targeting of ion channels and cell adhesion molecules to the nodes of Ranvier and to axon initial segments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANK-3; Ankyrin-3; Ankyrin-G; brain-specific ankyrin-G
Gene Aliases: 2900054D09Rik; AI314020; Ank-3; ANK3; AnkG; Ankyrin-3; ANKYRIN-G; MRT37
UniProt ID: (Human) Q12955, (Mouse) G5E8K5
Entrez Gene ID: (Human) 288, (Mouse) 11735
mitotic cytokinesis
ER to Golgi vesicle-mediated transport
plasma membrane organization
cytoskeletal anchoring at plasma membrane
signal transduction
axonogenesis
axon guidance
neuromuscular junction development
positive regulation of gene expression
positive regulation of cell communication by electrical coupling
positive regulation of sodium ion transport
magnesium ion homeostasis
neuronal action potential
positive regulation of homotypic cell-cell adhesion
Golgi to plasma membrane protein transport
regulation of potassium ion transport
establishment of protein localization
positive regulation of membrane potential
cellular response to magnesium ion
membrane assembly
protein localization to plasma membrane
maintenance of protein location in plasma membrane
protein targeting to plasma membrane
positive regulation of protein targeting to membrane
positive regulation of membrane depolarization during cardiac muscle cell action potential
negative regulation of delayed rectifier potassium channel activity
positive regulation of sodium ion transmembrane transporter activity
positive regulation of cation channel activity
positive regulation of action potential
synapse organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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