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Product Details
15997-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ANT1/2 Fusion Protein Ag7787 (1-298 aa encoded by BC008664)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes both of ANT1 and ANT2.
Immunogen sequence: MGDHAWSFL KDFLAGGVAA AVSKTAVAPI ERVKLLLQVQ HASKQISAEK QYKGIIDCVV RIPKEQGFLS FWRGNLANVI RYFPTQALNF AFKDKYKQLF LGGVDRHKQF WRYFAGNLAS GGAAGATSLC FVYPLDFART RLAADVGKGA AQREFHGLGD CIIKIFKSDG LRGLYQGFNV SVQGIIIYRA AYFGVYDTAK GMLPDPKNVH IFVSWMIAQS VTAVAGLVSY PFDTVRRRMM MQSGRKGADI MYTGTVDCWR KIAKDEGAKA FFKGAWSNVL RGMGGAFVLV LYDEIKKYV (1-298 aa encoded by BC008664 )
Target Information
Adenine nucleotide translocator (ANT) and the voltage-dependent anion-selective channel proteins 1 and 2 (VDAC1 and VDAC2) are components of the permeability transition pore complex (PTPC) of the mitochondrial inner and outer membranes, respectively. Formation of PTPCs, the subsequent dissipation of mitochondrial inner membrane potential and release of cytochrome c through the outer mitochondrial membrane are critical events in the early stages of apoptosis. Bax, a proapoptotic protein, has been shown to act upon ANT to induce the dissipation of mitochondrial inner membrane potential. ANT1 has a role in the maintenance of mitochondrial DNA by catalyzing the exchange of ADP and ATP across the mitochondrial inner membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Adenine nucleotid translocator 2 fibroblast isoform (ATP-ADP carrier protein); Adenine nucleotid translocator 2, fibroblast isoform (ATP-ADP carrier protein); adenine nucleotide translocase-1; Adenine nucleotide translocator 1; adenine nucleotide translocator 1 (skeletal muscle); adenine nucleotide translocator 1, skeletal muscle; Adenine nucleotide translocator 2; adenine nucleotide translocator 2 (fibroblast); adenine nucleotide translocator 2 fibroblast isoform (ATP-ADP carrier protein); adenine nucleotide translocator 2, fibroblast isoform (ATP-ADP carrier protein); ADP,ATP carrier protein 1; ADP,ATP carrier protein 2; ADP,ATP carrier protein, fibroblast isoform; ADP,ATP carrier protein, heart/skeletal muscle; ADP,ATP carrier protein, heart/skeletal muscle isoform T1; ADP/ATP translocase 1; ADP/ATP translocase 2; ANT 1; ANT 2; heart/skeletal muscle ATP/ADP translocator; mANC1; mitochondrial adenine nucleotide translocator; solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; Solute carrier family 25 member 4; Solute carrier family 25 member 5
Gene Aliases: 2F1; AAC1; AAC2; Anc1; ANT; ANT 1; ANT1; ANT2; AU019225; MTDPS12; PEO2; PEO3; PEOA2; SLC25A4; SLC25A5; T1; T2; T3
UniProt ID: (Human) P12235, (Human) P05141, (Rat) Q05962, (Mouse) P48962, (Rat) Q09073, (Mouse) P51881
Entrez Gene ID: (Human) 291, (Human) 292, (Rat) 85333, (Mouse) 11739, (Rat) 25176, (Mouse) 11740
mitochondrial genome maintenance
generation of precursor metabolites and energy
translation
transport
apoptotic mitochondrial changes
adenine transport
viral process
regulation of insulin secretion
transmembrane transport
negative regulation of necroptotic process
chromosome segregation
positive regulation of cell proliferation
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
liver development
heart development
aging
negative regulation of cardiac muscle cell apoptotic process
positive regulation of cell growth involved in cardiac muscle cell development
response to interleukin-1
negative regulation of mitochondrial membrane permeability involved in apoptotic process
positive regulation of oxidative phosphorylation uncoupler activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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