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Product Details
BS-0058R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Apaf-1, amino acids 1201-1248.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
APAF1 gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APAF-1; apoptotic protease activating factor 1; Apoptotic protease-activating factor 1; DKFZp781B1145; forebrain overgrowth
Gene Aliases: 6230400I06Rik; APAF-1; APAF1; Apaf1l; CED4; fog; KIAA0413; mKIAA0413; zgc:136543
UniProt ID: (Human) O14727, (Rat) Q9EPV5, (Mouse) O88879, (Zebrafish) Q9I9H8
Entrez Gene ID: (Human) 317, (Rat) 78963, (Mouse) 11783, (Zebrafish) 58131
proteolysis
apoptotic process
regulation of apoptotic process
apoptotic signaling pathway
response to hypoxia
neural tube closure
activation of cysteine-type endopeptidase activity involved in apoptotic process
multicellular organism development
brain development
aging
response to nutrient
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
cardiac muscle cell apoptotic process
cell differentiation
forebrain development
glial cell apoptotic process
protein homooligomerization
neuron apoptotic process
cellular response to transforming growth factor beta stimulus
regulation of apoptotic DNA fragmentation
positive regulation of apoptotic signaling pathway
nervous system development
positive regulation of apoptotic process
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
response to G1 DNA damage checkpoint signaling
intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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