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Product Details
A300-980A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 75 and 125 of human adenomatosis polyposis coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adenomatosis polyposis coli tumor suppressor; Adenomatous polyposis coli protein; Deleted in polyposis 2.5; FPC; Protein APC; protein phosphatase 1, regulatory subunit 46; truncated adenomatosis polyposis coli; WNT signaling pathway regulator
Gene Aliases: APC; BTPS2; DP2; DP2.5; DP3; GS; PPP1R46
UniProt ID: (Human) P25054
Entrez Gene ID: (Human) 324
mitotic cytokinesis
cell fate specification
protein complex assembly
cellular component disassembly involved in execution phase of apoptosis
cellular response to DNA damage stimulus
negative regulation of microtubule depolymerization
cell cycle arrest
mitotic spindle assembly checkpoint
cell adhesion
establishment or maintenance of cell polarity
pattern specification process
negative regulation of cell proliferation
Wnt signaling pathway
cell migration
positive regulation of cell migration
pancreas development
neuron projection development
positive regulation of pseudopodium assembly
regulation of microtubule-based process
response to drug
positive regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of cell differentiation
positive regulation of protein catabolic process
negative regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of attachment of spindle microtubules to kinetochore
canonical Wnt signaling pathway
bicellular tight junction assembly
negative regulation of canonical Wnt signaling pathway
response to alcohol
beta-catenin destruction complex assembly
beta-catenin destruction complex disassembly
cellular response to nerve growth factor stimulus
regulation of glutamate metabolic process
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