Proteintech

APOA4 Polyclonal Antibody

APOA4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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APOA4 Antibody (17996-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver using 17996-1-AP (APOA4 antibody) at dilution of 1:100 (under 40x lens).

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Product Details

17996-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:16,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

APOA4 Fusion Protein Ag12454 (23-396 aa encoded by BC074764)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SADQVATVM WDYFSQLSNN AKEAVEHLQK SELTQQLNAL FQDKLGEVNT YAGDLQKKLV PFATELHERL AKDSEKLKEE IGKELEELRA RLLPHANEVS QKIGDNLREL QQRLEPYADQ LRTQVNTQAE QLRRQLTPYA QRMERVLREN ADSLQASLRP HADELKAKID QNVEELKGRL TPYADEFKVK IDQTVEELRR SLAPYAQDTQ EKLNHQLEGL TFQMKKNAEE LKARISASAE ELRQRLAPLA EDVRGNLRGN TEGLQKSLAE LGGHLDQQVE EFRRRVEPYG ENFNKALVQQ MEQLRQKLGP HAGDVEGHLS FLEKDLRDKV NSFFSTFKEK ESQDKTLSLP ELEQQQEQQQ EQQQEQVQML APLES (23-396 aa encoded by B C074764)

Target Information

Apolipoprotein A4 (also known as ApoA-IV) is a plasma protein that is an O-linked glycoprotein after proteolytic processing. ApoA4 is a major constituent of HDL and it also can be found on the surface of newly synthesized chylomicrons. The physiological function of ApoA4 is not completely identified so far, but evidence from several in vitro studies indicate that this apolipoprotein is involved in several steps of the reverse cholesterol transport pathway, which transports cholesterol from peripheral cells back to the liver.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Binding of serum-derived amyloid-associated proteins to amyloid fibrils.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

Misumi Y,Tabata Y,Tasaki M,Obayashi K,Yamakawa S,Nomura T,Ueda M

Wed Mar 01 00:00:00 EST 2023

The distinct metabolism between large and small HDL indicates unique origins of human apolipoprotein A4.

JCI insight

Andraski AB,Singh SA,Higashi H,Lee LH,Aikawa M,Sacks FM

Mon Apr 24 00:00:00 EDT 2023

HDL Isolated by Immunoaffinity, Ultracentrifugation, or Precipitation is Compositionally and Functionally Distinct.

Journal of lipid research

Holzer M,Ljubojevic-Holzer S,Souza Junior DR,Stadler JT,Rani A,Scharnagl H,Ronsein GE,Marsche G

Thu Dec 01 00:00:00 EST 2022

Protein Panel of Serum-Derived Small Extracellular Vesicles for the Screening and Diagnosis of Epithelial Ovarian Cancer.

Cancers

Lai H,Guo Y,Tian L,Wu L,Li X,Yang Z,Chen S,Ren Y,He S,He W,Yang G

Sat Jul 30 00:00:00 EDT 2022

Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.

Alcohol (Fayetteville, N.Y.)

Chen M,Sun X,Wei W,Cucarella C,Martín-Sanz P,Casado M,Pi L,Ren B,Cao Q

Sat May 01 00:00:00 EDT 2021

Serum APOA4 Pharmacodynamically Represents Administered Recombinant Human Hepatocyte Growth Factor (E3112).

International journal of molecular sciences

Motoi S,Uesugi M,Obara T,Moriya K,Arita Y,Ogasawara H,Soejima M,Imai T,Kawano T

Tue Apr 27 00:00:00 EDT 2021

Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine.

The Journal of experimental medicine

Wang Y,Song W,Wang J,Wang T,Xiong X,Qi Z,Fu W,Yang X,Chen YG

Mon Feb 03 00:00:00 EST 2020

Identification and characterization of proteins that are differentially expressed in adipose tissue of olanzapine-induced insulin resistance rat by iTRAQ quantitative proteomics.

Journal of proteomics

Yang N,Yu L,Deng Y,Han Q,Wang J,Yu L,Zhai Z,Li W

Mon Feb 10 00:00:00 EST 2020

Differential protein analysis of serum exosomes post-intravenous immunoglobulin therapy in patients with Kawasaki disease.

Cardiology in the young

Zhang L,Song QF,Jin JJ,Huang P,Wang ZP,Xie XF,Gu XQ,Gao XJ,Jia HL

Wed Nov 01 00:00:00 EDT 2017

Differential protein analysis of serum exosomes post-intravenous immunoglobulin therapy in patients with Kawasaki disease.

Cardiology in the young

Zhang L,Song QF,Jin JJ,Huang P,Wang ZP,Xie XF,Gu XQ,Gao XJ,Jia HL

Wed Nov 01 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: Apo-AIV; apoA-IV; Apolipoprotein A-IV; Apolipoprotein A4; MGC142154; MGC142156

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Gene Aliases: Apo-AIV; Apoa-4; ApoA-IV; APOA4; apoAIV

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UniProt ID: (Human) P06727, (Mouse) P06728, (Rat) P02651

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Entrez Gene ID: (Human) 337, (Mouse) 11808, (Rat) 25080

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Function(s)

lipid transporter activity copper ion binding protein binding lipid binding cholesterol binding antioxidant activity cholesterol transporter activity phosphatidylcholine binding protein homodimerization activity phosphatidylcholine-sterol O-acyltransferase activator activity apolipoprotein

Process(es)

retinoid metabolic process innate immune response in mucosa cholesterol biosynthetic process lipid transport response to lipid hydroperoxide leukocyte cell-cell adhesion cholesterol metabolic process positive regulation of cholesterol esterification positive regulation of triglyceride catabolic process removal of superoxide radicals regulation of intestinal cholesterol absorption neuron projection regeneration regulation of cholesterol transport cholesterol efflux phospholipid efflux chylomicron remodeling very-low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling chylomicron assembly high-density lipoprotein particle assembly negative regulation of plasma lipoprotein particle oxidation response to stilbenoid lipoprotein metabolic process lipoprotein biosynthetic process cholesterol homeostasis hydrogen peroxide catabolic process reverse cholesterol transport multicellular organism lipid catabolic process cellular protein metabolic process positive regulation of fatty acid biosynthetic process phosphatidylcholine metabolic process positive regulation of lipoprotein lipase activity lipid homeostasis protein-lipid complex assembly triglyceride homeostasis transport triglyceride catabolic process peripheral nervous system axon regeneration response to food response to triglyceride

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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APOA4 Polyclonal Antibody

APOA4 Antibody (17996-1-AP) in IHC (P)

Product Details

17996-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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