Invitrogen

APOE Polyclonal Antibody

View all (57) APOE antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-78803

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived mouse Apolipoprotein E recombinant protein (Position: D55-Q294).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2745919

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Apo E (Apolipoprotein E) plays an important role in the metabolism of lipids in the plasma, and is also is a constituent of various plasma lipoprotein-lipid particles. The protein is synthesized in liver, brain, spleen, and the kidney, and concentrations are high in interstitial fluids, where it plays a role in distributing cholesterol from cells where cholesterol is in excess to cells which require cholesterol. Apo E also plays an important role in the formation of very low density lipoprotein and chylomicrons. The Apo E gene is located on chromosome 19 at position 19q13. 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Apo-E; ApoE4; Apolipoprotein; Apolipoprotein E; apolipoprotein E4; Apoprotein; B2G1; BG; MGC1571

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Gene Aliases: AI255918; Apo-E; Apoe; APOEA

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UniProt ID: (Mouse) P08226, (Rat) P02650

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Entrez Gene ID: (Mouse) 11816, (Rat) 25728

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Function(s)
beta-amyloid binding receptor binding lipid transporter activity phospholipid binding heparin binding lipid binding cholesterol binding antioxidant activity cholesterol transporter activity identical protein binding protein homodimerization activity hydroxyapatite binding metal chelating activity tau protein binding low-density lipoprotein particle receptor binding phosphatidylcholine-sterol O-acyltransferase activator activity very-low-density lipoprotein particle receptor binding lipoprotein particle binding apolipoprotein
Process(es)
negative regulation of endothelial cell proliferation response to dietary excess lipid metabolic process triglyceride metabolic process cholesterol biosynthetic process cholesterol catabolic process lipid transport cellular calcium ion homeostasis receptor-mediated endocytosis response to oxidative stress G-protein coupled receptor signaling pathway nitric oxide mediated signal transduction aging protein localization cholesterol metabolic process regulation of gene expression negative regulation of platelet activation positive regulation of cholesterol esterification positive regulation of cholesterol efflux peripheral nervous system axon regeneration long-chain fatty acid transport protein import triglyceride catabolic process cGMP-mediated signaling negative regulation of blood coagulation positive regulation of cGMP biosynthetic process neuron projection regeneration axon regeneration regulation of cholesterol transport regulation of Cdc42 protein signal transduction response to retinoic acid positive regulation of low-density lipoprotein particle receptor catabolic process response to insulin cholesterol efflux phospholipid efflux very-low-density lipoprotein particle remodeling low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling high-density lipoprotein particle assembly chylomicron remnant clearance high-density lipoprotein particle clearance very-low-density lipoprotein particle clearance lipoprotein metabolic process lipoprotein biosynthetic process lipoprotein catabolic process vasodilation cholesterol homeostasis positive regulation of catalytic activity negative regulation of MAP kinase activity negative regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration reverse cholesterol transport response to ethanol negative regulation of cholesterol biosynthetic process positive regulation of axon extension positive regulation of lipid biosynthetic process oligodendrocyte differentiation artery morphogenesis negative regulation of inflammatory response positive regulation of nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis negative regulation of lipid biosynthetic process maintenance of location in cell lipid homeostasis fatty acid homeostasis positive regulation of dendritic spine development negative regulation of dendritic spine development cellular response to interleukin-1 cellular response to growth factor stimulus cellular response to cholesterol cardiovascular system development negative regulation of cholesterol efflux AMPA glutamate receptor clustering NMDA glutamate receptor clustering regulation of beta-amyloid clearance regulation of neuron death negative regulation of neuron death positive regulation of neuron death negative regulation of postsynaptic membrane organization positive regulation of postsynaptic membrane organization negative regulation of presynaptic membrane organization positive regulation of presynaptic membrane organization positive regulation of beta-amyloid formation negative regulation of beta-amyloid formation regulation of tau-protein kinase activity negative regulation of dendritic spine maintenance positive regulation of dendritic spine maintenance positive regulation of phospholipid efflux positive regulation of neurofibrillary tangle assembly negative regulation of phospholipid efflux negative regulation of lipid transport across blood brain barrier positive regulation of lipid transport across blood brain barrier
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