Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 1
Immunogen sequence: SVDEEELRKQ REEITAIVKM RVAGTASGTQ HAGDFICTVY LEEKKAETEQ HIKVPASMTA EELTLEILDR RNVGIREKDY WTCFEVNERE EAERPLHFAE KVLPILHGLG TDSHLVVKKH QAMEAMLLYL ASRVGDTKHG MMKFREDRSL LGLGLPSGGF HDRYFILNSS CLRLYKEVRS HRPEKEWPIK SLKVYLGVKK KLRPPTCWGF TVVHETEKHE KQQWYLCCDT QMELREWFAT FLFVQHDGLV WPSEPSRVSR AVPEVRLGSV SLIPLRGSEN EMRRSVAAFT ADPLSLLRNV; Positive Samples: 293T, LO2, HeLa, Mouse liver, Rat liver; Cellular Location: Cell membrane, Cytoplasm, Golgi apparatus, Golgi stack membrane, Peripheral membrane protein
ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeat. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: arap1; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; centaurin, delta 2; Centaurin-delta-2; Cnt-d2
Gene Aliases: 2410002L19Rik; Arap1; Centd2; Kiaa0782; mKIAA0782
UniProt ID: (Mouse) Q4LDD4
Entrez Gene ID: (Mouse) 69710, (Rat) 361617
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support