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Product Details
H00005926-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
2G8
Immunogen
ARID4A (NP_002883, 1033 a.a. approximately 1139 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: AEESQEGLCE RESANGFETN VASGTCSIIV QERESREKGQ KRPSDGNSGL MAKKQKRTPK RTSAAAKNEK NGTGQSSDSE DLPVLDNSSK CTPVKHLNVS KPQKLAR
Target Information
ARID4A encodes a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARID domain-containing protein 4A; AT rich interactive domain 4A (RBP1-like); AT-rich interactive domain-containing protein 4A; RBBP-1; retinoblastoma binding protein 1; Retinoblastoma-binding protein 1
Gene Aliases: ARID4A; RBBP-1; RBBP1; RBP-1; RBP1
UniProt ID: (Human) P29374
Entrez Gene ID: (Human) 5926
regulation of gene expression by genetic imprinting
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
spermatogenesis
histone deacetylation
histone H4-K20 trimethylation
histone H3-K9 trimethylation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
erythrocyte development
histone H3-K4 trimethylation
establishment of Sertoli cell barrier
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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