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FIGURE: 1 / 3
Positive test controls include: HepG2, U-937, Mouse liver, Rat liver. The target is usually found in the following locations: Membrane, Secreted, Single-pass type II membrane protein.
Immunogen sequence: MTKEYQDLQH LDNEESDHHQ LRKGPPPPQP LLQRLCSGPR LLLLSLGLSL LLLVVVCVIG SQNSQLQEEL RGLRETFSNF TASTEAQVKG LSTQGGNVGR KMKSLESQLE KQQKDLSEDH SSLLLHVKQF VSDLRSLSCQ MAALQGNGSE
The asialoglycooprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) which mediates binding, internalization and degradation of extracellular glycoproteins that have exposed terminal galactose residues. The receptor is expressed on the surface of the hepatocytes in a polar manner, i. e. it is present on the sinusoidal and lateral plasma membranes but not on the bile canalicular membrane. The mammalian hepatic ASGPR mediate the endocytosis and degradation of serum proteins from which terminal sialic residues have been removed. The rat asialoglycoprotein receptor (ASGPR) consists of three polypeptide subunits: rat hepatic lectin (RHL)-1, RHL-2 and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 of rat ASGPR. The monoclonal antibody 8D7 is cross reactive with human ASGPR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ASGP-R 1; ASGPR 1; asialoglycoprotein receptor (RHL1); Asialoglycoprotein receptor 1; Asialoglycoprotein receptor 1 (hepatic lectin); asialoglycoprotein receptor RHL1; C-type lectin domain family 4 member H1; Hepatic lectin 1; hepatic lectin 1 RHL1; hepatic lectin 1, RHL1; Hepatic lectin H1; HL-1; RHL-1
Gene Aliases: ASGPR; ASGPR1; ASGR; Asgr-1; ASGR1; CLEC4H1; HL-1; RATRHL1; RHL1
UniProt ID: (Human) P07306, (Rat) P02706, (Mouse) P34927
Entrez Gene ID: (Human) 432, (Rat) 24210, (Mouse) 11889
Molecular Function:
membrane traffic protein
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