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Product Details
MA5-32923
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgE
Class
Monoclonal
Type
Antibody
Clone
1-11
Immunogen
Synthetic peptide within Human Atg12 aa 91-140.
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 40% Glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2802558
Target Information
ATG12, a member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APG 12; Apg12 (autophagy, yeast) homolog; APG12-like; ATG12 autophagy related 12 homolog; autophagy-related 12; Autophagy-related protein 12; OTTHUMP00000159129; Ubiquitin-like protein ATG12
Gene Aliases: 4931423H11Rik; A330058M13Rik; APG12; APG12L; ATG12; Atg12l; FBR93; HAPG12
UniProt ID: (Human) O94817, (Rat) Q2TBJ5, (Mouse) Q9CQY1
Entrez Gene ID: (Human) 9140, (Rat) 361321, (Mouse) 67526
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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