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Product Details
PA5-88281
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ATG16L1 (NP_1104305)
Conjugate
Form
Liquid
Concentration
1.32 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804798
Product Specific Information
Immunogen sequence: QEANRLNAEN EKDSRRRQAR LQKELAEAAK EPLPVEQDDD IEVIVDETSD HTEETSPVRA ISRAATKRLS QPAGGLLDSI TNIFGRRSVS SFPVPQDNVD T; Positive Samples: HT-29, MCF7, HeLa; Cellular Location: Cytoplasm, Peripheral membrane protein, Preautophagosomal structure membrane
Target Information
Autophagy related protein 16 L is encoded by the ATG16L gene and is located on chromosome 2 in humans. It is also known as WD30 or IBD10 (Inflammatory Bowel Disease 10). ATG 12 and ATG5 conjugate with each other and undergoes homo oligomerisation with ATG16L to form an 800 kDa complex called the Atg16L complex. This complex facilitates coupling or lipidation of LC3 to phosphatidylethanolamine (PE) and this ubiquitin-like conjugation system is a widely used marker for autophagy. However, the ATG 16L complex along with other ATGs like ATG 18 and ATG 21 prevent the premature cleavage of ATG8-PE by the cysteine protease, Atg4 until the autophagosome is deemed complete.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A16L1; APG 16-L1; APG16-like 1; APG16L beta; APG16L isoforms 1; atg16; ATG16 autophagy related 16-like 1; Atg16L1 gamma; autophagy related 16-like 1; autophagy-related 16-like 1; autophagy-related 16-like 1 gamma; Autophagy-related protein 16-1; hCG_1817841; WD repeat domain 30
Gene Aliases: 1500009K01Rik; APG16L; ATG16A; ATG16L; ATG16L1; IBD10; UNQ9393/PRO34307; WDR30
UniProt ID: (Human) Q676U5, (Mouse) Q8C0J2
Entrez Gene ID: (Human) 55054, (Mouse) 77040, (Rat) 363278
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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