Proteintech

ATGL Polyclonal Antibody

ATGL Antibody in Immunocytochemistry (ICC/IF)

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ATGL Antibody (55190-1-AP) in ICC/IF

Immunofluorescent analysis of A431 cells using 55190-1-AP (ATGL antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IGG.

ATGL Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

55190-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 39 publications 39 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:10-1:100

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to ATGL.

Target Information

Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Wed Jan 25 00:00:00 EST 2023

Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.

Cell reports

Li L,Sun H,Chen J,Ding C,Yang X,Han H,Sun Q

Tue Jul 25 00:00:00 EDT 2023

Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.

Inflammation

Song Z,Liu N,He Y,Chen J,Li J,Wang F,Wu Z

Wed Feb 01 00:00:00 EST 2023

Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization.

Journal of cellular and molecular medicine

Li L,Cao X,Huang L,Huang X,Gu J,Yu X,Zhu Y,Zhou Y,Song Y,Zhu M

Mon May 01 00:00:00 EDT 2023

Activation of Atg5-dependent placental lipophagy ameliorates cadmium-induced fetal growth restriction.

Environmental pollution (Barking, Essex : 1987)

Zhang YF,Zhu HL,Xu XF,Zhang J,Ling Q,Zhang S,Chang W,Xiong YW,Xu DX,Wang H

Sat Jul 01 00:00:00 EDT 2023

Activation of Atg5-dependent placental lipophagy ameliorates cadmium-induced fetal growth restriction.

Environmental pollution (Barking, Essex : 1987)

Zhang YF,Zhu HL,Xu XF,Zhang J,Ling Q,Zhang S,Chang W,Xiong YW,Xu DX,Wang H

Sat Jul 01 00:00:00 EDT 2023

Activation of Atg5-dependent placental lipophagy ameliorates cadmium-induced fetal growth restriction.

Environmental pollution (Barking, Essex : 1987)

Zhang YF,Zhu HL,Xu XF,Zhang J,Ling Q,Zhang S,Chang W,Xiong YW,Xu DX,Wang H

Sat Jul 01 00:00:00 EDT 2023

Activation of Atg5-dependent placental lipophagy ameliorates cadmium-induced fetal growth restriction.

Environmental pollution (Barking, Essex : 1987)

Zhang YF,Zhu HL,Xu XF,Zhang J,Ling Q,Zhang S,Chang W,Xiong YW,Xu DX,Wang H

Sat Jul 01 00:00:00 EDT 2023

5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation.

Life sciences

Zong Y,Wang M,Liu Y,Suo X,Fan G,Yang X

Thu Jun 15 00:00:00 EDT 2023

Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration.

Journal of lipid research

Bernardo-Colón A,Dong L,Abu-Asab M,Brush RS,Agbaga MP,Becerra SP

Mon May 01 00:00:00 EDT 2023

Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1α-dependent fat catabolism in immortalized human bronchial epithelial cells.

Toxicology mechanisms and methods

Ye F,Zeng Q,Dan G,Zhao Y,Yu W,Cheng J,Chen M,Wang B,Zhao J,Sai Y,Zou Z

Mon May 01 00:00:00 EDT 2023

Toxicology mechanisms and methods

Ye F,Zeng Q,Dan G,Zhao Y,Yu W,Cheng J,Chen M,Wang B,Zhao J,Sai Y,Zou Z

Mon May 01 00:00:00 EDT 2023

Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.

Cellular signalling

Tian J,Zhang L,La X,Fan X,Li A,Wu C,An Y,Yan S,Dong X,Wu H,Li Z

Tue Aug 01 00:00:00 EDT 2023

Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.

Cellular signalling

Tian J,Zhang L,La X,Fan X,Li A,Wu C,An Y,Yan S,Dong X,Wu H,Li Z

Tue Aug 01 00:00:00 EDT 2023

Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.

Cellular signalling

Tian J,Zhang L,La X,Fan X,Li A,Wu C,An Y,Yan S,Dong X,Wu H,Li Z

Tue Aug 01 00:00:00 EDT 2023

Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease.

Annals of hepatology

Cook JJ,Wei M,Segovia B,Cosio-Lima L,Simpson J,Taylor S,Koh Y,Kim S,Lee Y

Thu Jul 07 00:00:00 EDT 2022

Graphene oxide links alterations of anti-viral signaling pathways with lipid metabolism via suppressing TLR3 in vascular smooth muscle cells.

Molecular omics

Luo Y,Li J,Huang C,Wang X,Long D,Cao Y

Mon Sep 26 00:00:00 EDT 2022

Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.

Journal of genetics and genomics = Yi chuan xue bao

Wu J,Chen Y,Li X,Ran L,Liu X,Wang X,Zhen M,Shao S,Zeng L,Wang C,Liang B,Zhao J,Wu Y

Fri Apr 01 00:00:00 EDT 2022

Aerobic exercise promotes the expression of ATGL and attenuates inflammation to improve hepatic steatosis via lncRNA SRA.

Scientific reports

Wu B,Xu C,Tian Y,Zeng Y,Yan F,Chen A,Zhao J,Chen L

Wed Mar 30 00:00:00 EDT 2022

FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.

Molecular neurobiology

Zhou B,Zheng Y,Li X,Dong H,Yu J,Zou Y,Zhu M,Yu Y,Fang X,Zhou M,Zhang W,Yuan Y,Wang Z,Deng J,Hong D

Thu Dec 01 00:00:00 EST 2022

Human gingival mesenchymal stem cells improve movement disorders and tyrosine hydroxylase neuronal damage in Parkinson disease rats.

Cytotherapy

Lei T,Xiao Z,Zhang X,Cai S,Bi W,Yang Y,Wang D,Li Q,Du H

Tue Nov 01 00:00:00 EDT 2022

Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH).

Nature communications

Li X,Ding K,Li X,Yuan B,Wang Y,Yao Z,Wang S,Huang H,Xu B,Xie L,Deng T,Chen XW,Chen Z

Thu Aug 04 00:00:00 EDT 2022

Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.

Food & function

Zhang J,Ma X,Fan D

Mon Feb 07 00:00:00 EST 2022

Phenotypic and genotypic changes in obesity and type 2 diabetes of male KK mice with aging.

Experimental animals

Iizuka Y,Kim H,Nakasatomi M,Matsumoto A,Shimizu J

Wed Feb 09 00:00:00 EST 2022

Pu-erh tea increases the metabolite Cinnabarinic acid to improve circadian rhythm disorder-induced obesity.

Food chemistry

Hu S,Hu C,Luo L,Zhang H,Zhao S,Liu Z,Zeng L

Tue Nov 15 00:00:00 EST 2022

Lipid metabolism is involved in the association of rotavirus viroplasms with endoplasmic reticulum membranes.

Virology

Martínez JL,Eichwald C,Schraner EM,López S,Arias CF

Fri Apr 01 00:00:00 EDT 2022

Lipid metabolism is involved in the association of rotavirus viroplasms with endoplasmic reticulum membranes.

Virology

Martínez JL,Eichwald C,Schraner EM,López S,Arias CF

Fri Apr 01 00:00:00 EDT 2022

CircRNA-mediated regulation of brown adipose tissue adipogenesis.

Frontiers in nutrition

Liu K,Liu X,Deng Y,Li Z,Tang A

Tue Aug 16 00:00:00 EDT 2022

The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.

iScience

Zhang G,Han J,Wang L,Yang X,Yan Z,Qu M,Zhou H,Bilal H,Wang F,Ge H,Yang X

Fri Apr 15 00:00:00 EDT 2022

Polyphyllin I improves myocardial damage in coronary artery disease via modulating lipid metabolism and myocardial apoptosis.

Journal of biochemical and molecular toxicology

Yang Z,Yang X,An M

Thu Dec 01 00:00:00 EST 2022

Baicalin ameliorates alcohol-induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL.

Archives of biochemistry and biophysics

Li P,Chen Y,Ke X,Zhang R,Zuo L,Wang M,Chen Z,Luo X,Wang J

Wed Jun 15 00:00:00 EDT 2022

Microalgae oil from Schizochytrium sp. alleviates obesity and modulates gut microbiota in high-fat diet-fed mice.

Food & function

Ran L,Yu J,Ma R,Yao Q,Wang M,Bi Y,Yu Z,Wu Y

Tue Dec 13 00:00:00 EST 2022

Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.

Life sciences

Li H,Dun Y,Zhang W,You B,Liu Y,Fu S,Qiu L,Cheng J,Ripley-Gonzalez JW,Liu S

Sat May 15 00:00:00 EDT 2021

Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R).

Investigative ophthalmology & visual science

Bullock J,Polato F,Abu-Asab M,Bernardo-Colón A,Aflaki E,Agbaga MP,Becerra SP

Mon Feb 01 00:00:00 EST 2021

Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R).

Investigative ophthalmology & visual science

Bullock J,Polato F,Abu-Asab M,Bernardo-Colón A,Aflaki E,Agbaga MP,Becerra SP

Mon Feb 01 00:00:00 EST 2021

Quantitative proteomic analysis identified differentially expressed proteins with tail/rump fat deposition in Chinese thin- and fat-tailed lambs.

PloS one

Han J,Guo T,Yue Y,Lu Z,Liu J,Yuan C,Niu C,Yang M,Yang B

Mon Jul 26 00:00:00 EDT 2021

Single-cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin.

Journal of pineal research

Li Z,Zheng M,Mo J,Li K,Yang X,Guo L,Zhang X,Abdalla BA,Nie Q

Thu Apr 01 00:00:00 EDT 2021

Function of Chick Subcutaneous Adipose Tissue During the Embryonic and Posthatch Period.

Frontiers in physiology

Zhao H,Wu M,Tang X,Li Q,Yi X,Wang S,Jia C,Wei Z,Sun X

Sat Jul 10 00:00:00 EDT 2021

Sulfated glucuronomannan hexasaccharide G6S1 enhanced lipolysis and lipophagy via PPARα pathway.

The international journal of biochemistry & cell biology

Cai M,Chen Y,Wang Y,Fang Q,He X,Wu W,Bao Y,Mao G,Jin W,Zhong W

Fri Oct 01 00:00:00 EDT 2021

Pigment epithelium-derived factor (PEDF) and derived peptides promote survival and differentiation of photoreceptors and induce neurite-outgrowth in amacrine neurons.

Journal of neurochemistry

Michelis G,German OL,Villasmil R,Soto T,Rotstein NP,Politi L,Becerra SP

Wed Dec 01 00:00:00 EST 2021

Inhibition of PAI-1 Promotes Lipolysis and Enhances Weight Loss in Obese Mice.

Obesity (Silver Spring, Md.)

Levine JA,Olivares S,Miyata T,Vaughan DE,Henkel AS

Thu Apr 01 00:00:00 EDT 2021

Myostatin suppresses adipogenic differentiation and lipid accumulation by activating crosstalk between ERK1/2 and PKA signaling pathways in porcine subcutaneous preadipocytes.

Journal of animal science

Pan S,Zhang L,Liu Z,Xing H

Wed Dec 01 00:00:00 EST 2021

CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.

Hepatology (Baltimore, Md.)

Zhang H,Zhang C,Tang H,Gao S,Sun F,Yang Y,Zhou W,Hu Y,Ke C,Wu Y,Ding Z,Guo L,Pei R,Chen X,Sy MS,Zhang B,Li C

Thu Nov 01 00:00:00 EDT 2018

mRNA m⁶A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.

International journal of obesity (2005)

Wang X,Sun B,Jiang Q,Wu R,Cai M,Yao Y,Liu Q,Shi H,Feng J,Wang Y

Thu Nov 01 00:00:00 EDT 2018

mRNA m⁶A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.

International journal of obesity (2005)

Wang X,Sun B,Jiang Q,Wu R,Cai M,Yao Y,Liu Q,Shi H,Feng J,Wang Y

Thu Nov 01 00:00:00 EDT 2018

PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R.

International journal of molecular medicine

Zhao Q,Liu Z,Huang B,Yuan Y,Liu X,Zhang H,Qiu F,Zhang Y,Li Y,Miao H,Dong H,Zhang Z

Fri Jun 01 00:00:00 EDT 2018

PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R.

International journal of molecular medicine

Zhao Q,Liu Z,Huang B,Yuan Y,Liu X,Zhang H,Qiu F,Zhang Y,Li Y,Miao H,Dong H,Zhang Z

Fri Jun 01 00:00:00 EDT 2018

PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R.

International journal of molecular medicine

Zhao Q,Liu Z,Huang B,Yuan Y,Liu X,Zhang H,Qiu F,Zhang Y,Li Y,Miao H,Dong H,Zhang Z

Fri Jun 01 00:00:00 EDT 2018

PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R.

International journal of molecular medicine

Zhao Q,Liu Z,Huang B,Yuan Y,Liu X,Zhang H,Qiu F,Zhang Y,Li Y,Miao H,Dong H,Zhang Z

Fri Jun 01 00:00:00 EDT 2018

miR-128-3p regulates 3T3-L1 adipogenesis and lipolysis by targeting Pparg and Sertad2.

Journal of physiology and biochemistry

Chen C,Deng Y,Hu X,Ren H,Zhu J,Fu S,Xie J,Peng Y

Wed Aug 01 00:00:00 EDT 2018

miR-128-3p regulates 3T3-L1 adipogenesis and lipolysis by targeting Pparg and Sertad2.

Journal of physiology and biochemistry

Chen C,Deng Y,Hu X,Ren H,Zhu J,Fu S,Xie J,Peng Y

Wed Aug 01 00:00:00 EDT 2018

Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes dysfunction.

Scientific reports

Qiang G,Whang Kong H,Gil V,Liew CW

Mon Jan 09 00:00:00 EST 2017

Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes dysfunction.

Scientific reports

Qiang G,Whang Kong H,Gil V,Liew CW

Mon Jan 09 00:00:00 EST 2017

Loss of ABHD5 promotes the aggressiveness of prostate cancer cells.

Scientific reports

Chen G,Zhou G,Aras S,He Z,Lucas S,Podgorski I,Skar W,Granneman JG,Wang J

Thu Oct 12 00:00:00 EDT 2017

Loss of ABHD5 promotes the aggressiveness of prostate cancer cells.

Scientific reports

Chen G,Zhou G,Aras S,He Z,Lucas S,Podgorski I,Skar W,Granneman JG,Wang J

Thu Oct 12 00:00:00 EDT 2017

GLP-1/GLP-1R Signaling in Regulation of Adipocyte Differentiation and Lipogenesis.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Chen J,Zhao H,Ma X,Zhang Y,Lu S,Wang Y,Zong C,Qin D,Wang Y,Yingfeng Yang Y,Wang X,Liu Y

Tue Nov 07 00:00:00 EST 2017

Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity.

Scientific reports

Jia L,Li W,Li J,Li Y,Song H,Luan Y,Qi H,Ma L,Lu X,Yang Y

Tue Nov 08 00:00:00 EST 2016

Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity.

Scientific reports

Jia L,Li W,Li J,Li Y,Song H,Luan Y,Qi H,Ma L,Lu X,Yang Y

Tue Nov 08 00:00:00 EST 2016

Bioinformatics

Protein Aliases: Adipose triglyceride lipase; ATGL DESNUTRIN; calcium-independent phospholipase A2; Calcium-independent phospholipase A2-zeta; Desnutrin; DKFZp667M109; IPLA2 zeta; IPLA2-zeta; mutant patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing protein 2; Patatin-like phospholipase domain-containing protein 2; PEDF R; PEDF-R; pigment epithelium-derived factor; Pigment epithelium-derived factor receptor; plpl; plpl2; transport-secretion protein; Transport-secretion protein 2; transport-secretion protein 2.2; triglyceride hydrolase; TTS 2.2; TTS2; TTS2.2

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Gene Aliases: 0610039C21Rik; 1110001C14Rik; ATGL; FP17548; iPLA2zeta; PEDF-R; PNPLA2; RGD1309044; TTS-2.2; TTS2

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UniProt ID: (Human) Q96AD5, (Rat) P0C548, (Mouse) Q8BJ56

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Entrez Gene ID: (Human) 57104, (Rat) 361676, (Mouse) 66853

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Function(s)

lipoprotein lipase activity triglyceride lipase activity acylglycerol O-acyltransferase activity protein binding hydrolase activity phospholipase

Process(es)

negative regulation of sequestering of triglyceride positive regulation of triglyceride catabolic process triglyceride catabolic process lipid storage lipid particle organization acylglycerol acyl-chain remodeling lipid homeostasis lipid metabolic process metabolic process lipid catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ATGL Polyclonal Antibody

ATGL Antibody (55190-1-AP) in ICC/IF

Product Details

55190-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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