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ATGL Antibody (PA5-29064) in WB
Western Blot analysis of ATGL was performed by separating 50 µg of Mouse tissue extracts by 7.5% SDS-PAGE. Proteins were transferred to a membrane and probed with a ATGL Polyclonal Antibody (Product # PA5-29064) at a dilution of 1:1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Product Details
PA5-29064
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 41 and 329 of Human PNPLA2
Conjugate
Form
Liquid
Concentration
2.97 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546540
Product Specific Information
Recommended positive controls: A549, H1299, HCT116, mouse white adipose.
Predicted reactivity: Mouse (83%), Rat (83%), Pig (80%), Sheep (85%), Bovine (84%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adipose triglyceride lipase; ATGL DESNUTRIN; calcium-independent phospholipase A2; Calcium-independent phospholipase A2-zeta; Desnutrin; DKFZp667M109; IPLA2 zeta; IPLA2-zeta; mutant patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain containing protein 2; Patatin-like phospholipase domain-containing protein 2; PEDF R; PEDF-R; pigment epithelium-derived factor; Pigment epithelium-derived factor receptor; plpl; plpl2; transport-secretion protein; Transport-secretion protein 2; transport-secretion protein 2.2; triglyceride hydrolase; TTS 2.2; TTS2; TTS2.2
Gene Aliases: 0610039C21Rik; 1110001C14Rik; ATGL; FP17548; iPLA2zeta; PEDF-R; PNPLA2; TTS-2.2; TTS2
UniProt ID: (Human) Q96AD5, (Mouse) Q8BJ56
Entrez Gene ID: (Human) 57104, (Mouse) 66853
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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