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Product Details
PA5-148210
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the N-terminus of the Mouse ATP1A3
Conjugate
Form
Liquid
Concentration
100 µg/mL
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7
Contains
0.03% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Human and rat predicted to react based on 100% sequence homology.
Target Information
The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the alpha subunit, and an associated smaller glycoprotein, termed the beta subunit. Studies indicate that there are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1 and beta 2) encoded by two multigene families. The different isoforms of the sodium/potassium ATPase exhibit tissue-specific and developmental patterns of expression. The alpha 1 and beta mRNAs are present in all cell types examined, whereas the alpha 2 and alpha 3 mRNAs exhibit a more restricted pattern of cell-specific expression. The alpha-3 subunit has been found in neuronal and to skeletal and cardiac muscle, lung and stomach tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.6.3.9; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; Sodium Potassium ATPase; Sodium pump 3; Sodium pump subunit alpha-3; Sodium/potassium-transporting ATPase subunit alpha-3
Gene Aliases: Atp1a3; Atpa-2
UniProt ID: (Mouse) Q6PIC6
Entrez Gene ID: (Mouse) 232975
nucleotide binding
sodium:potassium-exchanging ATPase activity
ATP binding
hydrolase activity
D1 dopamine receptor binding
heparan sulfate proteoglycan binding
metal ion binding
chaperone binding
sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
primary active transporter
transport
ion transport
potassium ion transport
sodium ion transport
cellular sodium ion homeostasis
memory
adult locomotory behavior
visual learning
potassium ion import
cellular potassium ion homeostasis
ionotropic glutamate receptor signaling pathway
sodium ion transmembrane transport
sodium ion export from cell
response to drug
cardiac muscle contraction
potassium ion transmembrane transport
regulation of cardiac muscle cell membrane potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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