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ATP1A3 (C-terminal) Antibody (10868-1-AP) in IHC (P)
Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue slide using (Product # 10868-1-AP) ATP1A3 (C-terminal) antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Product Details
10868-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATP1A3 (C-terminal) Fusion Protein Ag1313 (665-1013 aa encoded by BC015566)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is generated against the C-terminal region (665-1013aa) of ATP1A3 and detects the band around 100-113 kDa in SDS-PAGE.
Immunogen sequence: SEQIDEILQ NHTEIVFART SPQQKLIIVE GCQRQGAIVA VTGDGVNDSP ALKKADIGVA MGIAGSDVSK QAADMILLDD NFASIVTGVE EGRLIFDNLK KSIAYTLTSN IPEITPFLLF IMANIPLPLG TITILCIDLG TDMVPAISLA YEAAESDIMK RQPRNPRTDK LVNERLISMA YGQIGMIQAL GGFFSYFVIL AENGFLPGNL VGIRLNWDDR TVNDLEDSYG QQWTYEQRKV VEFTCHTAFF VSIVVVQWAD LIICKTRRNS VFQQGMKNKI LIFGLFEETA LAAFLSYCPG MDVALRMYPL KPSWWFCAFP YSFLIFVYDE IRKLILRRNP GGWVEKETYY (665-1013 aa encoded by BC015566)
Target Information
The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the alpha subunit, and an associated smaller glycoprotein, termed the beta subunit. Studies indicate that there are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1 and beta 2) encoded by two multigene families. The different isoforms of the sodium/potassium ATPase exhibit tissue-specific and developmental patterns of expression. The alpha 1 and beta mRNAs are present in all cell types examined, whereas the alpha 2 and alpha 3 mRNAs exhibit a more restricted pattern of cell-specific expression. The alpha-3 subunit has been found in neuronal and to skeletal and cardiac muscle, lung and stomach tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATPase, Na+/K+ transporting, alpha 3 polypeptide; ATPase, Na+K+ transporting, alpha 3 subunit; EC 3.6.3.9; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; Na+, K+ activated adenosine triphosphatase alpha subunit; Na+/K+ -ATPase alpha 3 subunit; Na+/K+ ATPase 3; Sodium Potassium ATPase; Sodium pump 3; Sodium pump subunit alpha-3; sodium-potassium ATPase catalytic subunit alpha-3; sodium-potassium-ATPase, alpha 3 polypeptide; sodium/potassium-transporting ATPase alpha-3 chain; Sodium/potassium-transporting ATPase subunit alpha-3
Gene Aliases: AHC2; ATP1A1; ATP1A3; Atpa-2; Atpa1a3; CAPOS; DYT12; RDP
UniProt ID: (Human) P13637, (Rat) P06687, (Mouse) Q6PIC6
Entrez Gene ID: (Human) 478, (Rat) 24213, (Mouse) 232975
sodium:potassium-exchanging ATPase activity
ATP binding
D1 dopamine receptor binding
heparan sulfate proteoglycan binding
metal ion binding
chaperone binding
sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential
steroid hormone binding
protein binding
cation-transporting ATPase activity
nucleotide binding
hydrolase activity
primary active transporter
cellular sodium ion homeostasis
memory
adult locomotory behavior
visual learning
potassium ion import
establishment or maintenance of transmembrane electrochemical gradient
ATP hydrolysis coupled proton transport
cellular potassium ion homeostasis
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
sodium ion export from cell
response to drug
cardiac muscle contraction
cellular response to steroid hormone stimulus
regulation of cardiac muscle cell membrane potential
cell communication by electrical coupling involved in cardiac conduction
response to glycoside
regulation of cardiac conduction
potassium ion transport
sodium ion transport
metabolic process
transport
ion transport
sodium ion transmembrane transport
potassium ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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