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Invitrogen
ATP1B1 Monoclonal Antibody (464.8 (aka 8A))
Product Details
MA1-16732
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Hamster,
Human,
Pig,
Rabbit,
Rat,
Xenopus
Published species
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
464.8 (aka 8A)
Immunogen
Purified Na,K-ATPase from rabbit renal outer medulla.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2060998
Product Specific Information
This antibody does not react with mouse samples.
Target Information
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adenosinetriphosphatase; ATPase, Na+/K+ transporting, beta 1 polypeptide; Beta 1-subunit of Na(+),K(+)-ATPase; MGC1798; Na+, K+-ATPase; Na+, K+-ATPase beta-subunit; Na+,K+-ATPase beta 1 subunit; Na+/K+ ATPase Beta; Na, K-ATPase beta-1 polypeptide; Na,K-ATPase beta 1 subunit; OTTHUMP00000032537; OTTHUMP00000032538; P-type ATPase; Sodium Potassium ATPase; sodium pump subunit beta-1; sodium-potassium ATPase subunit beta 1 (non-catalytic); sodium/potassium ATPase beta subunit; sodium/potassium-dependent ATPase beta-1 subunit; Sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase beta-1 chain; Sodium/potassium-transporting ATPase subunit beta-1; unnamed protein product
Gene Aliases: ATP1B; ATP1B1; ATPBS
UniProt ID: (Pig) P05027, (Rabbit) Q9TT37, (Human) Q5TGZ3, (Chicken) P08251, (Rat) P07340
cell adhesion
establishment or maintenance of transmembrane electrochemical gradient
positive regulation of ATPase activity
cellular calcium ion homeostasis
cellular sodium ion homeostasis
regulation of gene expression
regulation of cardiac muscle contraction by calcium ion signaling
cellular potassium ion homeostasis
sodium ion export from cell
ATP metabolic process
protein stabilization
transmembrane transport
relaxation of cardiac muscle
cardiac muscle contraction
protein localization to plasma membrane
membrane repolarization
positive regulation of potassium ion transmembrane transporter activity
positive regulation of sodium ion export from cell
positive regulation of calcium:sodium antiporter activity
positive regulation of potassium ion import
potassium ion import across plasma membrane
response to hypoxia
positive regulation of defense response to virus by host
potassium ion import
ion transmembrane transport
protein transport into plasma membrane raft
leukocyte migration
membrane repolarization during cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
ATP hydrolysis coupled transmembrane transport
mitophagy in response to mitochondrial depolarization
xenophagy
regulation of cardiac conduction
blastocyst development
potassium ion transport
sodium ion transport
metal ion transport
regulation of calcium ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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