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AVPR2 Antibody (PA5-109435) in WB
Western blot analysis of AVPR2 in extracts of various cell lines. Samples were incubated with AVPR2 Polyclonal antibody (Product # PA5-109435) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-109435
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 232-371 of human AVPR2 (NP_000045.1).
Conjugate
Form
Liquid
Concentration
0.72 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2854846
Product Specific Information
Immunogen sequence: IHASLVPGPS ERPGGRRRGR RTGSPGEGAH VSAAVAKTVR MTLVIVVVYV LCWAPFFLVQ LWAAWDPEAP LEGAPFVLLM LLASLNSCTN PWIYASFSSS VSSELRSLLC CARGRTPPSL GPQDESCTTA SSSLAKDTSS
Target Information
Avpr2 is a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. Avpr2 has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. Avpr2 can contract smooth muscle during parturition and lactation. Avpr2 is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. The activity of Avpr2 is mediated by G proteins which activate adenylate cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Antidiuretic hormone receptor; Avp2r; AVPR V2; MGC126533; MGC138386; Renal-type arginine vasopressin receptor; V2-renal V2R; V2R; Vasopressin V2 receptor
Gene Aliases: ADHR; AVPR2; DI1; DIR; DIR3; NDI; V2R
UniProt ID: (Human) P30518
Entrez Gene ID: (Human) 554
regulation of systemic arterial blood pressure by vasopressin
positive regulation of systemic arterial blood pressure
renal water homeostasis
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
I-kappaB kinase/NF-kappaB signaling
excretion
hemostasis
positive regulation of cell proliferation
positive regulation of gene expression
telencephalon development
positive regulation of protein ubiquitination
interferon-gamma production
cellular response to hormone stimulus
response to cytokine
negative regulation of urine volume
negative regulation of renal sodium excretion
positive regulation of vasoconstriction
response to peptide
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