Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Proteintech's AXIN1 antibody 16541-1-AP is a rabbit polyclonal antibody raised against the N-terminus of human AXIN1.
Immunogen sequence: MNIQEQGFP LDLGASFTED APRPPVPGEE GELVSTDPRP ASYSFCSGKG VGIKGETSTA TPRRSDLDLG YEPEGSASPT PPYLKWAESL HSLLDDQDGI SLFRTFLKQE GCADLLDFWF ACTGFRKLEP CDSNEEKRLK LARAIYRKYI LDNNGIVSRQ TKPATKSFIK GCIMKQLIDP AMFDQAQTEI QATMEENTYP SFLKSDIYLE YTRTGSESPK VCSDQSSGSG TGKGISGYLP TLNEDEEWKC DQDMDEDDGR DAAPPGRLPQ KLLLETAAPR VSSSRRYSEG REFRYGSWRE PVNPYYVNAG YALAPATSAN DSEQQSLSSD ADTLSLTDSS VDGIPPYRIR KQ (1-351 aa encoded by BC044648)
AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Axin-1; Axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; hAxin; LA16c-314G4.3; MGC52315; protein phosphatase 1, regulatory subunit 49
Gene Aliases: AXIN; AXIN1; PPP1R49
UniProt ID: (Human) O15169
Entrez Gene ID: (Human) 8312
Molecular Function: scaffold/adaptor protein
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