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Product Details
H00000558-M02
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
6G1
Immunogen
AXL (AAH32229, 30 a.a. approximately 140 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: TQAEESPFVG NPGNITGARG LTGTLRCQLQ VQGEPPEVHW LRDGQILELA DSTQTQVPLG EDEQDDWIVV SQLRITSLQL SDTGQYQCLV FLGHQTFVSQ PGYVGLEGLP Y
Target Information
AXL is a chronic myelogenous leukemia-associated oncogene that is also associated with colon cancer and melanoma. The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6, and is involved in the stimulation of cell proliferation. TAM receptors are also involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad spectrum auto-antibodies. In addition, Axl may function as a putative entry receptor for filoviruses. Axl is also used to identify a specific subpopulation of human blood dendritic cells, also referred to as Siglec 6+/Axl+ dendritic cells. Cellular expression of Axl can be upregulated by TLR ligands, such as LPS or poly I:C. Soluble Axl is generated by proteolytic cleavage of the membrane form. Increased plasma levels may be indicative of inflammation and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AXL oncogene; AXL transforming sequence/gene; AZF1; oncogene AXL; sAXL; soluble AXL; Tyrosine-protein kinase receptor UFO
Gene Aliases: ARK; AXL; JTK11; Tyro7; UFO
UniProt ID: (Human) P30530
Entrez Gene ID: (Human) 558
neuron migration
natural killer cell differentiation
positive regulation of cytokine-mediated signaling pathway
blood vessel remodeling
phagocytosis
inflammatory response
signal transduction
spermatogenesis
peptidyl-tyrosine phosphorylation
forebrain cell migration
platelet activation
cellular response to extracellular stimulus
negative regulation of interferon-gamma production
negative regulation of tumor necrosis factor production
positive regulation of natural killer cell differentiation
secretion by cell
erythrocyte homeostasis
substrate adhesion-dependent cell spreading
cellular response to interferon-alpha
ovulation cycle
apoptotic cell clearance
protein kinase B signaling
negative regulation of neuron apoptotic process
innate immune response
viral entry into host cell
vascular endothelial growth factor receptor signaling pathway
cell maturation
positive regulation of pinocytosis
negative regulation of lymphocyte activation
positive regulation of protein kinase B signaling
vagina development
cellular response to lipopolysaccharide
dendritic cell differentiation
negative regulation of dendritic cell apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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