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Invitrogen
Abciximab Chimeric Recombinant Human Monoclonal Antibody
FIGURE: 1 / 1
Abciximab Chimeric Antibody (MA5-41766) in SDS-PAGE
SDS-PAGE analysis of the recombinant Human ITGA2B_ITGB3 protein expressed in CHO cells using a Abciximab biosimilar monoclonal antibody (Product # MA5-41766). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
Product Details
MA5-41766
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1, F(ab), kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Human ITGA2B_ITGB3
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein L
Storage buffer
PBS, pH 7.5
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2910909
Product Specific Information
Purity >95%
Endotoxin level <10EU/mg by LAL method.
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
Target Information
Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (alpha-v-beta-3) receptor found on platelets and vessel wall endothelial and smooth muscle cells. Abciximab binds to the intact platelet GpiIb/IIIa receptor, which is a member of the integrin family of adhesion receptors and the major platelet surface receptor involved in platelet aggregation. This binding is thought to involve steric hindrance and/or conformational alterations which block access of large molecules to the receptor rather than direct interaction with the RGD (arginine-glycine-aspartic acid) binding site of GpiIb/IIIa. By binding to the vitronectin receptor (also known as the alpha-v-beta-3 integrin), abciximab blocks effects mediated by this integrin which include cell adhesion. Furthermore, abciximab blocks Mac-1 receptor on monocytes and neutrophils thus inhibiting monocyte adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c7E3
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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