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Invitrogen
Acetyl-CoA Carboxylase Polyclonal Antibody
FIGURE: 1 / 6
Acetyl-CoA Carboxylase Antibody (PA5-90578) in ICC/IF
Immunofluorescence analysis of Acetyl-CoA Carboxylase in NIH/3T3 cells. Samples were incubated with Acetyl-CoA Carboxylase Polyclonal antibody (Product # PA5-90578) using a dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Product Details
PA5-90578
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 2266-2346 of human ACC1 (NP_9421331)
Conjugate
Form
Liquid
Concentration
0.74 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806127
Product Specific Information
Positive Samples: HeLa, C2C12, C6; Cellular Location: Cytoplasm
Immunogen sequence: NNKDLAEWLE KQLTEEDGVH SVIEENIKCI SRDYVLKQIR SLVQANPEVA MDSIIHMTQH ISPTQRAEVI RILSTMDSPS T
Target Information
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acaca; ACC-alpha; ACC1; Acetyl-CoA carboxylase 1; Acetyl-CoA carboxylase 265; Acetyl-Coenzyme A carboxylase alpha; EC 6.3.4.14; EC 6.4.1.2
Gene Aliases: A530025K05Rik; ACAC; ACACA; ACACAD; ACC; ACC1; ACCA; Gm738
UniProt ID: (Human) Q13085, (Mouse) Q5SWU9, (Rat) P11497
Entrez Gene ID: (Human) 31, (Mouse) 107476, (Rat) 60581
tissue homeostasis
acetyl-CoA metabolic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
metabolic process
response to organic cyclic compound
multicellular organismal protein metabolic process
protein homotetramerization
lipid homeostasis
cellular response to prostaglandin E stimulus
biotin metabolic process
carnitine shuttle
positive regulation of cellular metabolic process
long-chain fatty-acyl-CoA biosynthetic process
malonyl-CoA biosynthetic process
response to drug
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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