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Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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Protein Aliases: H2B histone family, member F; H2B-clustered histone 3; H2B/f; H2BFF; HIST1H2BB; histone 1, H2bb; Histone H2B type 1-B; Histone H2B.1; Histone H2B.f
Gene Aliases: H2B.1; H2B/f; H2BC3; H2BFF; HIST1H2BB
UniProt ID: (Human) P33778
Entrez Gene ID: (Human) 3018
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