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Acetylcholinesterase Antibody (PA5-86086) in IHC (P)
Immunohistochemical analysis of Acetylcholinesterase in paraffin-embedded human rectum carcinoma tissue showing membrane/nuclear staining and negative control (right). Sample was incubated with polyclonal Acetylcholinesterase antibody (Product # PA5-86086) using a 1:50 dilution, and followed by goat anti-rabbit IgG-biotin and avidin-peroxidase secondary antibodies.
Product Details
PA5-86086
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to residues in Human AChE.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2802886
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. The Protein is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acetylcholinesterase; acetylcholinesterase (Yt blood group); AChE; apoptosis-related acetylcholinesterase; EC 3.1.1.7; glycolipid-anchored form of acetylcholinesterase; OTTHUMP00000211349; OTTHUMP00000211356; Yt blood group
Gene Aliases: ACEE; ACHE; ARACHE; N-ACHE; YT
UniProt ID: (Human) Q2M324, (Mouse) P21836, (Rat) P37136
Entrez Gene ID: (Human) 43, (Mouse) 11423, (Rat) 83817
beta-amyloid binding
acetylcholinesterase activity
cholinesterase activity
protein binding
collagen binding
hydrolase activity
serine hydrolase activity
acetylcholine binding
protein homodimerization activity
laminin binding
protein self-association
choline binding
carboxylic ester hydrolase activity
esterase
acetylcholine catabolic process in synaptic cleft
regulation of receptor recycling
osteoblast development
DNA replication
acetylcholine catabolic process
phosphatidylcholine biosynthetic process
cell adhesion
nervous system development
synapse assembly
muscle organ development
cell proliferation
response to wounding
receptor internalization
negative regulation of synaptic transmission, cholinergic
neurotransmitter biosynthetic process
amyloid precursor protein metabolic process
neurotransmitter receptor biosynthetic process
positive regulation of protein secretion
protein tetramerization
retina development in camera-type eye
acetylcholine metabolic process
choline metabolic process
neurotransmitter catabolic process
positive regulation of axonogenesis
positive regulation of dendrite morphogenesis
neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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