Proteintech

Aconitase 2 Polyclonal Antibody

Aconitase 2 Antibody in Immunocytochemistry (ICC/IF)

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Aconitase 2 Antibody (11134-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA ) fixed HeLa cells using 11134-1-AP (Aconitase 2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Aconitase 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Aconitase 2 Antibody in Western Blot (WB)

Product Image Gallery

Product Details

11134-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 14 publications 14 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Aconitase 2 Fusion Protein Ag1590 (1-300 aa encoded by BC014092)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.16 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAPYSLLVT RLQKALGVRQ YHVASVLCQR AKVAMSHFEP NEYIHYDLLE KNINIVRKRL NRPLTLSEKI VYGHLDDPAS QEIERGKSYL RLRPDRVAMQ DATAQMAMLQ FISSGLSKVA VPSTIHCDHL IEAQVGGEKD LRRAKDINQE VYNFLATAGA KYGVGFWKPG SGIIHQIILE NYAYPGVLLI GTDSHTPNGG GLGGICIGVG GADAVDVMAG IPWELKCPKV IGVKLTGSLS GWSSPKDVIL KVAGILTVKG GTGAIVEYHG PGVDSISCTG MATICNMGAE IGATTSVFPY N (1-300 aa encoded by BC014092)

Target Information

The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Sat Oct 01 00:00:00 EDT 2022

Cur@SF NPs alleviate Friedreich's ataxia in a mouse model through synergistic iron chelation and antioxidation.

Journal of nanobiotechnology

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Wed Mar 09 00:00:00 EST 2022

Proteomic Profile of Sperm in Infertile Males Reveals Changes in Metabolic Pathways.

The protein journal

Liang J,Zheng Y,Zeng W,Chen L,Yang S,Du P,Wang Y,Yu X,Zhang X

Wed Dec 01 00:00:00 EST 2021

Proteomic Profile of Sperm in Infertile Males Reveals Changes in Metabolic Pathways.

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Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.

Cell metabolism

Wang YP,Sharda A,Xu SN,van Gastel N,Man CH,Choi U,Leong WZ,Li X,Scadden DT

Tue May 04 00:00:00 EDT 2021

Bioenergetic functions in subpopulations of heart mitochondria are preserved in a non-obese type 2 diabetes rat model (Goto-Kakizaki).

Scientific reports

Lai N,Kummitha CM,Loy F,Isola R,Hoppel CL

Wed Mar 25 00:00:00 EDT 2020

The Symbiotic Relationship between the Neural Retina and Retinal Pigment Epithelium Is Supported by Utilizing Differential Metabolic Pathways.

iScience

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Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.

Toxicon : official journal of the International Society on Toxinology

Li C,Chen W,Zheng L,Zhang B,Yang X,Zhang Q,Wang N,Wang Y,Yang J,Sha J,Zhou Z,Li X,Li Y,Shen XL

Tue Oct 01 00:00:00 EDT 2019

miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism.

Cancer research

Muys BR,Sousa JF,Plaça JR,de Araújo LF,Sarshad AA,Anastasakis DG,Wang X,Li XL,de Molfetta GA,Ramão A,Lal A,Vidal DO,Hafner M,Silva WA

Mon Jul 01 00:00:00 EDT 2019

Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.

Scientific reports

Li H,Zhao H,Hao S,Shang L,Wu J,Song C,Meyron-Holtz EG,Qiao T,Li K

Fri Mar 23 00:00:00 EDT 2018

Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.

Scientific reports

Li H,Zhao H,Hao S,Shang L,Wu J,Song C,Meyron-Holtz EG,Qiao T,Li K

Fri Mar 23 00:00:00 EDT 2018

Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.

International journal of molecular sciences

Chen CM,Wu YR,Chang KH

Tue Nov 21 00:00:00 EST 2017

Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.

International journal of molecular sciences

Chen CM,Wu YR,Chang KH

Tue Nov 21 00:00:00 EST 2017

Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.

International journal of molecular sciences

Chen CM,Wu YR,Chang KH

Tue Nov 21 00:00:00 EST 2017

A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.

Cell reports

Pryde KR,Taanman JW,Schapira AH

Tue Dec 06 00:00:00 EST 2016

A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.

Cell reports

Pryde KR,Taanman JW,Schapira AH

Tue Dec 06 00:00:00 EST 2016

Tumor Necrosis Factor-Associated Protein 1 (TRAP1) is Released from the Mitochondria Following 6-hydroxydopamine Treatment.

Experimental neurobiology

Shin DI,Oh YJ

Sat Mar 01 00:00:00 EST 2014

Tumor Necrosis Factor-Associated Protein 1 (TRAP1) is Released from the Mitochondria Following 6-hydroxydopamine Treatment.

Experimental neurobiology

Shin DI,Oh YJ

Sat Mar 01 00:00:00 EST 2014

A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism.

Molecular & cellular proteomics : MCP

Cai Z,Zhao JS,Li JJ,Peng DN,Wang XY,Chen TL,Qiu YP,Chen PP,Li WJ,Xu LY,Li EM,Tam JP,Qi RZ,Jia W,Xie D

Wed Dec 01 00:00:00 EST 2010

A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism.

Molecular & cellular proteomics : MCP

Cai Z,Zhao JS,Li JJ,Peng DN,Wang XY,Chen TL,Qiu YP,Chen PP,Li WJ,Xu LY,Li EM,Tam JP,Qi RZ,Jia W,Xie D

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Bioinformatics

Protein Aliases: Aconitase; aconitase 2, mitochondrial; Aconitate hydratase, mitochondrial; Citrate hydro-lyase; epididymis secretory sperm binding protein Li 284; MGC20605; MGC33908; mitochondrial aconitase; mitochondrial aconitase (nuclear aco2 gene); RP3-347H13.8

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Gene Aliases: Aco-2; ACO2; Aco3; ACONM; D10Wsu183e; HEL-S-284; ICRD; OCA8; OPA9

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UniProt ID: (Human) Q99798, (Rat) Q9ER34, (Mouse) Q99KI0

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Entrez Gene ID: (Human) 50, (Rat) 79250, (Mouse) 11429

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Function(s)

aconitate hydratase activity iron ion binding 3 iron, 4 sulfur cluster binding 4 iron, 4 sulfur cluster binding protein binding lyase activity metal ion binding iron-sulfur cluster binding hydratase

Process(es)

generation of precursor metabolites and energy tricarboxylic acid cycle citrate metabolic process isocitrate metabolic process metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Aconitase 2 Polyclonal Antibody

Aconitase 2 Antibody (11134-1-AP) in ICC/IF

Product Details

11134-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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