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Product Details
651132
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Chicken,
Human,
Plant,
Rabbit
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
2G2
Immunogen
Profilin Actin Complex From Calf Thymus
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Specific for skeletal and non-muscle actin isoforms (MW 43,000). Epitope location: NVPAMYVAVLDSGVTHNVPIYHAIMWLDLA.
Target Information
Actin exists as a ubiquitous protein involved with filament formation that make up large portions of the cytoskeleton. Actin filaments interact with myosin to assist in muscle contraction as well as aiding in cell motility and cytokinesis. In vertebrates there are three groups of actin isoforms: alpha, beta and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exists in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a-actin; ACTB; actin; actin, alpha 2, smooth muscle, aorta; Actin, alpha cardiac muscle 1; Actin, alpha skeletal muscle; Actin, aortic smooth muscle; actin, beta; Actin, cytoplasmic 1; Actin, cytoplasmic 2; Actin, cytoplasmic type 5; actin, cytoplasmic, type 5; actin, gamma 1 propeptide; actin, gamma 2, smooth muscle, enteric; Actin, gamma-enteric smooth muscle; actin-like protein; alpha actin 2; Alpha-actin; Alpha-actin-1; Alpha-actin-2; Alpha-actin-3; Alpha-cardiac actin; alpha-sma; alpha-smooth muscle actin; Atcb; Bact; actin; beta cytoskeletal actin; Beta-actin; Cell growth-inhibiting gene 46 protein; cytoplasmic 1; cytoplasmic 2; cytoplasmic beta-actin; cytoplasmic type 5; cytoskeletal gamma-actin; deafness, autosomal dominant 20; deafness, autosomal dominant 26; epididymis luminal protein 176; gamma 1 propeptide; gamma non-muscle actin; Gamma-2-actin; Gamma-actin; nemaline myopathy type 3; pan actin; PS1TP5-binding protein 1; RP5-1068B5.2; Smooth muscle gamma-actin; type 5; unnamed protein product
Gene Aliases: AAT6; ACT; ACT-5; ACTA; ACTA1; ACTA2; ACTA3; ACTB; ACTC; ACTC1; ACTE; ACTG; ACTG1; ACTG2; actin; ACTL3; ACTSA; ACTSG; ACTVS; ASD5; ASMA; Bact; BRWS1; BRWS2; CFTD; CFTD1; CFTDM; CMD1R; CMH11; DFNA20; DFNA26; GAMMA-ACTIN; GIG46; HEL-176; LVNC4; MPFD; MYMY5; NEM1; NEM2; NEM3; PS1TP5BP1; SHPM; VSCM
UniProt ID: (Human) P68133, (Bovine) P68138, (Rabbit) P62740, (Chicken) P08023, (Bovine) P62739, (Human) P62736, (Rabbit) P29751, (Bovine) P60712, (Human) P60709, (Chicken) P60706, (Human) P68032, (Bovine) Q3ZC07, (Chicken) P68034, (Human) P63261, (Bovine) P63258, (Chicken) P53478, (Human) P63267, (Bovine) Q5E9B5, (Chicken) P63270
Entrez Gene ID: (Chicken) 421534, (Human) 58, (Bovine) 281592, (Rabbit) 100009506, (Rabbit) 100009271, (Chicken) 423787, (Bovine) 515610, (Human) 59, (Rabbit) 100009272, (Bovine) 280979, (Human) 60, (Chicken) 396526, (Human) 70, (Bovine) 533219, (Chicken) 423298, (Rabbit) 100340339, (Human) 71, (Bovine) 404122, (Chicken) 415296, (Human) 72, (Bovine) 281595, (Rabbit) 100350318, (Chicken) 396084
protein binding
ATP binding
structural constituent of cytoskeleton
myosin binding
ADP binding
protein kinase binding
kinesin binding
Tat protein binding
identical protein binding
nitric-oxide synthase binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
nucleosomal DNA binding
structural constituent of postsynaptic actin cytoskeleton
ATPase activity
ubiquitin protein ligase binding
profilin binding
actin and actin related protein
actin or actin-binding cytoskeletal protein
cytoskeletal protein
skeletal muscle thin filament assembly
skeletal muscle fiber development
muscle contraction
response to mechanical stimulus
response to extracellular stimulus
response to lithium ion
positive regulation of gene expression
cell growth
muscle filament sliding
skeletal muscle fiber adaptation
response to steroid hormone
mesenchyme migration
regulation of blood pressure
response to virus
vascular smooth muscle contraction
glomerular mesangial cell development
morphogenesis of a polarized epithelium
establishment or maintenance of cell polarity
regulation of transmembrane transporter activity
negative regulation of protein binding
adherens junction assembly
apical protein localization
synaptic vesicle endocytosis
regulation of norepinephrine uptake
protein localization to adherens junction
cellular response to cytochalasin B
postsynaptic actin cytoskeleton organization
regulation of protein localization to plasma membrane
retina homeostasis
movement of cell or subcellular component
cytoskeleton organization
substantia nigra development
cell junction assembly
Fc-gamma receptor signaling pathway involved in phagocytosis
ATP-dependent chromatin remodeling
positive regulation of gene expression, epigenetic
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
platelet aggregation
axonogenesis
cell motility
apoptotic process
actin filament-based movement
actomyosin structure organization
actin-myosin filament sliding
response to drug
negative regulation of apoptotic process
response to ethanol
cardiac myofibril assembly
cardiac muscle tissue morphogenesis
heart contraction
cardiac muscle contraction
actin filament organization
sarcomere organization
angiogenesis
positive regulation of cell migration
regulation of stress fiber assembly
regulation of focal adhesion assembly
positive regulation of wound healing
tight junction assembly
protein localization to bicellular tight junction
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