Invitrogen

Adenylate Cyclase 5/6 Polyclonal Antibody

View all (3) Adenylate Cyclase 5/6 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-75274

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acids 1111-1160 of Human ADCY 5
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2719002

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Target Information

Adenylate cyclase 5/6 encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A cyclase V; A cyclase VI; AC5; AC6; ACVI; adcy5; Adenylate cyclase type 5; Adenylate cyclase type 6; Adenylate cyclase type V; Adenylate cyclase type VI; Adenylyl cyclase 5; Adenylyl cyclase 6; adenylyl cyclase type V; ATP pyrophosphate-lyase 5; ATP pyrophosphate-lyase 6; Ca(2+)-inhibitable adenylyl cyclase

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Gene Aliases: AC5; AC6; ACVI; ADCY5; ADCY6; ADCYB; AW121902; FDFM; KIAA0422; LCCS8; mKIAA0422

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UniProt ID: (Human) O95622, (Human) O43306, (Rat) Q04400, (Mouse) P84309, (Rat) Q03343

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Entrez Gene ID: (Human) 111, (Human) 112, (Rat) 64532, (Mouse) 224129, (Rat) 25289, (Mouse) 11512

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Function(s)
adenylate cyclase activity ATP binding adenylate cyclase binding metal ion binding protein heterodimerization activity receptor binding protein binding calcium- and calmodulin-responsive adenylate cyclase activity protein kinase binding nucleotide binding lyase activity phosphorus-oxygen lyase activity scaffold protein binding SNARE binding
Process(es)
adenosine receptor signaling pathway cAMP biosynthetic process adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway adenylate cyclase-inhibiting dopamine receptor signaling pathway locomotory behavior negative regulation of neuron projection development intracellular signal transduction neuromuscular process controlling balance dopamine receptor signaling pathway cellular response to prostaglandin E stimulus cellular response to catecholamine stimulus maintenance of protein location in plasma membrane renal water homeostasis activation of adenylate cyclase activity adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cAMP-mediated signaling activation of protein kinase A activity regulation of insulin secretion involved in cellular response to glucose stimulus cellular response to glucagon stimulus cellular response to forskolin cyclic nucleotide biosynthetic process negative regulation of urine volume regulation of vasodilation cellular response to vasopressin
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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