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Product Details
BS-0611R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Adiponectin receptor 2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR. Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning. AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors are predicted to contain seven transmembrane domains, but are structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adiponectin receptor protein 2; FLJ21432; MGC4640; Progestin and adipoQ receptor family member 2; Progestin and adipoQ receptor family member II
Gene Aliases: 1110001I14Rik; ACDCR2; ADCR2; ADIPOR2; AI115388; AW554121; D6Ucla1e; PAQR2; Parq2
UniProt ID: (Human) Q86V24, (Mouse) Q8BQS5
Entrez Gene ID: (Human) 79602, (Rat) 312670, (Mouse) 68465
G-protein coupled receptor signaling pathway
heart development
female pregnancy
response to nutrient
hormone-mediated signaling pathway
fatty acid oxidation
negative regulation of cell growth
adiponectin-activated signaling pathway
glucose homeostasis
positive regulation of glucose import
vascular wound healing
lipid metabolic process
fatty acid metabolic process
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