Proteintech

Aggrecan Polyclonal Antibody

Aggrecan Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

Aggrecan Antibody (13880-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed A549 cells using 13880-1-AP (Aggrecan antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Aggrecan Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

13880-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 115 publications 115 publications

Immunohistochemistry (IHC)

View 59 publications 59 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 46 publications 46 publications

Miscellaneous PubMed (Misc)

View 5 publications 5 publications

Not applicable (N/A)

View 7 publications 7 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rabbit, Rat, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Aggrecan Fusion Protein Ag4985 (1-298 aa encoded by BC036445)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This polyclonal antibody raised against 1-298 aa of human aggrecan reveals a band of 70 kDa, which is consistent with the molecular weight of degradation product generated by proteolysis at the aggrecanase site.

Immunogen sequence: MTTLLWVFV TLRVITAAVT VETSDHDNSL SVSIPQPSPL RVLLGTSLTI PCYFIDPMHP VTTAPSTAPL APRIKWSRVS KEKEVVLLVA TEGRVRVNSA YQDKVSLPNY PAIPSDATLE VQSLRSNDSG VYRCEVMHGI EDSEATLEVV VKGIVFHYRA ISTRYTLDFD RAQRACLQNS AIIATPEQLQ AAYEDGFHQC DAGWLADQTV RYPIHTPREG CYGDKDEFPG VRTYGIRDTN ETYDVYCFAE EMEGEVFYAT SPEKFTFQEA ANECRRLGAR LATTGQLYLA WQAGMDMCS (1-298 aa encoded by BC036445 )

Target Information

Aggrecan also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1 is a protein that is encoded by the ACAN gene. The encoded protein is an integral part of the extracellular matrix in cartilaginous tissue and it withstands compression in cartilage. The human form of the protein is 2316 amino acids long (approximately 250 kDa) and can be expressed in multiple isoforms due to alternative splicing. Aggrecan exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate chains are attached to an extended protein core. The synthesis and degradation of aggrecan are being investigated for their roles in cartilage deterioration during joint injury, disease, and aging. It contains three interglobular domains (IGDs), G1, G2, and G3 that are involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis. Aggrecan fragments from articular cartilage are released into the synovial fluid at all stages of human osteoarthritis as a result of cleavage by aggrecanase and MMP activity. Antibodies BC-3 and BC-4 can be used to detect these neo epitopes of Aggrecanase (ARGSVXXX) and MMP (XXXVDIPEN), respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.

Experimental & molecular medicine

Wang J,Xia D,Lin Y,Xu W,Wu Y,Chen J,Chu J,Shen P,Weng S,Wang X,Shen L,Fan S,Shen S

Tue Mar 01 00:00:00 EST 2022

Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy.

Journal of nanobiotechnology

Yang L,Yu C,Fan X,Zeng T,Yang W,Xia J,Wang J,Yao L,Hu C,Jin Y,Zhu Y,Chen J,Hu Z

Sat Oct 01 00:00:00 EDT 2022

Bioprinted living tissue constructs with layer-specific, growth factor-loaded microspheres for improved enthesis healing of a rotator cuff.

Acta biomaterialia

Bai L,Han Q,Meng Z,Chen B,Qu X,Xu M,Su Y,Qiu Z,Xue Y,He J,Zhang J,Yin Z

Thu Dec 01 00:00:00 EST 2022

Bioprinted living tissue constructs with layer-specific, growth factor-loaded microspheres for improved enthesis healing of a rotator cuff.

Acta biomaterialia

Bai L,Han Q,Meng Z,Chen B,Qu X,Xu M,Su Y,Qiu Z,Xue Y,He J,Zhang J,Yin Z

Thu Dec 01 00:00:00 EST 2022

3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy.

Frontiers in pharmacology

Tang H,Qin K,Wang A,Li S,Fang S,Gao W,Lu M,Huang W,Zhang H,Yin Z

Tue Nov 29 00:00:00 EST 2022

3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy.

Frontiers in pharmacology

Tang H,Qin K,Wang A,Li S,Fang S,Gao W,Lu M,Huang W,Zhang H,Yin Z

Tue Nov 29 00:00:00 EST 2022

Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.

Journal of orthopaedic surgery (Hong Kong)

Zhang C,Li Z,Li L,Li S,Yang L,Chen L,Zhang X,Yang S,Guo Y

Tue Nov 01 00:00:00 EDT 2022

Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.

Oxidative medicine and cellular longevity

Chen J,Cui Z,Wang Y,Lyu L,Feng C,Feng D,Cheng Y,Li Z,Sun S

Thu Mar 24 00:00:00 EDT 2022

Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.

Biochemical pharmacology

Ni L,Lin Z,Hu S,Shi Y,Jiang Z,Zhao J,Zhou Y,Wu Y,Tian N,Sun L,Wu A,Pan Z,Zhang X,Wang X

Fri Apr 01 00:00:00 EDT 2022

Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.

Journal of nanobiotechnology

Liao Z,Ke W,Liu H,Tong B,Wang K,Feng X,Hua W,Wang B,Song Y,Luo R,Liang H,Zhang W,Zhao K,Li S,Yang C

Mon Sep 19 00:00:00 EDT 2022

Phenotypic and functional properties of dedifferentiated fat cells derived from infrapatellar fat pad.

Regenerative therapy

Tanimoto K,Matsumoto T,Nagaoka Y,Kazama T,Yamamoto C,Kano K,Nagaoka M,Saito S,Tokuhashi Y,Nakanishi K

Tue Mar 01 00:00:00 EST 2022

MCP‑1/CCR2 axis inhibits the chondrogenic differentiation of human nucleus pulposus mesenchymal stem cells.

Molecular medicine reports

Ou X,Wen T,Ying J,He Q,Xuan A,Ruan D

Thu Sep 01 00:00:00 EDT 2022

MiR-1260b protects against LPS-induced degenerative changes in nucleus pulposus cells through targeting TCF7L2.

Human cell

Chen S,Shi G,Zeng J,Li PH,Peng Y,Ding Z,Cao HQ,Zheng R,Wang W

Sun May 01 00:00:00 EDT 2022

MiR-1260b protects against LPS-induced degenerative changes in nucleus pulposus cells through targeting TCF7L2.

Human cell

Chen S,Shi G,Zeng J,Li PH,Peng Y,Ding Z,Cao HQ,Zheng R,Wang W

Sun May 01 00:00:00 EDT 2022

Nanosilicate-Reinforced Silk Fibroin Hydrogel for Endogenous Regeneration of Both Cartilage and Subchondral Bone.

Advanced healthcare materials

Sheng R,Chen J,Wang H,Luo Y,Liu J,Chen Z,Mo Q,Chi J,Ling C,Tan X,Yao Q,Zhang W

Thu Sep 01 00:00:00 EDT 2022

Nanosilicate-Reinforced Silk Fibroin Hydrogel for Endogenous Regeneration of Both Cartilage and Subchondral Bone.

Advanced healthcare materials

Sheng R,Chen J,Wang H,Luo Y,Liu J,Chen Z,Mo Q,Chi J,Ling C,Tan X,Yao Q,Zhang W

Thu Sep 01 00:00:00 EDT 2022

A three-dimensional (3D), serum-free, Collagen Type I system for chondrogenesis of canine bone marrow-derived multipotent stromal cells (cMSCs).

PloS one

MacIver MA,Dobson LK,Gregory CA,Muneoka K,Saunders WB

Mon Jun 13 00:00:00 EDT 2022

Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.

Cellular signalling

Dai WY,Luo ZP

Tue Mar 01 00:00:00 EST 2022

Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.

Cellular signalling

Dai WY,Luo ZP

Tue Mar 01 00:00:00 EST 2022

Scutellarin Protects Against Mitochondrial Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation to Attenuate Intervertebral Disc Degeneration.

Frontiers in bioengineering and biotechnology

Wang Z,Zhang P,Zhao Y,Yu F,Wang S,Liu K,Cheng X,Shi J,He Q,Xia Y,Cheng L

Tue Aug 30 00:00:00 EDT 2022

Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis.

Drug design, development and therapy

Han H,Chen M,Li Z,Zhou S,Wu Y,Wei J

Tue Aug 16 00:00:00 EDT 2022

Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.

Bioengineered

Zhu W,Tang H,Li J,Guedes RM,Cao L,Guo C

Fri Apr 01 00:00:00 EDT 2022

Exosomes derived from hypoxia preconditioned mesenchymal stem cells laden in a silk hydrogel promote cartilage regeneration via the miR-205-5p/PTEN/AKT pathway.

Acta biomaterialia

Shen K,Duan A,Cheng J,Yuan T,Zhou J,Song H,Chen Z,Wan B,Liu J,Zhang X,Zhang Y,Xie R,Liu F,Fan W,Zuo Q

Fri Apr 15 00:00:00 EDT 2022

Hyaluronic Acid Oligosaccharide Derivatives Alleviate Lipopolysaccharide-Induced Inflammation in ATDC5 Cells by Multiple Mechanisms.

Molecules (Basel, Switzerland)

Huang H,Ding X,Xing D,Lin J,Li Z,Lin J

Wed Aug 31 00:00:00 EDT 2022

The anti-inflammation effect of strontium ranelate on rat chondrocytes with or without IL-1β in vitro.

Experimental and therapeutic medicine

Yu H,Liu Y,Yang X,He J,Zhong Q,Guo X

Tue Mar 01 00:00:00 EST 2022

USP14 promotes pyroptosis of human annulus fibrosus cells derived from patients with intervertebral disc degeneration through deubiquitination of NLRP3.

Acta biochimica et biophysica Sinica

Hai B,Mao T,Du C,Jia F,Liu Y,Song Q,Pan X,Liu X,Zhu B

Fri Nov 25 00:00:00 EST 2022

Extracellular vesicles derived from mesenchymal stem cells confer protection against intervertebral disc degeneration through a microRNA-217-dependent mechanism.

Osteoarthritis and cartilage

Hao Y,Zhu G,Yu L,Ren Z,Zhang P,Zhu J,Cao S

Tue Nov 01 00:00:00 EDT 2022

Extracellular vesicles derived from mesenchymal stem cells confer protection against intervertebral disc degeneration through a microRNA-217-dependent mechanism.

Osteoarthritis and cartilage

Hao Y,Zhu G,Yu L,Ren Z,Zhang P,Zhu J,Cao S

Tue Nov 01 00:00:00 EDT 2022

CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy.

Acta pharmacologica Sinica

Dong J,Zhang KJ,Li GC,Chen XR,Lin JJ,Li JW,Lv ZY,Deng ZZ,Dai J,Cao W,Jiang Q

Fri Jul 01 00:00:00 EDT 2022

PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells.

Frontiers in cell and developmental biology

Zhang Z,Huang Y,Xu N,Wang J,Yao T,Xu Y,Qiao D,Gao J,Shen S,Ma J

Tue Apr 05 00:00:00 EDT 2022

PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells.

Frontiers in cell and developmental biology

Zhang Z,Huang Y,Xu N,Wang J,Yao T,Xu Y,Qiao D,Gao J,Shen S,Ma J

Tue Apr 05 00:00:00 EDT 2022

An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration.

International journal of molecular sciences

Cheng H,Guo Q,Zhao H,Liu K,Kang H,Gao F,Guo J,Yuan X,Hu S,Li F,Yang Q,Fang Z

Mon Dec 26 00:00:00 EST 2022

Glucocorticoid caused lactic acid accumulation and damage in human chondrocytes via ROS-mediated inhibition of Monocarboxylate Transporter 4.

Bone

Li Q,Chen H,Li Z,Zhang F,Chen L

Tue Feb 01 00:00:00 EST 2022

Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.

Rheumatology (Oxford, England)

Liu L,Zhao C,Zhang H,Lu Y,Luo B,Yao Z,Shao Y,Zeng H,Zeng C,Zhang R,Fang H,Pan J,Bai X,Cai D

Mon May 30 00:00:00 EDT 2022

Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.

Rheumatology (Oxford, England)

Liu L,Zhao C,Zhang H,Lu Y,Luo B,Yao Z,Shao Y,Zeng H,Zeng C,Zhang R,Fang H,Pan J,Bai X,Cai D

Mon May 30 00:00:00 EDT 2022

Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.

Rheumatology (Oxford, England)

Liu L,Zhao C,Zhang H,Lu Y,Luo B,Yao Z,Shao Y,Zeng H,Zeng C,Zhang R,Fang H,Pan J,Bai X,Cai D

Mon May 30 00:00:00 EDT 2022

Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.

Rheumatology (Oxford, England)

Liu L,Zhao C,Zhang H,Lu Y,Luo B,Yao Z,Shao Y,Zeng H,Zeng C,Zhang R,Fang H,Pan J,Bai X,Cai D

Mon May 30 00:00:00 EDT 2022

Zoledronate promotes ECM degradation and apoptosis via Wnt/β-catenin.

Open medicine (Warsaw, Poland)

Xiao J,Li Y,Cheng G,Xu G

Sat Jul 16 00:00:00 EDT 2022

Hedgehog Signalling Contributes to Trauma-Induced Tendon Heterotopic Ossification and Regulates Osteogenesis through Antioxidant Pathway in Tendon-Derived Stem Cells.

Antioxidants (Basel, Switzerland)

Li G,Deng Y,Li K,Liu Y,Wang L,Wu Z,Chen C,Zhang K,Yu B

Wed Nov 16 00:00:00 EST 2022

Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage.

Stem cell research & therapy

Zhou H,Shen X,Yan C,Xiong W,Ma Z,Tan Z,Wang J,Li Y,Liu J,Duan A,Liu F

Sat Jul 16 00:00:00 EDT 2022

Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage.

Stem cell research & therapy

Zhou H,Shen X,Yan C,Xiong W,Ma Z,Tan Z,Wang J,Li Y,Liu J,Duan A,Liu F

Sat Jul 16 00:00:00 EDT 2022

DDIT3/CHOP mediates the inhibitory effect of ER stress on chondrocyte differentiation by AMPKα-SIRT1 pathway.

Biochimica et biophysica acta. Molecular cell research

Yu X,Xu X,Dong W,Yang C,Luo Y,He Y,Jiang C,Wu Y,Wang J

Mon Aug 01 00:00:00 EDT 2022

A protocol to induce expandable limb-bud mesenchymal cells from human pluripotent stem cells.

STAR protocols

Takao T,Yamada D,Takarada T

Fri Dec 16 00:00:00 EST 2022

Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells.

BMC pharmacology & toxicology

Chen W,Yasen M,Wang H,Zhuang C,Wang Z,Lu S,Jiang L,Lin H

Thu Dec 01 00:00:00 EST 2022

LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.

Orthopaedic surgery

Yi Y,Yang N,Yang Z,Tao X,Li Y

Tue Nov 01 00:00:00 EDT 2022

LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.

Orthopaedic surgery

Yi Y,Yang N,Yang Z,Tao X,Li Y

Tue Nov 01 00:00:00 EDT 2022

LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.

Orthopaedic surgery

Yi Y,Yang N,Yang Z,Tao X,Li Y

Tue Nov 01 00:00:00 EDT 2022

LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.

Orthopaedic surgery

Yi Y,Yang N,Yang Z,Tao X,Li Y

Tue Nov 01 00:00:00 EDT 2022

A Photoannealed Granular Hydrogel Facilitating Hyaline Cartilage Regeneration via Improving Chondrogenic Phenotype.

ACS applied materials & interfaces

Zhu Y,Sun Y,Rui B,Lin J,Shen J,Xiao H,Liu X,Chai Y,Xu J,Yang Y

Wed Sep 14 00:00:00 EDT 2022

A Photoannealed Granular Hydrogel Facilitating Hyaline Cartilage Regeneration via Improving Chondrogenic Phenotype.

ACS applied materials & interfaces

Zhu Y,Sun Y,Rui B,Lin J,Shen J,Xiao H,Liu X,Chai Y,Xu J,Yang Y

Wed Sep 14 00:00:00 EDT 2022

Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-181c-5p Promote BMP2-Induced Repair of Cartilage Injury through Inhibition of SMAD7 Expression.

Stem cells international

Zhang Q,Cao L,Zou S,Feng Y,Miao X,Huang L,Wu Y

Sat Jul 16 00:00:00 EDT 2022

Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-181c-5p Promote BMP2-Induced Repair of Cartilage Injury through Inhibition of SMAD7 Expression.

Stem cells international

Zhang Q,Cao L,Zou S,Feng Y,Miao X,Huang L,Wu Y

Sat Jul 16 00:00:00 EDT 2022

Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-181c-5p Promote BMP2-Induced Repair of Cartilage Injury through Inhibition of SMAD7 Expression.

Stem cells international

Zhang Q,Cao L,Zou S,Feng Y,Miao X,Huang L,Wu Y

Sat Jul 16 00:00:00 EDT 2022

Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-181c-5p Promote BMP2-Induced Repair of Cartilage Injury through Inhibition of SMAD7 Expression.

Stem cells international

Zhang Q,Cao L,Zou S,Feng Y,Miao X,Huang L,Wu Y

Sat Jul 16 00:00:00 EDT 2022

RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss.

EMBO reports

Hu Y,Li X,Zhi X,Cong W,Huang B,Chen H,Wang Y,Li Y,Wang L,Fang C,Guo J,Liu Y,Cui J,Cao L,Weng W,Zhou Q,Wang S,Chen X,Su J

Mon Jul 05 00:00:00 EDT 2021

AKAP2 overexpression modulates growth plate chondrocyte functions through ERK1/2 signaling.

Bone

Wang B,Jiang B,Li Y,Dai Y,Li P,Li L,Xu J,Li L,Wu P

Sat May 01 00:00:00 EDT 2021

In the presence of TGF-β1, Asperosaponin VI promotes human mesenchymal stem cell differentiation into nucleus pulposus like- cells.

BMC complementary medicine and therapies

Niu YT,Xie L,Deng RR,Zhang XY

Thu Jan 14 00:00:00 EST 2021

Genetic association scan of 32 osteoarthritis susceptibility genes identified TP63 associated with an endemic osteoarthritis, Kashin-Beck disease.

Bone

Cheng B,Liang C,Yang X,Li P,Liu L,Cheng S,Jia Y,Zhang L,Ma M,Qi X,Yao Y,Chu X,Ye J,Lu C,Guo X,Wen Y,Zhang F

Wed Sep 01 00:00:00 EDT 2021

Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.

Frontiers in pharmacology

Zhou H,Li G,Wang Y,Jiang R,Li Y,Wang H,Wang F,Ma H,Cao L

Wed Apr 28 00:00:00 EDT 2021

Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.

Frontiers in pharmacology

Zhou H,Li G,Wang Y,Jiang R,Li Y,Wang H,Wang F,Ma H,Cao L

Wed Apr 28 00:00:00 EDT 2021

Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy.

BioMed research international

Zhang S,Liang W,Abulizi Y,Xu T,Cao R,Xun C,Zhang J,Sheng W

Mon Sep 20 00:00:00 EDT 2021

Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy.

BioMed research international

Zhang S,Liang W,Abulizi Y,Xu T,Cao R,Xun C,Zhang J,Sheng W

Mon Sep 20 00:00:00 EDT 2021

USP7 regulates the proliferation and differentiation of ATDC5 cells through the Sox9-PTHrP-PTH1R axis.

Bone

Dong X,Xu X,Yang C,Luo Y,Wu Y,Wang J

Mon Feb 01 00:00:00 EST 2021

Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model.

Stem cell research & therapy

Duan A,Shen K,Li B,Li C,Zhou H,Kong R,Shao Y,Qin J,Yuan T,Ji J,Guo W,Wang X,Xue T,Li L,Huang X,Sun Y,Cai Z,Liu W,Liu F

Wed Jul 28 00:00:00 EDT 2021

Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model.

Stem cell research & therapy

Duan A,Shen K,Li B,Li C,Zhou H,Kong R,Shao Y,Qin J,Yuan T,Ji J,Guo W,Wang X,Xue T,Li L,Huang X,Sun Y,Cai Z,Liu W,Liu F

Wed Jul 28 00:00:00 EDT 2021

MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.

Cell death & disease

Lu Y,Liu L,Pan J,Luo B,Zeng H,Shao Y,Zhang H,Guan H,Guo D,Zeng C,Zhang R,Bai X,Zhang H,Cai D

Tue May 25 00:00:00 EDT 2021

M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration.

Frontiers in immunology

Li L,Wei K,Ding Y,Ahati P,Xu H,Fang H,Wang H

Thu Oct 14 00:00:00 EDT 2021

Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway.

Cartilage

Shen PC,Chou SH,Lu CC,Huang HT,Chien SH,Huang PJ,Liu ZM,Shih CL,Su SJ,Chen LM,Tien YC

Wed Dec 01 00:00:00 EST 2021

HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.

Autophagy

He R,Wang Z,Cui M,Liu S,Wu W,Chen M,Wu Y,Qu Y,Lin H,Chen S,Wang B,Shao Z

Mon Nov 01 00:00:00 EDT 2021

Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual.

Stem cell research & therapy

Sun J,Xing F,Zou M,Gong M,Li L,Xiang Z

Mon Jun 28 00:00:00 EDT 2021

The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.

Frontiers in pharmacology

Yu Y,Liu X,Zhao Z,Xu Z,Qiao Y,Zhou Y,Qiao H,Zhong J,Dai J,Suo G

Fri Dec 24 00:00:00 EST 2021

SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.

Stem cells and development

Ding N,Zeng MY,Song WJ,Xiao CX,Li EM,Wei B

Fri Oct 15 00:00:00 EDT 2021

Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.

Ecotoxicology and environmental safety

Yu FF,Zuo J,Fu X,Gao MH,Sun L,Yu SY,Li Z,Zhou GY,Ba Y

Wed Dec 01 00:00:00 EST 2021

Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.

Cartilage

Lei J,Deng H,Ran Y,Lv Y,Amhare AF,Wang L,Guo X,Han J,Lammi MJ

Wed Dec 01 00:00:00 EST 2021

Fatty acid sensing GPCR (GPR84) signaling safeguards cartilage homeostasis and protects against osteoarthritis.

Pharmacological research

Wang F,Ma L,Ding Y,He L,Chang M,Shan Y,Siwko S,Chen G,Liu Y,Jin Y,Peng X,Luo J

Mon Feb 01 00:00:00 EST 2021

Fatty acid sensing GPCR (GPR84) signaling safeguards cartilage homeostasis and protects against osteoarthritis.

Pharmacological research

Wang F,Ma L,Ding Y,He L,Chang M,Shan Y,Siwko S,Chen G,Liu Y,Jin Y,Peng X,Luo J

Mon Feb 01 00:00:00 EST 2021

NFKB2 inhibits NRG1 transcription to affect nucleus pulposus cell degeneration and inflammation in intervertebral disc degeneration.

Mechanisms of ageing and development

Wang X,Wu H,Zhang Q,Liu F,Wang J,Wei C,Liu F,Li J

Thu Jul 01 00:00:00 EDT 2021

Involvement of Transient Receptor Potential Vanilloid Channel 2 in the Induction of Lubricin and Suppression of Ectopic Endochondral Ossification in Mouse Articular Cartilage.

Arthritis & rheumatology (Hoboken, N.J.)

Nakamoto H,Katanosaka Y,Chijimatsu R,Mori D,Xuan F,Yano F,Omata Y,Maenohara Y,Murahashi Y,Kawaguchi K,Yamagami R,Inui H,Taketomi S,Taniguchi Y,Kanagawa M,Naruse K,Tanaka S,Saito T

Sun Aug 01 00:00:00 EDT 2021

The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.

Frontiers in bioscience (Landmark edition)

Gao XX,Liu CH,Hu ZL,Li HY,Chang X,Li YY,Zhang YY,Zhai Y,Li CQ

Sat Oct 30 00:00:00 EDT 2021

Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.

Frontiers in pharmacology

Lu R,Yu X,Liang S,Cheng P,Wang Z,He ZY,Lv ZT,Wan J,Mo H,Zhu WT,Chen AM

Tue Dec 21 00:00:00 EST 2021

Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.

Frontiers in pharmacology

Lu R,Yu X,Liang S,Cheng P,Wang Z,He ZY,Lv ZT,Wan J,Mo H,Zhu WT,Chen AM

Tue Dec 21 00:00:00 EST 2021

Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.

Frontiers in pharmacology

Lu R,Yu X,Liang S,Cheng P,Wang Z,He ZY,Lv ZT,Wan J,Mo H,Zhu WT,Chen AM

Tue Dec 21 00:00:00 EST 2021

Overloading stress-induced progressive degeneration and self-repair in condylar cartilage.

Annals of the New York Academy of Sciences

Fang L,Ye Y,Tan X,Huang L,He Y

Mon Nov 01 00:00:00 EDT 2021

ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.

Aging

Ding J,Zhang R,Li H,Ji Q,Cheng X,Thorne RF,Hondermarck H,Liu X,Shen C

Tue Apr 06 00:00:00 EDT 2021

Hyaluronic acid hydrogel encapsulated BMP-14-modified ADSCs accelerate cartilage defect repair in rabbits.

Journal of orthopaedic surgery and research

Liu H,Rui Y,Liu J,Gao F,Jin Y

Wed Nov 03 00:00:00 EDT 2021

The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence.

Mechanisms of ageing and development

Zhong H,Zhou Z,Guo L,Liu F,Zheng B,Bi S,Tian C

Mon Mar 01 00:00:00 EST 2021

The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence.

Mechanisms of ageing and development

Zhong H,Zhou Z,Guo L,Liu F,Zheng B,Bi S,Tian C

Mon Mar 01 00:00:00 EST 2021

microRNA-129-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates intervertebral disc degeneration via blockade of LRG1-mediated p38 MAPK activation.

Journal of tissue engineering

Cui S,Zhang L

Thu Aug 12 00:00:00 EDT 2021

microRNA-129-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates intervertebral disc degeneration via blockade of LRG1-mediated p38 MAPK activation.

Journal of tissue engineering

Cui S,Zhang L

Thu Aug 12 00:00:00 EDT 2021

Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes.

Frontiers in cell and developmental biology

Luo L,Gong J,Zhang H,Qin J,Li C,Zhang J,Tang Y,Zhang Y,Chen J,Zhou Y,Tian Z,Liu Y,Liu M

Tue Mar 23 00:00:00 EDT 2021

A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway.

Theranostics