Invitrogen

Angiopoietin 1 Recombinant Rabbit Monoclonal Antibody (SN67-02)

View all (28) Angiopoietin 1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-32279

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SN67-02

Immunogen

Synthetic peptide within Human Angiopoietin 1 aa 249-300
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2809565

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ANG-1; Angiopoietin-1

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Gene Aliases: 1110046O21Rik; AGP1; AGPT; Agpt1; Ang-1; ANG1; ANGPT1; KIAA0003

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UniProt ID: (Human) Q15389, (Mouse) O08538, (Rat) O35460

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Entrez Gene ID: (Human) 284, (Mouse) 11600, (Rat) 89807

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Function(s)
Ras guanyl-nucleotide exchange factor activity receptor tyrosine kinase binding receptor binding vascular endothelial growth factor receptor binding molecular_function intercellular signal molecule
Process(es)
MAPK cascade in utero embryonic development negative regulation of protein phosphorylation regulation of endothelial cell proliferation sprouting angiogenesis positive regulation of receptor internalization negative regulation of cytokine secretion involved in immune response negative regulation of cell adhesion activation of transmembrane receptor protein tyrosine kinase activity positive regulation of endothelial cell migration positive regulation of phosphatidylinositol 3-kinase signaling regulation of skeletal muscle satellite cell proliferation hemopoiesis cell differentiation heparin biosynthetic process positive regulation of protein ubiquitination cell-substrate adhesion regulation of tumor necrosis factor production positive regulation of peptidyl-serine phosphorylation protein localization to cell surface negative regulation of protein import into nucleus negative regulation of apoptotic process negative regulation of vascular permeability regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein binding negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration positive regulation of GTPase activity positive regulation of cell adhesion Tie signaling pathway positive regulation of peptidyl-tyrosine phosphorylation leukocyte migration positive chemotaxis positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade glomerulus vasculature development negative regulation of endothelial cell apoptotic process regulation of macrophage migration inhibitory factor signaling pathway angiogenesis ovarian follicle development patterning of blood vessels vasculogenesis endocardium morphogenesis transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development endoderm development positive regulation of vascular endothelial growth factor receptor signaling pathway protein homooligomerization cardiac muscle tissue morphogenesis vasculogenesis involved in coronary vascular morphogenesis response to hypoxia organ regeneration response to vitamin B3 response to estrogen
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