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Angiopoietin 4 Antibody (PA5-121388) in WB
Western Blot analysis of Angiopoietin 4 using Angiopoietin 4 Polyclonal Antibody (Product # PA5-121388). Positive WB detected in: Mouse heart tissue, Mouse kidney tissue. All lanes: Angiopoietin 4 antibody at 1:2,000. Secondary. Goat polyclonal to rabbit IgG at 1/50,000 dilution. Predicted band size: 57 kDa. Observed band size: 57 kDa.
Product Details
PA5-121388
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Mouse Angiogenin-4 protein (25-144aa)
Conjugate
Form
Liquid
Concentration
2.94 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2914960
Product Specific Information
Antibody tested in Indirect ELISA
Target Information
Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2, a cell surface receptor tyrosine kinase expressed in endothelial and hemopoietic cells. Ang-1 is an angiogenic factor that mediates blood vessel maturation and may be involved in endothelial development. A related protein, angiopoietin-2 (Ang-2), is a naturally occurring antagonist of Ang-1 activation of Tie-2. In adult tissue, Ang-2 expression is restricted to sites of vascular remodeling. Ang-3 and Ang-4 represent the mouse and human counterparts of the same gene locus. The structural divergence of Ang-3 and Ang-4 cause their divergent functions. Ang-3 and Ang-4 have very different distributions in their respective species, and Ang-3 appears to act as an antagonist while Ang-4 appears to function as an agonist. Ang-3 and Ang-4 share all the main structural characteristics of Ang-1 and Ang-2 and are homologous throughout the signal peptide, N-terminal region, coiled-coil segment and Fibrinogen-like domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AGP4; ANG-3; ANG-4; angiopoietin 3; Angiopoietin-3; Angiopoietin-4; Angiopoietin3; Angiopoietin4
Gene Aliases: Agpt4; Ang3; Angpt4
UniProt ID: (Mouse) Q9WVH6
Entrez Gene ID: (Mouse) 11602
angiogenesis
activation of transmembrane receptor protein tyrosine kinase activity
Notch signaling pathway
endoderm development
positive regulation of endothelial cell migration
negative regulation of angiogenesis
negative regulation of apoptotic process
positive regulation of blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration
positive regulation of angiogenesis
Tie signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein tyrosine kinase activity
positive regulation of receptor activity
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