Proteintech

Angiotensinogen Polyclonal Antibody

Angiotensinogen Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Angiotensinogen Antibody (11992-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human liver tissue slide using (Product # 11992-1-AP) Angiotensinogen antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Angiotensinogen Antibody in Western Blot (WB)

Angiotensinogen Antibody in Flow Cytometry (Flow)

Product Image Gallery

Product Details

11992-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Product Specifications

Species Reactivity

Human

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Angiotensinogen Fusion Protein Ag2632 (136-485 aa encoded by BC011519)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: PTAVFGTLA SLYLGALDHT ADRLQAILGV PWKDKNCTSR LDAHKVLSAL QAVQGLLVAQ GRADSQAQLL LSTVVGVFTA PGLHLKQPFV QGLALYTPVV LPRSLDFTEL DVAAEKIDRF MQAVTGWKTG CSLTGASVDS TLAFNTYVHF QGKMKGFSLL AEPQEFWVDN STSVSVPMLS GMGTFQHWSD IQDNFSVTQV SFTESACLLL IQPHYASDLD KVEGLTFQQN SLNWMKKLSP RTIHLTMPQL VLQGSYDLQD LLAQAELPAI LHTELNLQKL SNDRIRVGEV LNSIFFELEA DEREPTESTQ QLNKPEVLEV TLNRPFLFAV YDQSATALHF LGRVANPLST A (136-485 aa encoded by BC011519)

Target Information

The protein encoded by AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Mon May 01 00:00:00 EDT 2023

The Key Role of Initiation Timing on Stroke Rehabilitation by Remote Ischemic Conditioning with Exercise (RICE).

Neurological research

Wang Q,Wehbe A,Wills M,Li F,Geng X,Ding Y

Sat Apr 01 00:00:00 EDT 2023

System Analysis Based on Lipid-Metabolism-Related Genes Identifies AGT as a Novel Therapy Target for Gastric Cancer with Neoadjuvant Chemotherapy.

Pharmaceutics

Zhu L,Ma M,Zhang L,Wang S,Guo Y,Ling X,Lin H,Lai N,Lin S,Du L,Dong Q

Thu Mar 02 00:00:00 EST 2023

Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity.

BMC cancer

Gao X,Jiang P,Wei X,Zhang W,Zheng J,Sun S,Yao H,Liu X,Zhang Q

Wed Feb 15 00:00:00 EST 2023

Intrarenal renin-angiotensin system activation and macrophage infiltrations in pediatric chronic glomerulonephritis.

Pediatric nephrology (Berlin, Germany)

Hattori T,Fujioka K,Nagai T,Kondo S,Kagami S,Hirayama M,Urushihara M

Wed Nov 01 00:00:00 EDT 2023

Intrarenal renin-angiotensin system activation and macrophage infiltrations in pediatric chronic glomerulonephritis.

Pediatric nephrology (Berlin, Germany)

Hattori T,Fujioka K,Nagai T,Kondo S,Kagami S,Hirayama M,Urushihara M

Wed Nov 01 00:00:00 EDT 2023

Proteome-wide and matrisome-specific atlas of the human ovary computes fertility biomarker candidates and open the way for precision oncofertility.

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Ouni E,Nedbal V,Da Pian M,Cao H,Haas KT,Peaucelle A,Van Kerk O,Herinckx G,Marbaix E,Dolmans MM,Tuuri T,Otala M,Amorim CA,Vertommen D

Sun May 01 00:00:00 EDT 2022

Fuyuan Xingnao Decoction Promotes Angiogenesis Through the Rab1/AT1R Pathway in Diabetes Mellitus Complicated With Cerebral Infarction.

Frontiers in pharmacology

Deng D,Qu Y,Sun L,Jia L,Bu J,Ye M,Chen Z,Geng Y,Zhou S,Fang B

Wed Mar 10 00:00:00 EST 2021

Protective effect of recombinant Lactobacillus plantarum against H₂O₂-induced oxidative stress in HUVEC cells.

Journal of Zhejiang University. Science. B

Wang G,Hao M,Liu Q,Jiang Y,Huang H,Yang G,Wang C

Sat May 15 00:00:00 EDT 2021

AGT serves as a potential biomarker and drives tumor progression in colorectal carcinoma.

International immunopharmacology

Chen W,Chen Y,Zhang K,Yang W,Li X,Zhao J,Liu K,Dong Z,Lu J

Wed Dec 01 00:00:00 EST 2021

AGT serves as a potential biomarker and drives tumor progression in colorectal carcinoma.

International immunopharmacology

Chen W,Chen Y,Zhang K,Yang W,Li X,Zhao J,Liu K,Dong Z,Lu J

Wed Dec 01 00:00:00 EST 2021

Effect of Hydrocortisone on Angiotensinogen (AGT) Mutation-Causing Autosomal Recessive Renal Tubular Dysgenesis.

Cells

Tseng MH,Huang SM,Konrad M,Huang JL,Shaw SW,Tian YC,Chueh HY,Fan WL,Wu TW,Ding JJ,Chiang MC,Lin SH

Thu Apr 01 00:00:00 EDT 2021

Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Xiao Y,Deng J,Li C,Gong X,Gui Z,Huang J,Zhang Y,Liu Y,Ye X,Li X

Mon Mar 01 00:00:00 EST 2021

Downregulation of spinal angiotensin converting enzyme 2 is involved in neuropathic pain associated with type 2 diabetes mellitus in mice.

Biochemical pharmacology

Yamagata R,Nemoto W,Nakagawasai O,Takahashi K,Tan-No K

Wed Apr 01 00:00:00 EDT 2020

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Kankala RK,Zhao J,Liu CG,Song XJ,Yang DY,Zhu K,Wang SB,Zhang YS,Chen AZ

Sat Jun 01 00:00:00 EDT 2019

Expression of Renin-Angiotensin System Components in the Taste Organ of Mice.

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Shigemura N,Takai S,Hirose F,Yoshida R,Sanematsu K,Ninomiya Y

Thu Sep 19 00:00:00 EDT 2019

ALDH2 protects against alcoholic cardiomyopathy through a mechanism involving the p38 MAPK/CREB pathway and local renin-angiotensin system inhibition in cardiomyocytes.

International journal of cardiology

Liu B,Zhang R,Wei S,Yuan Q,Xue M,Hao P,Xu F,Wang J,Chen Y

Sun Apr 15 00:00:00 EDT 2018

ALDH2 protects against alcoholic cardiomyopathy through a mechanism involving the p38 MAPK/CREB pathway and local renin-angiotensin system inhibition in cardiomyocytes.

International journal of cardiology

Liu B,Zhang R,Wei S,Yuan Q,Xue M,Hao P,Xu F,Wang J,Chen Y

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Scientific reports

Guo H,Wang Y,Zhang X,Zang Y,Zhang Y,Wang L,Wang H,Wang Y,Cao A,Peng W

Mon Jul 31 00:00:00 EDT 2017

Astragaloside IV protects against podocyte injury via SERCA2-dependent ER stress reduction and AMPKα-regulated autophagy induction in streptozotocin-induced diabetic nephropathy.

Scientific reports

Guo H,Wang Y,Zhang X,Zang Y,Zhang Y,Wang L,Wang H,Wang Y,Cao A,Peng W

Mon Jul 31 00:00:00 EDT 2017

Involvement of Spinal Angiotensin II System in Streptozotocin-Induced Diabetic Neuropathic Pain in Mice.

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Ogata Y,Nemoto W,Nakagawasai O,Yamagata R,Tadano T,Tan-No K

Thu Sep 01 00:00:00 EDT 2016

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Molecular pharmacology

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Mechanical stretch induces angiotensinogen expression through PARP1 activation in kidney proximal tubular cells.

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Thu Jan 01 00:00:00 EST 2015

Mechanical stretch induces angiotensinogen expression through PARP1 activation in kidney proximal tubular cells.

In vitro cellular & developmental biology. Animal

Lee JS,Lim JY,Kim J

Thu Jan 01 00:00:00 EST 2015

Attenuation of brain damage and cognitive impairment by direct renin inhibition in mice with chronic cerebral hypoperfusion.

Hypertension (Dallas, Tex. : 1979)

Dong YF,Kataoka K,Toyama K,Sueta D,Koibuchi N,Yamamoto E,Yata K,Tomimoto H,Ogawa H,Kim-Mitsuyama S

Sat Oct 01 00:00:00 EDT 2011

Attenuation of brain damage and cognitive impairment by direct renin inhibition in mice with chronic cerebral hypoperfusion.

Hypertension (Dallas, Tex. : 1979)

Dong YF,Kataoka K,Toyama K,Sueta D,Koibuchi N,Yamamoto E,Yata K,Tomimoto H,Ogawa H,Kim-Mitsuyama S

Sat Oct 01 00:00:00 EDT 2011

Bioinformatics

Protein Aliases: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; Angiotensinogen; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; Serpin A8; serpin peptidase inhibitor, clade A, member 8

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Gene Aliases: AGT; ANHU; SERPINA8

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UniProt ID: (Human) P01019

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Entrez Gene ID: (Human) 183

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Function(s)

serine-type endopeptidase inhibitor activity hormone activity protein binding growth factor activity type 1 angiotensin receptor binding type 2 angiotensin receptor binding protease inhibitor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Angiotensinogen Polyclonal Antibody

Angiotensinogen Antibody (11992-1-AP) in IHC (P)

Product Details

11992-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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