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Ankyrin G Antibody (PA5-143560) in ICC/IF
Immunofluorescent analysis of Ankyrin G in cortical neuron-glial cell culture from E20 rat. Samples were stained with Ankyrin G polyclonal antibody (Product # PA5-143560) using a dilution of 1:2,000 (green). Costained with mouse mAb to FOX3/NeuN, dilution 1:2,000 in red. The blue is Hoechst staining of nuclear DNA. The ankyrin G antibody stains the axonal initial segments, while the FOX3/NeuN antibody revea... View More
Product Details
PA5-143560
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Chicken
/ IgY
Class
Polyclonal
Type
Antibody
Immunogen
The C-terminal 398 amino acids of human ankyrin 3 expressed in and purified from E. coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
5mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2942789
Target Information
Ankyrin-G is found in several tissues including brain where, due to tissue-specific RNA processing, it is expressed as two different isoforms, localized to axon initial segments and nodes of Ranvier. Ankyrin-G is also found at sites of epithelial cell-cell contact and in the intracellular membranes of some cells. Ankyrin-G isoforms contain a unique stretch of sequence highly enriched in serine and threonine residues immediately following a globular head domain. Ankyrin-G is thought to participate in the maintenance and targeting of ion channels and cell adhesion molecules to the nodes of Ranvier and to axon initial segments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANK-3; ankyrin 3 (G); ankyrin 3, epithelial; ankyrin 3, node of Ranvier (ankyrin G); Ankyrin-3; Ankyrin-G; brain-specific ankyrin-G
Gene Aliases: 2900054D09Rik; AI314020; ANK-3; ANK3; AnkG; Ankyrin-3; ANKYRIN-G; MRT37
UniProt ID: (Human) Q12955, (Rat) O70511, (Mouse) G5E8K5
Entrez Gene ID: (Bovine) 511203, (Human) 288, (Rat) 361833, (Mouse) 11735
mitotic cytokinesis
ER to Golgi vesicle-mediated transport
plasma membrane organization
cytoskeletal anchoring at plasma membrane
signal transduction
axonogenesis
axon guidance
neuromuscular junction development
positive regulation of gene expression
positive regulation of cell communication by electrical coupling
positive regulation of sodium ion transport
magnesium ion homeostasis
neuronal action potential
positive regulation of homotypic cell-cell adhesion
Golgi to plasma membrane protein transport
regulation of potassium ion transport
establishment of protein localization
positive regulation of membrane potential
cellular response to magnesium ion
membrane assembly
protein localization to plasma membrane
maintenance of protein location in plasma membrane
protein targeting to plasma membrane
positive regulation of protein targeting to membrane
positive regulation of membrane depolarization during cardiac muscle cell action potential
negative regulation of delayed rectifier potassium channel activity
positive regulation of sodium ion transmembrane transporter activity
positive regulation of cation channel activity
synapse organization
positive regulation of action potential
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