Proteintech

Annexin A1 Polyclonal Antibody

Annexin A1 Antibody in Immunocytochemistry (ICC/IF)

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Annexin A1 Antibody (21990-1-AP) in ICC/IF

Immunofluorescent analysis of A431 cells using 21990-1-AP (Annexin A1 antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Annexin A1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Annexin A1 Antibody in Western Blot (WB)

Annexin A1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

21990-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 21 publications 21 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:20-1:200

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 4 publications 4 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Annexin A1 Fusion Protein Ag17273 (1-346 aa encoded by BC001275)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAMVSEFLK QAWFIENEEQ EYVQTVKSSK GGPGSAVSPY PTFNPSSDVA ALHKAIMVKG VDEATIIDIL TKRNNAQRQQ IKAAYLQETG KPLDETLKKA LTGHLEEVVL ALLKTPAQFD ADELRAAMKG LGTDEDTLIE ILASRTNKEI RDINRVYREE LKRDLAKDIT SDTSGDFRNA LLSLAKGDRS EDFGVNEDLA DSDARALYEA GERRKGTDVN VFNTILTTRS YPQLRRVFQK YTKYSKHDMN KVLDLELKGD IEKCLTAIVK CATSKPAFFA EKLHQAMKGV GTRHKALIRI MVSRSEIDMN DIKAFYQKMY GISLCQAILD ETKGDYEKIL VALCGGN (1-346 aa encoded by BC001275)

Target Information

Annexin I belongs to a family of Ca (2+) -dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. Annexin I has a molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Development of a Novel Circulating Autoantibody Biomarker Panel for the Identification of Patients with 'Actionable' Pulmonary Nodules.

Cancers

Auger C,Moudgalya H,Neely MR,Stephan JT,Tarhoni I,Gerard D,Basu S,Fhied CL,Abdelkader A,Vargas M,Hu S,Hulett T,Liptay MJ,Shah P,Seder CW,Borgia JA

Wed Apr 12 00:00:00 EDT 2023

Annexin A1 induces oxaliplatin resistance of gastric cancer through autophagy by targeting PI3K/AKT/mTOR.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ren J,Hu Z,Niu G,Xia J,Wang X,Hong R,Gu J,Wang D,Ke C

Wed Mar 01 00:00:00 EST 2023

Annexin A1 induces oxaliplatin resistance of gastric cancer through autophagy by targeting PI3K/AKT/mTOR.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ren J,Hu Z,Niu G,Xia J,Wang X,Hong R,Gu J,Wang D,Ke C

Wed Mar 01 00:00:00 EST 2023

Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis.

Nature communications

Fankhaenel M,Hashemi FSG,Mourao L,Lucas E,Hosawi MM,Skipp P,Morin X,Scheele CLGJ,Elias S

Wed Jan 11 00:00:00 EST 2023

The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis.

Oncogene

Wang Y,Peng M,Zhong Y,Xiong W,Zhu L,Jin X

Wed Mar 01 00:00:00 EST 2023

Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.

Inflammation

Zhu M,Wang Y,Zhu L,Du S,Wang Z,Zhang Y,Guo Y,Tu Y,Song E

Tue Feb 01 00:00:00 EST 2022

YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway.

Journal of experimental & clinical cancer research : CR

Li W,Ye K,Li X,Liu X,Peng M,Chen F,Xiong W,Wang Y,Zhu L

Wed Aug 17 00:00:00 EDT 2022

Circulating PD-L1 is associated with T cell infiltration and predicts prognosis in patients with CRLM following hepatic resection.

Cancer immunology, immunotherapy : CII

Chen X,Du Z,Huang M,Wang D,Fong WP,Liang J,Fan L,Wang Y,Yang H,Chen Z,Hu M,Xu R,Li Y

Tue Mar 01 00:00:00 EST 2022

ANXA1: An Important Independent Prognostic Factor and Molecular Target in Glioma.

Frontiers in genetics

Zhang D,Wang W,Zhou H,Su L,Han X,Zhang X,Han W,Wang Y,Xue X

Sat Jul 16 00:00:00 EDT 2022

Reassessment of the Proteomic Composition and Function of Extracellular Vesicles in the Seminal Plasma.

Endocrinology

Wang H,Zhu Y,Tang C,Zhou Z,Wang Z,Li Z,Zheng X,Chen S,Zhou Y,Liang A,Li Y,Lin Y,Sun F

Sat Jan 01 00:00:00 EST 2022

Recruitment of DNA to tumor-derived microvesicles.

Cell reports

Clancy JW,Sheehan CS,Boomgarden AC,D'Souza-Schorey C

Tue Mar 01 00:00:00 EST 2022

Recruitment of DNA to tumor-derived microvesicles.

Cell reports

Clancy JW,Sheehan CS,Boomgarden AC,D'Souza-Schorey C

Tue Mar 01 00:00:00 EST 2022

Global mapping of Salmonella enterica-host protein-protein interactions during infection.

Cell host & microbe

Walch P,Selkrig J,Knodler LA,Rettel M,Stein F,Fernandez K,Viéitez C,Potel CM,Scholzen K,Geyer M,Rottner K,Steele-Mortimer O,Savitski MM,Holden DW,Typas A

Wed Aug 11 00:00:00 EDT 2021

Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease.

American journal of physiology. Gastrointestinal and liver physiology

Girish N,Liu CY,Gadeock S,Gomez ML,Huang Y,Sharifkhodaei Z,Washington MK,Polk DB

Wed Sep 01 00:00:00 EDT 2021

Exosomal annexin A6 induces gemcitabine resistance by inhibiting ubiquitination and degradation of EGFR in triple-negative breast cancer.

Cell death & disease

Li T,Tao Z,Zhu Y,Liu X,Wang L,Du Y,Cao J,Wang B,Zhang J,Hu X

Thu Jul 08 00:00:00 EDT 2021

EphB2 activates CREB-dependent expression of Annexin A1 to regulate dendritic spine morphogenesis.

Biochemical and biophysical research communications

Yuan L,Yi W,Sun C,Ma S,Wang J,Liu S,Chen Y,Chen Y,Chen Y

Mon Dec 20 00:00:00 EST 2021

ANXA1 affects murine hair follicle growth through EGF signaling pathway.

Gene

Zhang H,Fu X,Ao Y,Nan M,Qiu Z,Jia X,Xiao Y,Liu D,Guo X

Mon Mar 01 00:00:00 EST 2021

ANXA1 affects murine hair follicle growth through EGF signaling pathway.

Gene

Zhang H,Fu X,Ao Y,Nan M,Qiu Z,Jia X,Xiao Y,Liu D,Guo X

Mon Mar 01 00:00:00 EST 2021

Annexin A1 Attenuates Neutrophil Migration and IL-6 Expression through Fpr2 in a Mouse Model of Streptococcus suis-Induced Meningitis.

Infection and immunity

Ni C,Gao S,Zheng Y,Liu P,Zhai Y,Huang W,Jiang H,Lv Q,Kong D,Jiang Y

Tue Feb 16 00:00:00 EST 2021

WISP1 promotes bovine MDSC differentiation via recruitment of ANXA1 for the regulation of the TGF-β signalling pathway.

Molecular and cellular biochemistry

Zhang C,Zhang Y,Zhang W,Tong H,Li S,Yan Y

Wed Jul 01 00:00:00 EDT 2020

WISP1 promotes bovine MDSC differentiation via recruitment of ANXA1 for the regulation of the TGF-β signalling pathway.

Molecular and cellular biochemistry

Zhang C,Zhang Y,Zhang W,Tong H,Li S,Yan Y

Wed Jul 01 00:00:00 EDT 2020

WISP1 promotes bovine MDSC differentiation via recruitment of ANXA1 for the regulation of the TGF-β signalling pathway.

Molecular and cellular biochemistry

Zhang C,Zhang Y,Zhang W,Tong H,Li S,Yan Y

Wed Jul 01 00:00:00 EDT 2020

ER-luminal [Ca²⁺] regulation of InsP₃ receptor gating mediated by an ER-luminal peripheral Ca²⁺-binding protein.

eLife

Vais H,Wang M,Mallilankaraman K,Payne R,McKennan C,Lock JT,Spruce LA,Fiest C,Chan MY,Parker I,Seeholzer SH,Foskett JK,Mak DD

Mon May 18 00:00:00 EDT 2020

ER-luminal [Ca²⁺] regulation of InsP₃ receptor gating mediated by an ER-luminal peripheral Ca²⁺-binding protein.

eLife

Vais H,Wang M,Mallilankaraman K,Payne R,McKennan C,Lock JT,Spruce LA,Fiest C,Chan MY,Parker I,Seeholzer SH,Foskett JK,Mak DD

Mon May 18 00:00:00 EDT 2020

ER-luminal [Ca²⁺] regulation of InsP₃ receptor gating mediated by an ER-luminal peripheral Ca²⁺-binding protein.

eLife

Vais H,Wang M,Mallilankaraman K,Payne R,McKennan C,Lock JT,Spruce LA,Fiest C,Chan MY,Parker I,Seeholzer SH,Foskett JK,Mak DD

Mon May 18 00:00:00 EDT 2020

ER-luminal [Ca²⁺] regulation of InsP₃ receptor gating mediated by an ER-luminal peripheral Ca²⁺-binding protein.

eLife

Vais H,Wang M,Mallilankaraman K,Payne R,McKennan C,Lock JT,Spruce LA,Fiest C,Chan MY,Parker I,Seeholzer SH,Foskett JK,Mak DD

Mon May 18 00:00:00 EDT 2020

TCEA3 promotes differentiation of C2C12 cells via an Annexin A1-mediated transforming growth factor-β signaling pathway.

Journal of cellular physiology