Invitrogen

Annexin A1 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.

1 Published Figure
1 Reference
View all (76) Annexin A1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-22266

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:20,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Rabbit

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fragment corresponding to a region within amino acids 1 and 228 of Annexin A1 (Uniprot ID#P04083)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_11153240

Product Specific Information

Recommended positive controls: H1299, NIH-3T3, HeLa.

Predicted reactivity: Mouse (86%), Rat (89%), Dog (92%), Cat (93%), Pig (87%), Rabbit (92%), Chimpanzee (99%), Bovine (89%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Annexin I belongs to a family of Ca (2+) -dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. Annexin I has a molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ANAX1; Annexin A1; Annexin I; annexin I (lipocortin I); Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; lipocortin 1; Lipocortin I; p35; Phospholipase A2 inhibitory protein; RP11-71A24.1

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Gene Aliases: Anx-1; Anx-A1; ANX1; ANXA1; C430014K04Rik; Lpc-1; LPC1

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UniProt ID: (Human) P04083, (Mouse) P10107

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Entrez Gene ID: (Human) 301, (Mouse) 16952

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Function(s)
single-stranded DNA binding single-stranded RNA binding helicase activity receptor binding structural molecule activity calcium ion binding protein binding phospholipid binding calcium-dependent phospholipid binding phospholipase A2 inhibitor activity protein binding, bridging double-stranded DNA-dependent ATPase activity annealing helicase activity protein homodimerization activity calcium-dependent protein binding cadherin binding involved in cell-cell adhesion phospholipase inhibitor activity calcium-binding protein
Process(es)
DNA strand renaturation neutrophil homeostasis adaptive immune response monocyte chemotaxis regulation of leukocyte migration phagocytosis inflammatory response signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger regulation of cell shape response to X-ray myoblast migration involved in skeletal muscle regeneration peptide cross-linking insulin secretion keratinocyte differentiation prostate gland development endocrine pancreas development positive regulation of vesicle fusion positive regulation of prostaglandin biosynthetic process actin cytoskeleton reorganization response to estradiol DNA duplex unwinding regulation of interleukin-1 production positive regulation of interleukin-2 production positive regulation of neutrophil apoptotic process DNA rewinding gliogenesis positive regulation of T cell proliferation response to drug negative regulation of apoptotic process response to peptide hormone estrous cycle innate immune response positive regulation of T-helper 1 cell differentiation negative regulation of T-helper 2 cell differentiation negative regulation of exocytosis alpha-beta T cell differentiation regulation of hormone secretion arachidonic acid secretion regulation of inflammatory response cellular response to hydrogen peroxide hepatocyte differentiation prolactin secretion response to interleukin-1 cellular response to glucocorticoid stimulus granulocyte chemotaxis positive regulation of wound healing neutrophil clearance positive regulation of G1/S transition of mitotic cell cycle negative regulation of phospholipase A2 activity negative regulation of interleukin-8 secretion regulation of cell proliferation positive regulation of apoptotic process negative regulation of protein secretion
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