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Annexin A1 Antibody (MA5-49198) in IHC (P)
Immunohistochemistry analysis of Annexin A1 in paraffin-embedded section of human lung squamous cell carcinoma tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. Samples were incubated with Annexin A1 Monoclonal antibody (Product # MA5-49198) using a dilution of 2 μg/mL overnight at 4°C. Peroxidase Co... View More
Product Details
MA5-49198
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
6B7F8
Immunogen
E.coli-derived human Annexin A1 recombinant protein (Position: A2-N346).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3074856
Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Human Annexin A1 shares 88% and 89% amino acid (aa) sequence identity with mouse and rat Annexin A1, respectively.
Target Information
Annexin I belongs to a family of Ca (2+) -dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. Annexin I has a molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANAX1; Annexin A1; Annexin I; annexin I (lipocortin I); Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; p35; Phospholipase A2 inhibitory protein; RP11-71A24.1
Gene Aliases: ANX1; ANXA1; LPC1
UniProt ID: (Human) P04083
Entrez Gene ID: (Human) 301
single-stranded DNA binding
single-stranded RNA binding
helicase activity
receptor binding
structural molecule activity
calcium ion binding
protein binding
phospholipid binding
calcium-dependent phospholipid binding
phospholipase A2 inhibitor activity
protein binding, bridging
double-stranded DNA-dependent ATPase activity
annealing helicase activity
protein homodimerization activity
calcium-dependent protein binding
cadherin binding involved in cell-cell adhesion
calcium-binding protein
DNA strand renaturation
neutrophil homeostasis
adaptive immune response
monocyte chemotaxis
regulation of leukocyte migration
phagocytosis
inflammatory response
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of cell shape
response to X-ray
myoblast migration involved in skeletal muscle regeneration
peptide cross-linking
insulin secretion
keratinocyte differentiation
prostate gland development
endocrine pancreas development
positive regulation of vesicle fusion
positive regulation of prostaglandin biosynthetic process
actin cytoskeleton reorganization
response to estradiol
DNA duplex unwinding
regulation of interleukin-1 production
positive regulation of interleukin-2 production
positive regulation of neutrophil apoptotic process
DNA rewinding
gliogenesis
positive regulation of T cell proliferation
response to drug
negative regulation of apoptotic process
response to peptide hormone
estrous cycle
innate immune response
positive regulation of T-helper 1 cell differentiation
negative regulation of T-helper 2 cell differentiation
negative regulation of exocytosis
alpha-beta T cell differentiation
regulation of hormone secretion
arachidonic acid secretion
regulation of inflammatory response
cellular response to hydrogen peroxide
hepatocyte differentiation
prolactin secretion
response to interleukin-1
cellular response to glucocorticoid stimulus
granulocyte chemotaxis
positive regulation of wound healing
neutrophil clearance
positive regulation of G1/S transition of mitotic cell cycle
negative regulation of phospholipase A2 activity
negative regulation of interleukin-8 secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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