Proteintech

Antizyme inhibitor 1 Polyclonal Antibody

Antizyme inhibitor 1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 13

Antizyme inhibitor 1 Antibody (11548-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using AZIN1 antibody 11548-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

Antizyme inhibitor 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Antizyme inhibitor 1 Antibody in Western Blot (WB)

Product Image Gallery

Product Details

11548-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Antizyme inhibitor 1 Fusion Protein Ag2082 (149-448 aa encoded by BC019279)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: AKVLLHIAT EDNIGGEEGN MKFGTTLKNC RHLLECAKEL DVQIIGVKFH VSSACKESQV YVHALSDARC VFDMAGEIGF TMNMLDIGGG FTGTEFQLEE VNHVISPLLD IYFPEGSGVK IISEPGSYYV SSAFTLAVNI IAKKVVENDK FPSGVEKTGS DEPAFMYYMN DGVYGSFASK LSEDLNTIPE VHKKYKEDEP LFTSSLWGPS CDELDQIVES CLLPELNVGD WLIFDNMGAD SFHEPSAFND FQRPAIYYMM SFSDWYEMQD AGITSDSMMK NFFFVPSCIQ LSQEDSFSAE A (149-448 aa encoded by BC019279)

Target Information

Antizyme inhibitor (AZIN1) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing.

The Journal of biological chemistry

Xing Y,Nakahama T,Wu Y,Inoue M,Kim JI,Todo H,Shibuya T,Kato Y,Kawahara Y

Sat Jul 01 00:00:00 EDT 2023

AZIN1 RNA editing alters protein interactions, leading to nuclear translocation and worse outcomes in prostate cancer.

Experimental & molecular medicine

Ghalali A,Wang L,Stopsack KH,Rice JM,Wu S,Wu CL,Zetter BR,Rogers MS

Sat Oct 01 00:00:00 EDT 2022

Targeting RNA editing of antizyme inhibitor 1: A potential oligonucleotide-based antisense therapy for cancer.

Molecular therapy : the journal of the American Society of Gene Therapy

Tay DJT,Song Y,Peng B,Toh TB,Hooi L,Toh DK,Hong H,Tang SJ,Han J,Gan WL,Chan THM,Krishna MS,Patil KM,Maraswami M,Loh TP,Dan YY,Zhou L,Bonney GK,Chow PK,Chen G,Chow EK,Le MTN,Chen L

Wed Nov 03 00:00:00 EDT 2021

The rational discovery of multipurpose inhibitors of the ornithine decarboxylase.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chai X,Zhan J,Pan J,He M,Li B,Wang J,Ma H,Wang Y,Liu S

Tue Sep 01 00:00:00 EDT 2020

Upregulation of Circular RNA CircNFIB Attenuates Cardiac Fibrosis by Sponging miR-433.

Frontiers in genetics

Zhu Y,Pan W,Yang T,Meng X,Jiang Z,Tao L,Wang L

Thu Oct 01 00:00:00 EDT 2020

Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.

The Journal of clinical investigation

Bianchi-Smiraglia A,Bagati A,Fink EE,Affronti HC,Lipchick BC,Moparthy S,Long MD,Rosario SR,Lightman SM,Moparthy K,Wolff DW,Yun DH,Han Z,Polechetti A,Roll MV,Gitlin II,Leonova KI,Rowsam AM,Kandel ES,Gudkov AV,Bergsagel PL,Lee KP,Smiraglia DJ,Nikiforov MA

Mon Oct 01 00:00:00 EDT 2018

Pancreatic Kininogenase Ameliorates Renal Fibrosis in Streptozotocin Induced-Diabetic Nephropathy Rat.

Kidney & blood pressure research

Zhu D,Zhang L,Cheng L,Ren L,Tang J,Sun D

Tue Dec 13 00:00:00 EST 2016

Pancreatic Kininogenase Ameliorates Renal Fibrosis in Streptozotocin Induced-Diabetic Nephropathy Rat.

Kidney & blood pressure research

Zhu D,Zhang L,Cheng L,Ren L,Tang J,Sun D

Tue Dec 13 00:00:00 EST 2016

Crucial Role of miR-433 in Regulating Cardiac Fibrosis.

Theranostics

Tao L,Bei Y,Chen P,Lei Z,Fu S,Zhang H,Xu J,Che L,Chen X,Sluijter JP,Das S,Cretoiu D,Xu B,Zhong J,Xiao J,Li X

Mon Oct 16 00:00:00 EDT 2017

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.

Cancer cell

Han L,Diao L,Yu S,Xu X,Li J,Zhang R,Yang Y,Werner HMJ,Eterovic AK,Yuan Y,Li J,Nair N,Minelli R,Tsang YH,Cheung LWT,Jeong KJ,Roszik J,Ju Z,Woodman SE,Lu Y,Scott KL,Li JB,Mills GB,Liang H

Mon Oct 12 00:00:00 EDT 2015

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.

Cancer cell

Han L,Diao L,Yu S,Xu X,Li J,Zhang R,Yang Y,Werner HMJ,Eterovic AK,Yuan Y,Li J,Nair N,Minelli R,Tsang YH,Cheung LWT,Jeong KJ,Roszik J,Ju Z,Woodman SE,Lu Y,Scott KL,Li JB,Mills GB,Liang H

Mon Oct 12 00:00:00 EDT 2015

The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathway.

Kidney international

Li R,Chung AC,Dong Y,Yang W,Zhong X,Lan HY

Sun Dec 01 00:00:00 EST 2013

The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathway.

Kidney international

Li R,Chung AC,Dong Y,Yang W,Zhong X,Lan HY

Sun Dec 01 00:00:00 EST 2013

The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathway.

Kidney international

Li R,Chung AC,Dong Y,Yang W,Zhong X,Lan HY

Sun Dec 01 00:00:00 EST 2013

The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathway.

Kidney international

Li R,Chung AC,Dong Y,Yang W,Zhong X,Lan HY

Sun Dec 01 00:00:00 EST 2013

Bioinformatics

Protein Aliases: Antizyme inhibitor 1; AZI; O OAZIN; ODC antizyme inhibitor; Ornithine decarboxylase antizyme inhibitor

View more View less

Gene Aliases: 1700085L02Rik; AZI; AZIA1; AZIN1; OAZI; OAZIN; ODC1L

View more View less

UniProt ID: (Human) O14977, (Mouse) O35484

View more View less

Entrez Gene ID: (Human) 51582, (Rat) 58961, (Mouse) 54375

View more View less

Function(s)

catalytic activity protein binding ornithine decarboxylase activator activity ornithine decarboxylase inhibitor activity decarboxylase

Process(es)

regulation of cellular amino acid metabolic process putrescine biosynthetic process from ornithine negative regulation of protein catabolic process positive regulation of catalytic activity positive regulation of polyamine transmembrane transport polyamine biosynthetic process negative regulation of catalytic activity polyamine metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

Antizyme inhibitor 1 Polyclonal Antibody

Antizyme inhibitor 1 Antibody (11548-1-AP) in ICC/IF

Product Details

11548-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!