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Ataxin 7 Antibody (BS-11318R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Rat brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with Ataxin 7 Polyclonal Antibody, Unconjugated (bs-11318R) at 1:200 overnight at 4°C, DAB staining.
Product Details
BS-11318R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Ataxin 7, amino acids 301-400.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Spinocerebellar ataxia type 7 (SCA7) belongs to a class of hereditary neurodegenrative diseases characterized by abnormally expanded polyglutamine (CAG) repeats at the N-terminus. This autosomal dominant cerebellar ataxia primarily affects the cerebellum, retina, and brain stem and causes dementia, macular degeneration and other neurodegenerative characteristics. SCA7 gene encodes the ubiquitous 892 residue protein ataxin-7. This protein is typically located in the cytoplasm and on the nuclear membrane of normal brain neurons. In cells where there is a mutation of the SCA7 gene, ataxin 7 accumulates in intranuclear inclusions and can result in cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ataxin 7; Ataxin-7; spinocerebellar ataxia 7 homolog; Spinocerebellar ataxia type 7 protein; Spinocerebellar ataxia type 7 protein homolog
Gene Aliases: A430107N12Rik; ADCAII; AI627028; ataxin-7; ATXN7; OPCA3; RGD1562692; SCA7
UniProt ID: (Human) O15265, (Mouse) Q8R4I1
Entrez Gene ID: (Human) 6314, (Mouse) 246103, (Rat) 361015
microtubule cytoskeleton organization
transcription, DNA-templated
regulation of transcription, DNA-templated
histone deubiquitination
negative regulation of phosphorylation
negative regulation of insulin-like growth factor receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
biological_process
nucleus organization
visual perception
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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