Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen.
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Protein Aliases: ARK-1; AURAK; Aurora 2; aurora A; Aurora A Kinase; aurora family kinase 1; Aurora kinase A; aurora-A; aurora-related kinase 1; aurora/IP; Aurora/IPL1-related kinase 1; AURORA2; EC 2.7.11.1; hARK1; Ipl1- and aurora-related kinase 1; IPL1-related kinase; MGC34538; OTTHUMP00000031341; OTTHUMP00000166072; ratAurA; RP5-1167H4.6; serine/threonine kinase 6; serine/threonine protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase Ayk1
Gene Aliases: Aik; AIRK1; ARK-1; Ark1; AU019385; Aura; Aurka; Aurora-A; AW539821; Ayk1; Btak; IAK; IAK1; Stk15; Stk6
UniProt ID: (Mouse) P97477
Entrez Gene ID: (Mouse) 20878, (Rat) 261730
Molecular Function:
non-receptor serine/threonine protein kinase
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