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Product Details
PA5-52743
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human B4GALT1. Recombinant protein control fragment (Product #RP-90001).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2638438
Product Specific Information
Immunogen sequence: FRGMSISRPN AVVGRCRMIR HSRDKKNEPN PQRFDRIAHT KETMLSDGLN SLTYQVLDVQ RYPLYTQITV DIGTPS
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 91%.
Target Information
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beta-1,4-galactosyltransferase 1; Beta-1,4-GalTase 1; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; glycoprotein-4-beta-galactosyltransferase 2; Golgi complex; lactose synthase; Lactose synthase A protein; N-acetyllactosamine synthase; Nal synthase; Neolactotriaosylceramide beta-1,4-galactosyltransferase; Processed beta-1; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
Gene Aliases: B4GAL-T1; B4GALT1; beta4Gal-T1; CDG2D; GGTB2; GT1; GTB
UniProt ID: (Human) P15291
Entrez Gene ID: (Human) 2683
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
N-acetyllactosamine synthase activity
lactose synthase activity
cytoskeletal protein binding
galactosyltransferase activity
protein kinase binding
manganese ion binding
UDP-galactosyltransferase activity
glycosyltransferase
epithelial cell development
acute inflammatory response
lactose biosynthetic process
galactose metabolic process
protein N-linked glycosylation
cell adhesion
binding of sperm to zona pellucida
penetration of zona pellucida
negative regulation of cell proliferation
oligosaccharide biosynthetic process
keratan sulfate biosynthetic process
extracellular matrix organization
mammary gland development
development of secondary sexual characteristics
branching morphogenesis of an epithelial tube
leukocyte migration
regulation of cellular component movement
regulation of acrosome reaction
positive regulation of epithelial cell proliferation involved in wound healing
angiogenesis involved in wound healing
positive regulation of apoptotic process involved in mammary gland involution
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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