Proteintech

BACE1 Polyclonal Antibody

BACE1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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BACE1 Antibody (12807-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using 12807-1-AP (BACE1 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

BACE1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12807-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 29 publications 29 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat, Zebrafish

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BACE1 Fusion Protein Ag3559 (157-457 aa encoded by BC036084)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VRANIAAIT ESDKFFINGS NWEGILGLAY AEIARPDDSL EPFFDSLVKQ THVPNLFSLQ LCGAGFPLNQ SEVLASVGGS MIIGGIDHSL YTGSLWYTPI RREWYYEVII VRVEINGQDL KMDCKEYNYD KSIVDSGTTN LRLPKKVFEA AVKSIKAASS TEKFPDGFWL GEQLVCWQAG TTPWNIFPVI SLYLMGEVTN QSFRITILPQ QYLRPVEDVA TSQDDCYKFA ISQSSTGTVM GAVIMEGFYV VFDRARKRIG FAVSACHVHD EFRTAAVEGP FVTLDMEDCG YNIPQTDEST LM (157-457 aa encoded by BC036084)

Target Information

BACE1 (beta-secretase) is a key enzyme involved in the production of amyloid beta-peptides (Abeta) found in extracellular amyloid plaques of Alzheimer's disease (AD). In some cases early onset familial AD can be attributed to a "Swedish" mutation in the amyloid precursor protein (APP), which dramatically enhances the cleavage of this protein by BACE1. This and other genetic and pathological evidence has led to therapeutic approaches that have focused on the inhibition of BACE1 and other APP-cleaving enzymes, such as gamma-secretase stuff. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer's disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). bACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Mon May 01 00:00:00 EDT 2023

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Tue Aug 01 00:00:00 EDT 2023

Ginsenoside ompound K reduces neuronal damage and improves neuronal synaptic dysfunction by targeting Aβ.

Frontiers in pharmacology

Li N,Pang Q,Zhang Y,Lin J,Li H,Li Z,Liu Y,Fang X,An Y,Bai H,Li D,Cao Z,Liu J,Yang Q,Hu S

Tue Mar 07 00:00:00 EST 2023

Ginsenoside ompound K reduces neuronal damage and improves neuronal synaptic dysfunction by targeting Aβ.

Frontiers in pharmacology

Li N,Pang Q,Zhang Y,Lin J,Li H,Li Z,Liu Y,Fang X,An Y,Bai H,Li D,Cao Z,Liu J,Yang Q,Hu S

Tue Mar 07 00:00:00 EST 2023

Therapeutic effects of total saikosaponins from Radix bupleuri against Alzheimer's disease.

Frontiers in pharmacology

Li J,Zou B,Cheng XY,Yang XH,Li J,Zhao CH,Ma RX,Tian JX,Yao Y

Tue Aug 09 00:00:00 EDT 2022

Targeting Aβ and p-Tau Clearance in Methamphetamine-Induced Alzheimer's Disease-Like Pathology: Roles of Syntaxin 17 in Autophagic Degradation in Primary Hippocampal Neurons.

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Thu Jun 02 00:00:00 EDT 2022

Targeting Aβ and p-Tau Clearance in Methamphetamine-Induced Alzheimer's Disease-Like Pathology: Roles of Syntaxin 17 in Autophagic Degradation in Primary Hippocampal Neurons.

Oxidative medicine and cellular longevity

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Thu Jun 02 00:00:00 EDT 2022

Brain-Penetration and Neuron-Targeting DNA Nanoflowers Co-Delivering miR-124 and Rutin for Synergistic Therapy of Alzheimer's Disease.

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Fri Apr 01 00:00:00 EDT 2022

Thiamine insufficiency induces Hypoxia Inducible Factor-1α as an upstream mediator for neurotoxicity and AD-like pathology.

Molecular and cellular neurosciences

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Thu Dec 01 00:00:00 EST 2022

Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.

Neuroscience letters

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Sat Sep 25 00:00:00 EDT 2021

Modified Low-Temperature Extraction Method for Isolation of Bletilla striata Polysaccharide as Antioxidant for the Prevention of Alzheimer's Disease.

International journal of molecular sciences

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Thu Nov 25 00:00:00 EST 2021

Modified Low-Temperature Extraction Method for Isolation of Bletilla striata Polysaccharide as Antioxidant for the Prevention of Alzheimer's Disease.

International journal of molecular sciences

Lin YW,Fang CH,Liang YJ,Liao HH,Lin FH

Thu Nov 25 00:00:00 EST 2021

N-linoleyltyrosine exerts neuroprotective effects in APP/PS1 transgenic mice via cannabinoid receptor-mediated autophagy.

Journal of pharmacological sciences

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Wed Dec 01 00:00:00 EST 2021

N-linoleyltyrosine exerts neuroprotective effects in APP/PS1 transgenic mice via cannabinoid receptor-mediated autophagy.

Journal of pharmacological sciences

Long CM,Zheng QX,Zhou Y,Liu YT,Gong LP,Zeng YC,Liu S

Wed Dec 01 00:00:00 EST 2021

Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation.

Neurochemistry international

Xu Y,Dong Y,Wang C,Jiang Q,Chu H,Tian Y

Wed Sep 01 00:00:00 EDT 2021

Bone marrow mesenchymal stem cells-derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway.

Cell biology international

Wang X,Yang G

Thu Apr 01 00:00:00 EDT 2021

Activating transcription factor 6 reduces Aβ1-42 and restores memory in Alzheimer's disease model mice.

The International journal of neuroscience

Du Y,Liu X,Zhu X,Liu Y,Wang X,Wu X

Thu Oct 01 00:00:00 EDT 2020

Effect of Moxibustion on Behavioral Changes and Expression of APP and BACE1 in Hippocampus of SAMP8 Mice.

Evidence-based complementary and alternative medicine : eCAM

Ha L,Yang B,Wang S,An Y,Wang H,Cui Y

Sat Apr 16 00:00:00 EDT 2022

Effect of Moxibustion on Behavioral Changes and Expression of APP and BACE1 in Hippocampus of SAMP8 Mice.

Evidence-based complementary and alternative medicine : eCAM

Ha L,Yang B,Wang S,An Y,Wang H,Cui Y

Sat Apr 16 00:00:00 EDT 2022

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Thu Sep 17 00:00:00 EDT 2020

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Frontiers in cellular neuroscience

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Thu Aug 01 00:00:00 EDT 2019

Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting.

Neuroscience bulletin

Zhang Y,Xie JZ,Xu XY,Hu J,Xu T,Jin S,Yang SJ,Wang JZ

Thu Aug 01 00:00:00 EDT 2019

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Brain research

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Wed Apr 17 00:00:00 EDT 2019

Effects of chain length of saturated fatty acids on Aβ generation in SH-SY5Y cells.

Neuroscience letters

Liu JJ,Zhang W,Wang SS,Jia ZQ,Shi YH,Yang L,Shi RL

Wed Apr 17 00:00:00 EDT 2019

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Journal of molecular neuroscience : MN

Yang Q,Lin J,Zhang H,Liu Y,Kan M,Xiu Z,Chen X,Lan X,Li X,Shi X,Li N,Qu X

Tue Jan 01 00:00:00 EST 2019

Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.

Journal of molecular neuroscience : MN

Yang Q,Lin J,Zhang H,Liu Y,Kan M,Xiu Z,Chen X,Lan X,Li X,Shi X,Li N,Qu X

Tue Jan 01 00:00:00 EST 2019

Memantine, a Noncompetitive N-Methyl-D-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression.

Molecular neurobiology

Inoue Y,Ueda M,Masuda T,Misumi Y,Yamashita T,Ando Y

Sun Dec 01 00:00:00 EST 2019

p35 Hemizygous Deletion in 5xFAD Mice Increases Aβ Plaque Load in Males but Not in Females.

Neuroscience

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Tue Oct 01 00:00:00 EDT 2019

Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease.

Antioxidants & redox signaling

Zhao YS,Zhang LH,Yu PP,Gou YJ,Zhao J,You LH,Wang ZY,Zheng X,Yan LJ,Yu P,Chang YZ

Thu May 10 00:00:00 EDT 2018

Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease.

Antioxidants & redox signaling

Zhao YS,Zhang LH,Yu PP,Gou YJ,Zhao J,You LH,Wang ZY,Zheng X,Yan LJ,Yu P,Chang YZ

Thu May 10 00:00:00 EDT 2018

Geniposide attenuates Aβ_25-35-induced neurotoxicity via the TLR4/NF-κB pathway in HT22 cells.

RSC advances

Huang XF,Li JJ,Tao YG,Wang XQ,Zhang RL,Zhang JL,Su ZQ,Huang QH,Deng YH

Tue May 22 00:00:00 EDT 2018

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.

Cell reports

Shentu YP,Huo Y,Feng XL,Gilbert J,Zhang Q,Liuyang ZY,Wang XL,Wang G,Zhou H,Wang XC,Wang JZ,Lu YM,Westermarck J,Man HY,Liu R

Tue Jul 17 00:00:00 EDT 2018

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.

Cell reports

Shentu YP,Huo Y,Feng XL,Gilbert J,Zhang Q,Liuyang ZY,Wang XL,Wang G,Zhou H,Wang XC,Wang JZ,Lu YM,Westermarck J,Man HY,Liu R

Tue Jul 17 00:00:00 EDT 2018

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.

Cell reports

Shentu YP,Huo Y,Feng XL,Gilbert J,Zhang Q,Liuyang ZY,Wang XL,Wang G,Zhou H,Wang XC,Wang JZ,Lu YM,Westermarck J,Man HY,Liu R

Tue Jul 17 00:00:00 EDT 2018

BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus.

Stem cell reports

Hou H,Fan Q,He W,Suh H,Hu X,Yan R

Tue Jul 11 00:00:00 EDT 2017

BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus.

Stem cell reports

Hou H,Fan Q,He W,Suh H,Hu X,Yan R

Tue Jul 11 00:00:00 EDT 2017

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Zhang Y,Yang X,Jin G,Yang X,Zhang Y

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Polysaccharides from Pleurotus ostreatus alleviate cognitive impairment in a rat model of Alzheimer's disease.

International journal of biological macromolecules

Zhang Y,Yang X,Jin G,Yang X,Zhang Y

Tue Nov 01 00:00:00 EDT 2016

Cystatin C Shifts APP Processing from Amyloid-β Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells.

PloS one

Wang XF,Liu DX,Liang Y,Xing LL,Zhao WH,Qin XX,Shang DS,Li B,Fang WG,Cao L,Zhao WD,Chen YH

Mon Jul 31 00:00:00 EDT 2017

Cystatin C Shifts APP Processing from Amyloid-β Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells.

PloS one

Wang XF,Liu DX,Liang Y,Xing LL,Zhao WH,Qin XX,Shang DS,Li B,Fang WG,Cao L,Zhao WD,Chen YH

Mon Jul 31 00:00:00 EDT 2017

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Quercetin reduces eIF2α phosphorylation by GADD34 induction.

Neurobiology of aging

Hayakawa M,Itoh M,Ohta K,Li S,Ueda M,Wang MX,Nishida E,Islam S,Suzuki C,Ohzawa K,Kobori M,Inuzuka T,Nakagawa T

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Joshi G,Chi Y,Huang Z,Wang Y

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Aβ-induced Golgi fragmentation in Alzheimer's disease enhances Aβ production.

Proceedings of the National Academy of Sciences of the United States of America

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Bioinformatics

Protein Aliases: APP beta-secretase; asp 2; ASP2; Aspartyl protease 2; BACE 1; BACE-1D; BACE-I-432; Beta secretase; Beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; Memapsin; Memapsin-2; Memapsin2; Membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2

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Gene Aliases: ASP2; BACE; BACE1; C76936; HSPC104; KIAA1149; zgc:77409

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UniProt ID: (Human) P56817, (Rat) P56819, (Mouse) P56818

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Entrez Gene ID: (Human) 23621, (Rat) 29392, (Mouse) 23821, (Zebrafish) 403005

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Function(s)

beta-amyloid binding aspartic-type endopeptidase activity protein binding peptidase activity beta-aspartyl-peptidase activity enzyme binding endopeptidase activity hydrolase activity protease

Process(es)

proteolysis membrane protein ectodomain proteolysis protein catabolic process cellular protein metabolic process beta-amyloid metabolic process myelination in peripheral nervous system positive regulation of myelination

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BACE1 Polyclonal Antibody

BACE1 Antibody (12807-1-AP) in IHC (P)

Product Details

12807-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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